Approved studies using CPRD Data

Access to CPRD data, including UK Primary Care Data, and linked data such as Hospital Episode Statistics, is subject to protocol approval via CPRD’s Research Data Governance (RDG) Process. Independent scientific and patient advice is provided by Expert Review Committees (ERCs) and the Central Advisory Committee (CAC). 

A summary of all approved protocols, including a lay and technical summary of the proposed research, is published three months after RDG approval. COVID-19 research protocols are being fast-tracked and all approved summaries are published within 72 hours to ensure transparency and to help avoid unnecessary duplication. 

Protocols below are listed in order of date of approval. Please click on the study title for more details. 

Peer-reviewed publications from research using CPRD data will be listed on our bibliography page

Approved studies using CPRD Data

Date of Approval Sort descending Title
Association between glycated hemoglobin (HbA1c), weight and hypoglycemia to treatment choice and medication adherence in Type 2 Diabetes Mellitus (T2DM)
Incidence of liver failure and non-viral hepatitis in Multiple Sclerosis (MS) patients and in the general population - a study using the CPRD
Estimating heterogeneous treatment effects from routinely collected health data: A case study on anticoagulant therapy for atrial fibrillation patients.
The impact of polypharmacy on health outcomes in older patients: a retrospective cohort study using CPRD database.
An epidemiological study of Antiphospholipid Syndrome using electronic health records
Disease burden of diabetes patients with high dose insulin treatment in CPRD
Urinary tract infections in the elderly - care pathways and characteristics
Comparative effectiveness of lansoprazole and omeprazole for the prevention of gastrointestinal bleeding and malignancy
Primary Care and Access To Surgical Treatment For Women With Urinary Incontinence
The relationship between non-valvular atrial fibrillation and dementia
Association between diabetes control and risk of fractures: a follow-up and a nested case control
Quantifying variation in UK primary care test use: A 15 year retrospective CPRD analysis of temporal and geographical variation in test use.
Healthcare Resource Utilization and Costs among Patients with and without Infection after Intramedullary Nailing for A Tibial Shaft Fracture
Temporal Trend of Severe Hypoglycaemia and Diabetic Ketoacidosis and the Relationship Between HbA1c or HbA1c variability and Risk of Severe Hypoglycaemia and Diabetic Ketoacidosis
Morbidity among HIV-positive people in England: a cross-sectional, population-based CALIBER study
Proton pump inhibitor use and risk of developing Alzheimer's disease or vascular dementia
Incidence, prevalence, mortality and health-service use among people with systemic sclerosis (scleroderma) in the UK Clinical Practice Research Datalink
The incidence and mortality of complicated diverticular disease and associated outcomes following intervention
Ocular morbidity associated with Giant Cell Arteritis and Polymyalgia Rheumatica: a controlled cohort study using the UK Clinical Practice Research Datalink
Investigating the possible role of BLood eosinophil counts in guiding ANti-inflammatory treatment of COPD exAcerbations (BLANCA)