Approved studies using CPRD Data

Access to CPRD data, including UK Primary Care Data, and linked data such as Hospital Episode Statistics, is subject to protocol approval via CPRD’s Research Data Governance (RDG) Process. Independent scientific and patient advice is provided by Expert Review Committees (ERCs) and the Central Advisory Committee (CAC). 

A summary of all approved protocols, including a lay and technical summary of the proposed research, is published three months after RDG approval. COVID-19 research protocols are being fast-tracked and all approved summaries are published within 72 hours to ensure transparency and to help avoid unnecessary duplication. 

Protocols below are listed in order of date of approval. Please click on the study title for more details. 

Peer-reviewed publications from research using CPRD data will be listed on our bibliography page

Approved studies using CPRD Data

Date of Approval Sort descending Title
The effect of metformin on patient outcome after acute myocardial infarction
Incidence and Prevalence of the Parkinson's Disease in the United Kingdom during 1987-2014
Use of novel regression discontinuity design to investigate safety of statins in the UK Clinical Practice Research Datalink
Descriptive assessment of the Hospital Treatment Insights database and its link to the Clinical Practice Research Datalink for research on antibiotic dispensing in English hospitals
Association between cardiovascular disease and zoster risk - case-control study in the Clinical Practice Research Datalink
Renal Outcomes with DPP-4 Inhibitors Compared with Sulfonylurea as Add-on to Metformin among Patients with Type 2 Diabetes Mellitus in the UK
The role of the microbiome in joint and bone disease
Potential benefits of antithrombotic treatment in reducing risk of subsequent cardiovascular events among patients with a prior myocardial infarction in England
A study on the epidemiology of treated glaucoma in the United Kingdom
Evidence for and implications of channeling in the use of nonprescription acetaminophen and ibuprofen in an electronic medical records database
Validity of UK general practice prescribing safety indicators in predicting adverse events
Psychological stress and risk of herpes zoster
The epidemiology and treatment patterns of patients with Gastro-oesophageal reflux disease (GORD) in routine general practice.
Oral anticoagulants for atrial fibrillation and the risk of fractures
Investigating safety of 'metabolically healthy obesity' and sustainability from community and tertiary based databases in the UK
Body mass index and cause-specific mortality - population-based cohort study using record linkage
Evaluation of the risk of intracranial and gastrointestinal bleeding events in patients concurrently prescribed non-steroidal anti-inflammatory drugs and SSRI antidepressants.
The Effects of Adherence and Treatment Intensity on Cardiovascular Outcomes in Patients with Atherosclerosis or Other Cardiovascular Risk Factors Treated with Statins and/or Ezetimibe: A Cohort Study in the United Kingdom
Predicting atrial fibrillation or atrial flutter (AF/F) using electronic patient health records in the United Kingdom
Prescribing patterns of dependence forming medicines: Benzodiazepines, z-drugs, opioids and GABAergic drugs