Approved studies using CPRD Data

Access to CPRD data, including UK Primary Care Data, and linked data such as Hospital Episode Statistics, is subject to protocol approval via CPRD’s Research Data Governance (RDG) Process. Independent scientific and patient advice is provided by Expert Review Committees (ERCs) and the Central Advisory Committee (CAC). 

A summary of all approved protocols, including a lay and technical summary of the proposed research, is published three months after RDG approval. COVID-19 research protocols are being fast-tracked and all approved summaries are published within 72 hours to ensure transparency and to help avoid unnecessary duplication. 

Protocols below are listed in order of date of approval. Please click on the study title for more details. 

Peer-reviewed publications from research using CPRD data will be listed on our bibliography page. 

Date of Approval	Title
16/02/2018	Comparative effectiveness of initial bronchodilator therapies in COPD
19/02/2018	Characteristics of patients initiating and switching oral anticoagulants (OACs) for non-valvular atrial fibrillation (NVAF) in the UK general practices
19/02/2018	Distribution of COPD patients by COPD GOLD Classification and their primary health-care and respiratory medication utilization in the Clinical Practice Research Datalink (CPRD)
22/02/2018	Epidemiology of pre-diagnosed rheumatoid arthritis and early classification of high severity at diagnosis
22/02/2018	Identification of patterns of symptoms and comorbidities presented to primary care prior to diagnosis of first episode psychosis: an electronic health record study
23/02/2018	Real-World Evidence in Oncology in England: Treatment patterns and Healthcare Resource Utilization
23/02/2018	Real-World Evidence in Oncology in England: Epidemiology, Patient Characteristics and Survival
28/02/2018	Causes of mortality in patients with comorbid COPD and heart failure in the United Kingdom, 2005-2017
28/02/2018	Developing tools for preventing delirium in primary care
28/02/2018	Longitudinal trends in continuity of care in English general practice
01/03/2018	COMIX – Comorbidity index for predicting mortality in clinical studies as well as comparing its performance to existing comorbidity indices.
05/03/2018	Prescribing trends of gabapentinoids in UK primary care
05/03/2018	Identifying coincident drugs that alter headache progression and remission.
06/03/2018	Evaluation of the patterns of presentation and treatment of cough in order to understand the prevalence and epidemiology of chronic cough: a preliminary investigation
06/03/2018	Is smoking a risk factor for autoimmune hepatitis? An English registry-based case-control study using data from the Clinical Practice Research Datalink and linked Hospital Episode Statistics
08/03/2018	Comparisons of Staphylococcus aureus infection and other outcomes between users of angiotensin-converting-enzyme inhibitors and angiotensin II receptor blockers: lessons for COVID-19 from a nationwide cohort study
08/03/2018	Statin use in chronic obstructive pulmonary disease (COPD) patients and risk of exacerbations: a propensity score matched cohort study
08/03/2018	An observational retrospective cohort analysis in adults with systemic lupus erythematosus/lupus nephritis to describe the characteristics of disease severity, disease activity (flare frequency), treatment, costs, and outcomes
08/03/2018	Blood eosinophil and creatine reactive protein as biomarkers of response to inhaled corticosteroids in COPD
09/03/2018	Evaluating and enhancing the primary care medicines review in patients with complex health needs