Approved studies using CPRD Data

Access to CPRD data, including UK Primary Care Data, and linked data such as Hospital Episode Statistics, is subject to protocol approval via CPRD’s Research Data Governance (RDG) Process. Independent scientific and patient advice is provided by Expert Review Committees (ERCs) and the Central Advisory Committee (CAC). 

A summary of all approved protocols, including a lay and technical summary of the proposed research, is published three months after RDG approval. COVID-19 research protocols are being fast-tracked and all approved summaries are published within 72 hours to ensure transparency and to help avoid unnecessary duplication. 

Protocols below are listed in order of date of approval. Please click on the study title for more details. 

Peer-reviewed publications from research using CPRD data will be listed on our bibliography page. 

Date of Approval	Title
14/02/2017	Potentially inappropriate prescribing in people with dementia in England: a prospective cohort study.
14/02/2017	Evaluation of the risk of intracranial and gastrointestinal bleeding events in patients concurrently prescribed non-steroidal anti-inflammatory drugs and SSRI antidepressants.
14/02/2017	Non-specific effects of vaccination in England
14/02/2017	Trajectories of metabolic and clinical parameters prior to the onset of dementia in people with Type 2 diabetes
17/02/2017	Use of hormone replacement therapy and risk of venous thromboembolism
17/02/2017	An evaluation of the prevalence, epidemiology and burden of illness of hypophosphatasia (HPP) in the United Kingdom.
20/02/2017	A study on the epidemiology of treated glaucoma in the United Kingdom
22/02/2017	Changes over time in the monitoring of cardiovascular risk in primary care, and the use of statins for the primary and secondary prevention of cardiovascular disease.
01/03/2017	Drug utilisation study of new users of umeclidinium / vilanterol (UMEC/VI) and umeclidinium (UMEC) in the primary care setting
01/03/2017	Domestic violence and abuse and prescription of emergency contraception: a nested case-control study in CPRD
01/03/2017	Burden of disease in patients with COPD and high blood eosinophil counts
05/03/2017	Stratified 30 day excess risks of emergency hospital admissions and death following gastrointestinal endoscopy
06/03/2017	Canagliflozin in patients with type 2 diabetes: understanding the real world evidence: CAPTURE study 'Capture - treatment patterns in EMEA'
08/03/2017	Pattern of use of Direct Oral AntiCoagulant (DOAC) in Non-Valvular Atrial Fibrillation (NVAF) patients in UK general practices
08/03/2017	Exploration of long term cardiovascular outcomes following pregnancy complicated by hypertensive disorders or pregnancy
08/03/2017	Statin prescribing and depression after incident stroke
10/03/2017	The risk of fractures in new users of statins: A propensity-score matched sequential cohort study
10/03/2017	Matched population-based cohort study determining the incidence and risk of cardiovascular outcomes for patients with familial hypercholesterolaemia
12/03/2017	Accounting for multimorbidity, competing risk and direct treatment disutility in risk prediction tools for the primary prevention of cardiovascular disease and fracture.
13/03/2017	The diagnostic utility of inflammatory markers in primary care: a prospective cohort study.