Approved studies using CPRD Data

Access to CPRD data, including UK Primary Care Data, and linked data such as Hospital Episode Statistics, is subject to protocol approval via CPRD’s Research Data Governance (RDG) Process. Independent scientific and patient advice is provided by Expert Review Committees (ERCs) and the Central Advisory Committee (CAC). 

A summary of all approved protocols, including a lay and technical summary of the proposed research, is published three months after RDG approval. COVID-19 research protocols are being fast-tracked and all approved summaries are published within 72 hours to ensure transparency and to help avoid unnecessary duplication. 

Protocols below are listed in order of date of approval. Please click on the study title for more details. 

Peer-reviewed publications from research using CPRD data will be listed on our bibliography page. 

Date of Approval	Title
06/07/2016	Sequelae of gastrointestinal infections: incidence, risk factors, and economic impact on primary and secondary care settings.
06/07/2016	Stability of blood eosinophils in COPD and controls and the impact of eosinophil count, age, gender and smoking status
06/07/2016	Towards An Understanding Of Persistence, Switching, And Adherence With Medications For Over-Active Bladder:A Retrospective Observational Study In UK Clinical Practice
07/07/2016	Profiling the natural history of Crigler-Najjar syndrome using the Clinical Practice Research Datalink
11/07/2016	Cancer and risk of herpes zoster - case-control study in the Clinical Practice Research Datalink
11/07/2016	Age- and lifestyle-related chronic disease and causes of mortality among adults with cerebral palsy in the United Kingdom.
12/07/2016	Linaclotide Utilisation Study in the UK - Extended Feasibility Counts
14/07/2016	Incidence and risk factors for paediatric acute kidney injury in the UK
19/07/2016	Unsupervised clustering and topological analysis of Type-2 Diabetes and prediabetes patients in CALIBER using clinical data from electronic medical records
20/07/2016	Longitudinal Analyses of Body Mass Index and Risk of Parkinson's Disease in CPRD
20/07/2016	Estimation of undiagnosed lysosomal acid lipase deficiency in a paediatric population: a UK database study
20/07/2016	Risk of major bleeds associated with the use of direct oral anticoagulants in venous thromboembolism
20/07/2016	Use of Nalmefene (Selincro) in the UK: Cohort design using longitudinal electronic medical records (EMR)
20/07/2016	Characteristics of patients initiating empagliflozin or other non-insulin glucose lowering drugs in the United Kingdom
25/07/2016	Proton pump inhibitor use and risk of developing Alzheimer's disease or vascular dementia
28/07/2016	Safety and associated costs of glucocorticoid therapy for the treatment of chronic inflammatory diseases
28/07/2016	Androgen Deprivation Therapy for Prostate Cancer and the Risk of Hospitalisation for Community-Acquired Pneumonia
28/07/2016	An analytical framework for increasing the efficiency and validity of research using primary care databases
28/07/2016	Association between cardiovascular disease and zoster risk - case-control study in the Clinical Practice Research Datalink
29/07/2016	Trimethoprim and sudden death in patients over 65 years with urinary tract infection