Approved studies using CPRD Data

Access to CPRD data, including UK Primary Care Data, and linked data such as Hospital Episode Statistics, is subject to protocol approval via CPRD’s Research Data Governance (RDG) Process. Independent scientific and patient advice is provided by Expert Review Committees (ERCs) and the Central Advisory Committee (CAC). 

A summary of all approved protocols, including a lay and technical summary of the proposed research, is published three months after RDG approval. COVID-19 research protocols are being fast-tracked and all approved summaries are published within 72 hours to ensure transparency and to help avoid unnecessary duplication. 

Protocols below are listed in order of date of approval. Please click on the study title for more details. 

Peer-reviewed publications from research using CPRD data will be listed on our bibliography page. 

Date of Approval	Title
29/10/2016	Investigating safety of 'metabolically healthy obesity' and sustainability from community and tertiary based databases in the UK
03/11/2016	Metformin and the incidence of lymphoid malignancies in patients with type 2 diabetes
07/11/2016	Is Hydroxychloroquine associated with decreased mortality among people with Rheumatoid Arthritis
07/11/2016	Blood eosinophil count and prospective asthma disease burden
07/11/2016	20 year trends for prevalence and incidence of Resistant Hypertension in the United Kingdom and prognosis in adults with hypertension
08/11/2016	Gender differences in Chronic Obstructive Pulmonary Disease: baseline characteristics, progression, and exacerbations in the United Kingdom's Clinical Practice Research Datalink
09/11/2016	Diagnosis and treatment of dementia in primary care in the UK
10/11/2016	Benefits of high dose ICS in patients with asthma and high blood eosinophil counts
14/11/2016	Investigating the cost effectiveness of alternative oral antiplatelet regimens in patients with type 2 diabetes in England.
14/11/2016	Effect of statin therapy in older patients after a first cerebrovascular event or myocardial infarction, a population based cohort study in the CPRD
16/11/2016	Impact of affluence, atopy and childhood infections on Hodgkin’s Lymphoma incidence in the UK
23/11/2016	An interrupted time series analysis investigating the impact of regulatory advice on nitrofurantoin prescribing in UK primary care.
24/11/2016	Aromatase Inhibitors and Risk of Colorectal Cancer in Post-menopausal women with breast cancer
24/11/2016	The association between patterns of glucocorticoid therapy and risk of developing cataracts and glaucoma in adults.
24/11/2016	Therapy decisions in newly diagnosed COPD patients in GOLD groups A and B- follow up of patients receiving different therapies. A non-interventional study using the Clinical Practice Research Datalink (CPRD) database.
24/11/2016	A study estimating the occurrence of lower back pain annually in the UK
30/11/2016	Measuring the potential adverse impact of the adoption of prescribing guidelines in primary care
01/12/2016	Identification of patients with post-stroke focal spasticity of the upper or lower limb who were treated with botulinum toxin A, and health-economic evaluation of treatment with botulinum toxin A: a cohort study in England
08/12/2016	What is the incidence of Developmental Dysplasia of the Hip requiring intervention, and what proportion are diagnosed after six months of age?
08/12/2016	Assessment of the Risk of Hypertension and Cardiovascular Disease In Women with a History of Pregnancy Complications.