Approved studies using CPRD Data

Access to CPRD data, including UK Primary Care Data, and linked data such as Hospital Episode Statistics, is subject to protocol approval via CPRD’s Research Data Governance (RDG) Process. Independent scientific and patient advice is provided by Expert Review Committees (ERCs) and the Central Advisory Committee (CAC). 

A summary of all approved protocols, including a lay and technical summary of the proposed research, is published three months after RDG approval. COVID-19 research protocols are being fast-tracked and all approved summaries are published within 72 hours to ensure transparency and to help avoid unnecessary duplication. 

Protocols below are listed in order of date of approval. Please click on the study title for more details. 

Peer-reviewed publications from research using CPRD data will be listed on our bibliography page. 

Date of Approval	Title
12/10/2015	The efficacy and safety of concomitant treatment with telmisartan, candesartan or bisoprolol in combination with amlodipine in patients with essential arterial hypertension: outcomes in real world practice
12/10/2015	Estimating the healthcare use and costs of children born to pregnant smokers
14/10/2015	A study of multifactorial intervention in type 2 diabetes and chronic kidney disease
14/10/2015	The association between lansoprazole and tuberculosis disease; a primary care based cohort study
19/10/2015	Usage Patterns of Selected Systemic NSAIDs (Including Diclofenac): A Retrospective Cohort Study
27/10/2015	Determinants of Zoster vaccination acceptance in people eligible for NHS shingles vaccination programme
27/10/2015	Morbidity among HIV-positive people in England: a cross-sectional, population-based CALIBER study
27/10/2015	Prediagnostic presentations and comorbidities of multiple sclerosis in primary care: a case-control study
28/10/2015	Disease burden of diabetes patients with high dose insulin treatment in CPRD
29/10/2015	Predicting individual risk of future hip and knee replacement for osteoarthritis
04/11/2015	Stress Urinary Incontinence and Suicidality Seen in the Clinical Practice Research Datalink (CPRD)
04/11/2015	Descriptive Characteristics of the Clinical Practice Research Datalink (CPRD) EMIS database.
05/11/2015	Evaluation of Potential Cardiovascular, Respiratory and Metabolic Effects of Long-term Use of Proton-Pump Inhibitor Therapy in Older Patients
16/11/2015	Is gout a risk factor for erectile dysfunction?
17/11/2015	The prescribing of codeine for the treatment of pain in children: A descriptive study
17/11/2015	The role of systemic inflammatory diseases in long-term morbidity and mortality: a retrospective, matched-cohort study in the Clinical Practice Research Datalink
19/11/2015	Using pharmacoepidemiology to test medications associated with altered breast cancer risk identified from connectivity mapping
19/11/2015	Effects of selective serotonin reuptake inhibitors on the risk of mortality in patients with epilepsy: a CALIBER study using linked data
20/11/2015	Risk of MI associated with acute exacerbations of chronic obstructive pulmonary disease (COPD): a self-controlled case series
24/11/2015	Utilization of Standard and Target-Specific Oral Anticoagulants among Adults in the United Kingdom with Incident Non-Valvular Atrial Fibrillation