Approved studies using CPRD Data

Access to CPRD data, including UK Primary Care Data, and linked data such as Hospital Episode Statistics, is subject to protocol approval via CPRD’s Research Data Governance (RDG) Process. Independent scientific and patient advice is provided by Expert Review Committees (ERCs) and the Central Advisory Committee (CAC). 

A summary of all approved protocols, including a lay and technical summary of the proposed research, is published three months after RDG approval. COVID-19 research protocols are being fast-tracked and all approved summaries are published within 72 hours to ensure transparency and to help avoid unnecessary duplication. 

Protocols below are listed in order of date of approval. Please click on the study title for more details. 

Peer-reviewed publications from research using CPRD data will be listed on our bibliography page. 

Date of Approval	Title
14/02/2019	Comparative safety profile of antidiabetic drug regimens containing SGLT-2 inhibitors and/or GLP-1 receptor agonists among type 2 diabetes patients
21/02/2019	The impact of musculoskeletal conditions on outcome of hospital care for acute coronary syndrome and stroke: a linked electronic health record study
21/02/2019	Characterisation and natural history of non-exacerbating chronic obstructive pulmonary disease patients in a general practice-based population
21/02/2019	All-cause Mortality in Infants vaccinated in the routine childhood immunisation schedule in general practice in the United Kingdom
21/02/2019	Characteristics of patients initiating Spiriva Respimat in Asthma in the UK: a cross-sectional study based on the Clinical Practice Research Datalink
22/02/2019	Medical conditions and medications potentially associated with lung cancer in a population of never smokers in CPRD
22/02/2019	The association between fracture risk and diabetes duration, complications and regulation in diabetes mellitus
22/02/2019	Characteristics of lung cancer patients in clinical practice and potential study eligibility for clinical trials evaluating tyrosine kinase inhibitors or immune checkpoint inhibitors.
22/02/2019	Understanding the harms of antihypertensives, statins and antiplatelets for prevention of cardiovascular disease: A prognostic modelling and casual inference study
25/02/2019	Costs and clinical consequences of gastrointestinal bleeding events in patients with atrial fibrillation
25/02/2019	An investigation into the risk of suicide and self-harm amongst people with alcohol or opioid dependence and disorders
27/02/2019	Levothyroxine for the Treatment of Subclinical Hypothyroidism in Pregnancy: A Population-based Assessment
28/02/2019	Epidemiology and treatment pathways of ankylosing spondylitis: a retrospective UK database analysis
28/02/2019	Progression rates and risk factors for type 2 diabetes and cardiovascular disease in individuals diagnosed with gestational diabetes mellitus: A retrospective cohort study using CPRD
07/03/2019	A personalized approach to depression care: Discovering adaptive treatment strategies
07/03/2019	Cardiovascular disease in a general asthma population: UK population study
07/03/2019	Prevalence of prescription of blood pressure lowering drugs, statins and aspirin, and their effects on BP and cholesterol when taken alone and together
07/03/2019	Development and internal validation of prognostic scores for risk of lower limb amputation and all-cause mortality in patients at risk of developing diabetic foot problems, and in patients with diabetic foot ulcer
11/03/2019	Epidemiology of osteoarthritis and associated comorbidities: a combined case-control and cohort study
11/03/2019	Weight change following type 2 diabetes diagnosis and incidence of cardiovascular events and all-cause mortality