Approved studies using CPRD Data

Access to CPRD data, including UK Primary Care Data, and linked data such as Hospital Episode Statistics, is subject to protocol approval via CPRD’s Research Data Governance (RDG) Process. Independent scientific and patient advice is provided by Expert Review Committees (ERCs) and the Central Advisory Committee (CAC). 

A summary of all approved protocols, including a lay and technical summary of the proposed research, is published three months after RDG approval. COVID-19 research protocols are being fast-tracked and all approved summaries are published within 72 hours to ensure transparency and to help avoid unnecessary duplication. 

Protocols below are listed in order of date of approval. Please click on the study title for more details. 

Peer-reviewed publications from research using CPRD data will be listed on our bibliography page. 

Date of Approval	Title
13/03/2018	Cholesterol lowering medications and risk of fatty liver disease and liver cancer
13/03/2018	Rheumatological conditions as risk factors for self-harm. A retrospective cohort study
13/03/2018	Reproducible Evidence: Practices to Enhance and Achieve Transparency (REPEAT): Replication of "Identification of impaired fasting glucose, healthcare utilization and progression to diabetes in the UK using the Clinical Practice Research Datalink (CPRD)".
13/03/2018	Prevalence of current asthma in the UK and changes over time with treatment
13/03/2018	Predictive value of cancer for dementia in cohorts with and without T2DM: a national observational study
13/03/2018	Utilization and Adverse Outcomes of Ondansetron and Fluconazole Therapy during Pregnancy
13/03/2018	Safety of reducing AB prescribing in primary care. Systematic new evidence from electronic health records
13/03/2018	Distal Renal Tubular Acidosis and Cystinuria in Adult and Paediatric populations: epidemiology, patient pathways and costs in the U.K
14/03/2018	Evaluating and Discovering Indicators of Care from Observational Data: A Case Study on Atrial Fibrillation
14/03/2018	5-alpha reductase inhibitors for benign prostate hyperplasia and the risk of urological cancers and other non-cancer adverse events
19/03/2018	Migraine in the UK: A descriptive cohort study of the burden of disease and health care resource utilisation
19/03/2018	Risk factor trends and aetiological mechanisms leading to Heart Failure (HF) and outcomes; a study of ethnicity, gender and deprivation in the UK general population
19/03/2018	The progression of ischaemic heart disease to heart failure in different ethnic groups; a contemporary population-based cohort study in England
20/03/2018	Dosage regimens and interrupted treatment in heart failure: a national retrospective cohort study in primary care.
20/03/2018	Identifying predictors of adherence to diabetes medications: an observational cohort study
20/03/2018	Exploring ethnicity as a risk factor for post-stroke dementia: a cohort study using the UK Clinical Practice Research Datalink
20/03/2018	Gout and Neurodegenerative Disorders: A retrospective cohort study in the Clinical Practice Research Datalink
21/03/2018	Survival of patients with heart failure in community (SurviveHF)
26/03/2018	Reproducible Evidence: Practices to Enhance and Achieve Transparency (REPEAT): Study 2 - Replication of "Drug therapy for alcohol dependence in primary care in the UK: A Clinical Practice Research Datalink study"
26/03/2018	Risks of glucocorticoid therapy in PMR and GCA patients with co-existing type 2 diabetes