Approved studies using CPRD Data

Access to CPRD data, including UK Primary Care Data, and linked data such as Hospital Episode Statistics, is subject to protocol approval via CPRD’s Research Data Governance (RDG) Process. Independent scientific and patient advice is provided by Expert Review Committees (ERCs) and the Central Advisory Committee (CAC). 

A summary of all approved protocols, including a lay and technical summary of the proposed research, is published three months after RDG approval. COVID-19 research protocols are being fast-tracked and all approved summaries are published within 72 hours to ensure transparency and to help avoid unnecessary duplication. 

Protocols below are listed in order of date of approval. Please click on the study title for more details. 

Peer-reviewed publications from research using CPRD data will be listed on our bibliography page

Approved studies using CPRD Data

Date of Approval Sort descending Title
Estimating the prevalence of myasthenia gravis and neuromyelitis optica through the Clinical Practice Research Datalink
Trends and factors associated with therapy decisions in newly diagnosed COPD patients in GOLD groups A and B.
A non-interventional study using the Clinical Practice Research Datalink (CPRD) database
Risk factors for influenza-related complications in children
The association between bariatric surgery and renal outcomes
Estimation of undiagnosed lysosomal acid lipase deficiency in a paediatric population: a UK database study
A nested case-controlled study of the association between incident pneumonia, dysphagia and the formulation of commonly prescribed medication among people with dementia.
Assessing the risk of infection among babies born to mothers with Systemic Lupus Erythematosus; a study of the first two years of life.
Primary and secondary healthcare contacts in children born preterm and their households
Determining the annual proportion of women who could receive an opportunistic assessment of familial breast cancer in primary care to inform an economic model
Zoster vaccine effectiveness against incident herpes zoster and post-herpetic neuralgia in elderly in England
Descriptive study of patients with haemophilia in the CPRD.
Historical cohort study to evaluate undertreatment and disease outcomes for patients with coexisting Heart Failure and Chronic Obstructive Pulmonary Disease
Characterising the safety profile of lurasidone in clinical practice: A drug utilisation and safety study using a United Kingdom primary care database.
The characteristics and treatment patterns of Parkinson's disease patients in the UK
Assessment of Metformin Use Pattern in UK using CPRD
Low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, triglyceride and diverse non-cardiovascular diseases: a large population-based cohort study using CALIBER dataset
Androgen Deprivation Therapy for Prostate Cancer and the Risk of Hospitalisation for Community-Acquired Pneumonia
Domperidone for insufficient lactation: a drug utilization study with interrupted time-series analysis
Pharmacological Heart Failure Treatment in a Population-Based Cohort using Linked Electronic Health Records
The use and protective effect of antibiotics against complications of infection in patients in primary care: a cohort study using linked data from CPRD, HES, and ONS