Approved studies using CPRD Data

Access to CPRD data, including UK Primary Care Data, and linked data such as Hospital Episode Statistics, is subject to protocol approval via CPRD’s Research Data Governance (RDG) Process. Independent scientific and patient advice is provided by Expert Review Committees (ERCs) and the Central Advisory Committee (CAC). 

A summary of all approved protocols, including a lay and technical summary of the proposed research, is published three months after RDG approval. COVID-19 research protocols are being fast-tracked and all approved summaries are published within 72 hours to ensure transparency and to help avoid unnecessary duplication. 

Protocols below are listed in order of date of approval. Please click on the study title for more details. 

Peer-reviewed publications from research using CPRD data will be listed on our bibliography page. 

Date of Approval	Title
27/10/2021	Bleeding events and adverse reactions in UK patients with non-valvular atrial fibrillation (NVAF) treated with edoxaban
27/10/2021	The impact of the use of immunotherapy and risk of type I diabetes mellitus (TIDM) and other immune related adverse events: a population-based observational cohort study
28/10/2021	MINERVA: Metadata for data discoverability and study replicability in observational studies – quantitative metadata describing the CPRD Aurum data source
29/10/2021	Investigating the applicability of regression discontinuity in electronic health record for assessing the effectiveness of prostate-specific antigen screening for the prevention of prostate cancer
01/11/2021	Intimate partner violence, parental substance misuse and the mental health of parents & children - a retrospective open birth cohort
02/11/2021	Quantification of potential undiagnosed Pulmonary Arterial Hypertension (PAH) patients among patients with chronic respiratory disorders and PAH-related cardiovascular conditions through machine learning models in the UK CPRD-HES databases
02/11/2021	Determining patients at risk of first Chronic Obstructive Pulmonary Disease (COPD) exacerbation in UK Global Initiative for Chronic Obstructive Lung Disease (GOLD) A and B Chronic Obstructive Pulmonary Disease (COPD) patients
05/11/2021	The management of gout in primary and secondary care in England and Wales: a descriptive study
09/11/2021	Impact of COVID-19 vaccination on preventing long COVID: a population-based cohort study using NHS data
09/11/2021	Incretin-based drugs and the prevention of exacerbations of chronic obstructive pulmonary disease among patients with type 2 diabetes mellitus
17/11/2021	The prevalence of Alzheimer's disease in England across deprivation groups: A Clinical Practice Research Datalink study
17/11/2021	Severe mental illness (SMI) and cancer screening inequalities: a cross section study
17/11/2021	Improving earlier diagnosis of coeliac disease of children and adults by predicting who is at higher risk of disease from their routine medical records
17/11/2021	Migraines and hypertensive disorders of pregnancy: a cohort study in in the UK Clinical Practice Research Datalink GOLD
17/11/2021	A cohort study of pre-pregnancy infections and risks of preterm birth
18/11/2021	The impact of painful musculoskeletal conditions on outcomes of community-acquired pneumonia
18/11/2021	Health Care Resource Utilization related to vascular ulcers in England
19/11/2021	Incretin-based drugs and the risk of acute liver injury among patients with type 2 diabetes mellitus
19/11/2021	Comparative effectiveness of Umeclidinium + Vilanterol versus Indacaterol + Glycopyrronium bromide assessing exacerbation frequency, costs and resource-use among patients with Chronic Obstructive Pulmonary Disease in a UK real-world primary care setting
22/11/2021	Feasibility assessment of women of childbearing potential (WOCBP) and pregnant women with influenza and prescribed medication exposures for influenza in CPRD