Approved studies using CPRD Data

Access to CPRD data, including UK Primary Care Data, and linked data such as Hospital Episode Statistics, is subject to protocol approval via CPRD’s Research Data Governance (RDG) Process. Independent scientific and patient advice is provided by Expert Review Committees (ERCs) and the Central Advisory Committee (CAC). 

A summary of all approved protocols, including a lay and technical summary of the proposed research, is published three months after RDG approval. COVID-19 research protocols are being fast-tracked and all approved summaries are published within 72 hours to ensure transparency and to help avoid unnecessary duplication. 

Protocols below are listed in order of date of approval. Please click on the study title for more details. 

Peer-reviewed publications from research using CPRD data will be listed on our bibliography page

Approved studies using CPRD Data

Date of Approval Sort descending Title
Effects of selective serotonin reuptake inhibitors on the risk of mortality in patients with epilepsy: a CALIBER study using linked data
Incidence and risk factors for paediatric acute kidney injury in the UK
Longitudinal Analyses of Body Mass Index and Risk of Parkinson's Disease in CPRD
Trends in the prescription of oral anticoagulants in UK primary care (2009-2015)
Exploring prescribing patterns, treatment trajectory and healthcare resources use of breast cancer patients in primary care to inform community pharmacy services for breast cancer survivors in England
Developing a co-morbidity tool to predict mortality for linked primary and secondary care data.
Utilization and Adverse Outcomes of Ondansetron and Fluconazole Therapy during Pregnancy
Systemic sclerosis in the UK: what is the disease burden and are there associations with other serious health outcomes?
Lifestyle and socio-economic risk factors for non-valvular atrial fibrillation
Assessing channelling bias and effectiveness in newly marketed glucose-lowering medications - a retrospective cohort study
Resource use associated with Idiopathic Pulmonary Fibrosis
A descriptive study of LAIV utilization to identify and characterize medication errors due to expired vaccine use in individuals 2-17 years of age in the CPRD
The Burden of Skin Cancer in UK Primary Care 2004-2014: a Time-Trend Analysis from the Clinical Practice Research Datalink.
Extreme restriction design as a method for removing confounding by indication in pharmacoepidemiologic research
Association of urinary tract infections with antipsychotic drug use in older patients
Changes over time in the monitoring of cardiovascular risk in primary care, and the use of statins for the primary and secondary prevention of cardiovascular disease.
Ovulation-Inducing Fertility Treatments and the Long-Term Risk of Breast Cancer
Can CHA2DS2-VASc score be used to identify patients under 65 years old at high risk of atrial fibrillation?
Impact of the definition of osteoarthritis and the timing of its onset on the association between type 2 diabetes mellitus and osteoarthritis: Clinical Practice Research Datalink.
Serum creatinine elevation following renin-angiotensin-aldosterone system blockade, adherence to monitoring and discontinuation guidelines, and long-term cardiorenal risks