Approved studies using CPRD Data

Access to CPRD data, including UK Primary Care Data, and linked data such as Hospital Episode Statistics, is subject to protocol approval via CPRD’s Research Data Governance (RDG) Process. Independent scientific and patient advice is provided by Expert Review Committees (ERCs) and the Central Advisory Committee (CAC). 

A summary of all approved protocols, including a lay and technical summary of the proposed research, is published three months after RDG approval. COVID-19 research protocols are being fast-tracked and all approved summaries are published within 72 hours to ensure transparency and to help avoid unnecessary duplication. 

Protocols below are listed in order of date of approval. Please click on the study title for more details. 

Peer-reviewed publications from research using CPRD data will be listed on our bibliography page. 

Date of Approval	Title
29/08/2018	Age at onset of multiple cardiovascular disease conditions: differences in ethnic subgroups by diabetes status
04/09/2018	Association of early detection of non-diabetic hyperglycaemia and clinical outcomes in England: a retrospective cohort study
10/09/2018	Cardiovascular risk and kidney disease progression in chronic kidney disease
10/09/2018	Characterization of acute coronary syndrome patients that switch from dual antiplatelet therapy to monotherapy with clopidogrel or aspirin
10/09/2018	Referral rates of severe asthma patients to asthma specialists in the UK and the impact on healthcare use
10/09/2018	Sodium-glucose co-transporter 2 inhibitors and the risk of fractures in patients with type 2 diabetes
10/09/2018	Initiation of Combination Therapy in Type 2 Diabetes Patients with high HbA1c at diagnosis
10/09/2018	Mortality trends in people with and without type 2 diabetes in UK: a CPRD observational study
11/09/2018	Uptake of pneumococcal and zoster vaccines by clinical risk groups in England
11/09/2018	Difference in Response to Inhaled Corticosteroids between smoking and non-smoking asthma patients.
12/09/2018	Feasibility study to assess the availability of appropriate records to support a retrospective, comparative, non-interventional cohort study to investigate the risk of drug induced liver injury associated with ulipristal acetate
19/09/2018	Impact of EU label changes for systemic diclofenac & hydroxyzine products: post-referral prescribing trends
19/09/2018	Infants’ and Children’s Primary and Secondary Health Care Costs associated with mode of Childbirth and Gestational Age at Birth
20/09/2018	Autoimmune blistering diseases: Incidence, prevalence, co-morbidity and prescription patterns
20/09/2018	The resource use, financial costs and related epidemiology of treating people with HIV and its associated comorbidities vs. matched controls in the UK general population
20/09/2018	An investigation of the adverse outcomes and resource use associated with anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) and their relationship with glucocorticoid (GC) treatment
21/09/2018	Reproducible Evidence: Practices to Enhance and Achieve Transparency (REPEAT): Study 7 - Replication of "Antibiotic treatment failure in four common infections in UK primary care 1991-2012: longitudinal analysis"
24/09/2018	Identifying patients with familial hypercholesterolemia who could benefit from treatment with proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors: Development and validation of a logistic regression predictive model
28/09/2018	Towards an accessible methodology in precision medicine: methods for time-to-event data and non-regular inferences with an application to treatment of type 2 diabetes
28/09/2018	The Natural History and heterogeneity in progression of Dementia in the United Kingdom