Approved studies using CPRD Data

Access to CPRD data, including UK Primary Care Data, and linked data such as Hospital Episode Statistics, is subject to protocol approval via CPRD’s Research Data Governance (RDG) Process. Independent scientific and patient advice is provided by Expert Review Committees (ERCs) and the Central Advisory Committee (CAC). 

A summary of all approved protocols, including a lay and technical summary of the proposed research, is published three months after RDG approval. COVID-19 research protocols are being fast-tracked and all approved summaries are published within 72 hours to ensure transparency and to help avoid unnecessary duplication. 

Protocols below are listed in order of date of approval. Please click on the study title for more details. 

Peer-reviewed publications from research using CPRD data will be listed on our bibliography page

Approved studies using CPRD Data

Date of Approval Sort descending Title
Sulphonylurea treatment and risk of myocardial infarction and all-cause mortality: a population-based cohort study
Nitrates, 5-alpha-reductase inhibitors and hormone replacement therapy and the risk of gastrointestinal cancers.
Loop diuretic use and risk of adverse outcomes among patients with atrial fibrillation
The effect of smoking on post-operative complications following hip or knee joint replacement
Characterising the natural history and risk factors for the development of psoriatic arthritis in a UK population
Statin use and incident Achilles or biceps tendon rupture
The utilization and toxicity profile of oral corticosteroids among asthma patients in the UK: an epidemiological study using Data from the Clinical Practice Research Datalink (CPRD).
GLP-1 agonists and the risk of breast cancer in patients with type 2 diabetes
How do we better understand the current management of patients with Chronic Rhinosinusitis within the National Health Service?
The diagnostic utility of inflammatory markers in primary care: a prospective cohort study.
Chief Medical Officer Annual Report
Risk of MI associated with acute exacerbations of chronic obstructive pulmonary disease (COPD): a self-controlled case series
Risk of hypoglycaemia in users of sulphonylureas with renal impairment: a population-based cohort study
Risks and benefits of bisphosphonate use in patients with chronic kidney disease: a population-based cohort study
Burden of medically attended acute gastroenteritis and aetiology: a cohort study in CPRD in England.
The role of social determinants in vaccine uptake and burden of vaccine preventable diseases
Annual Healthcare Resource Use and Costs for Eczema in Children: A Cost of Illness Study for the English NHS
Potential benefits of antithrombotic treatment in reducing risk of subsequent cardiovascular events among patients with a prior myocardial infarction in England
A study on the epidemiology of treated glaucoma in the United Kingdom
Risk of fragility fracture across inflammatory conditions: a UK population study