Approved studies using CPRD Data

Access to CPRD data, including UK Primary Care Data, and linked data such as Hospital Episode Statistics, is subject to protocol approval via CPRD’s Research Data Governance (RDG) Process. Independent scientific and patient advice is provided by Expert Review Committees (ERCs) and the Central Advisory Committee (CAC). 

A summary of all approved protocols, including a lay and technical summary of the proposed research, is published three months after RDG approval. COVID-19 research protocols are being fast-tracked and all approved summaries are published within 72 hours to ensure transparency and to help avoid unnecessary duplication. 

Protocols below are listed in order of date of approval. Please click on the study title for more details. 

Peer-reviewed publications from research using CPRD data will be listed on our bibliography page. 

Date of Approval	Title
02/01/2019	BurDeN Study: Incidence and Burden of Disease from Shingles and Post-Herpetic Neuralgia in the over 80 year olds in the UK
10/01/2019	Understanding the Relationship between Multimorbidity in Later Life, Use of Health Services and Costs of Health Care (MuSeCol)
10/01/2019	Are beta blockers beneficial or harmful in obstructive sleep apnoea?
10/01/2019	Mapping the opportunities for earlier diagnosis and characterising the management costs of psoriasis and impact of key co-morbidities
10/01/2019	Guideline discordant diagnostic care: when do primary care referrals not reflect guidelines for suspected cancer?
10/01/2019	Does aspirin affect the risk of cardiovascular events after pneumonia?
10/01/2019	The influence of the number of concomitant drugs used, on the safety and efficacy of NOACs compared to warfarin in patients with atrial fibrillation treated in routine care
10/01/2019	REPEAT: Study 21 - Replication of “Managing glycaemia in older people with type 2 diabetes: A retrospective, primary care-based cohort study, with economic assessment of patient outcomes”
14/01/2019	Epidemiology of Valvular Heart Disease in Epilepsy Patients
15/01/2019	Comparing the characteristics between non-valvular atrial fibrillation patients who are treated or untreated with oral anticoagulants
17/01/2019	Effectiveness of long acting muscarinic-antagonist- (LAMA) as an add-on to inhaled corticosteroids / long acting beta-agonists (LABA) in smoking asthmatics
17/01/2019	Identifying predictors of drug treatment response in bipolar disorder
17/01/2019	Dose adjustment or discontinuous use of direct oral anticoagulants related to the concurrent use of potential interacting drugs
17/01/2019	Recording of anxiety diagnoses and symptoms in primary care and trends in prescribing for anxiety
21/01/2019	Cardiovascular disease in homeless individuals: epidemiology, risk prediction and management
21/01/2019	The association between prescription opioids and risk of bone fracture: a self-controlled case series study using the Clinical Practice Research Datalink
21/01/2019	Comparative effectiveness of first line anti-hypertensive agents stratified by age and ethnicity
22/01/2019	Reproducible Evidence: Practices to Enhance and Achieve Transparency (REPEAT): Study 14 - Replication of “Cardiovascular risks in smokers treated with nicotine replacement therapy: a historical cohort study”
22/01/2019	Life-Limiting Conditions: the health of children and their Mothers
23/01/2019	Measurement of dementia disease progression in primary care: a cohort study