Approved studies using CPRD Data

Access to CPRD data, including UK Primary Care Data, and linked data such as Hospital Episode Statistics, is subject to protocol approval via CPRD’s Research Data Governance (RDG) Process. Independent scientific and patient advice is provided by Expert Review Committees (ERCs) and the Central Advisory Committee (CAC). 

A summary of all approved protocols, including a lay and technical summary of the proposed research, is published three months after RDG approval. COVID-19 research protocols are being fast-tracked and all approved summaries are published within 72 hours to ensure transparency and to help avoid unnecessary duplication. 

Protocols below are listed in order of date of approval. Please click on the study title for more details. 

Peer-reviewed publications from research using CPRD data will be listed on our bibliography page. 

Date of Approval	Title
08/12/2016	Equitable access to smoking cessation therapies for older smokers
08/12/2016	Alternative methods to account for patients with a prior history of treatment in comparative effectiveness studies: an illustration with insulin glargine and breast cancer
08/12/2016	Assessment of the Risk of Hypertension and Cardiovascular Disease In Women with a History of Pregnancy Complications.
08/12/2016	A comparison of the EMPA-REG OUTCOME clinical trial population with T2DM patients treated in the routine clinical practice: An exploratory study using the Clinical Practice Research Datalink (CPRD).
08/12/2016	What is the incidence of Developmental Dysplasia of the Hip requiring intervention, and what proportion are diagnosed after six months of age?
08/12/2016	Diabetes, glycaemic control and risk of infectious disease: cohort and case-crossover studies in primary care
08/12/2016	Association of Polycystic Ovary Syndrome with patient and offspring mental health outcomes: a retrospective, observational study
08/12/2016	Ethnicity, Cardiovascular Disease and the Risk of dementia
08/12/2016	Understanding the diagnostic pathway for brain tumours in adults and its potential impact on clinical care and outcomes
08/12/2016	Patterns of LDL-C lowering by Statins and their association with Cardiovascular Outcomes in the General Population
08/12/2016	Development and validation of risk prediction equations and the burden of Hyperkalemia: a retrospective cohort study using routinely collected clinical practice data
08/12/2016	Pericarditis diagnosis in the CPRD: a potential early indicator of undetected cancer and marker of subsequent increased cancer risk
08/12/2016	Burden of Hyperkalemia among individuals seeking health care services in England
09/12/2016	The association between body mass index and acute kidney injury at start and during hospitalisation
09/12/2016	Using Big data Research to tackle antIbiotic resisTance (BRIT)
12/12/2016	The risk of hypomagnesemia and electrolyte disturbances associated with the use of long-term proton pump Inhibitor: a population-based cohort study.
16/12/2016	Post-authorization Safety Study: Evaluation of Neoplasm Events in Users of Mirabegron and Other Treatments for Overactive Bladder in the CPRD
20/12/2016	Assessing the association between incretin-based drugs and the incidence of colon cancer in patients with type 2 diabetes
20/12/2016	A data-driven approach for identifying falls subgroups through semantic similarity analysis
21/12/2016	Cohort study assessing the association between hormone therapy use in female breast cancer survivors and subsequent risk of cardiovascular diseases in the UK