Approved studies using CPRD Data

Access to CPRD data, including UK Primary Care Data, and linked data such as Hospital Episode Statistics, is subject to protocol approval via CPRD’s Research Data Governance (RDG) Process. Independent scientific and patient advice is provided by Expert Review Committees (ERCs) and the Central Advisory Committee (CAC). 

A summary of all approved protocols, including a lay and technical summary of the proposed research, is published three months after RDG approval. COVID-19 research protocols are being fast-tracked and all approved summaries are published within 72 hours to ensure transparency and to help avoid unnecessary duplication. 

Protocols below are listed in order of date of approval. Please click on the study title for more details. 

Peer-reviewed publications from research using CPRD data will be listed on our bibliography page

Date of Approval Sort descending Title
06/01/2022 Presenting Complaints for Prostate Cancer in Primary Care
10/01/2022 Effectiveness of allopurinol on mortality and cardiovascular events in patients with gout
13/01/2022 A retrospective cohort study assessing biomarker measurements, cardiovascular risk scores, and cardiovascular complications in men diagnosed with prostate cancer and prescribed gonadotropin-releasing hormone agonist or antagonist treatment in England
13/01/2022 Sodium-glucose co-transporter 2 inhibitors and early bladder cancer events: An international multi-site study
13/01/2022 Risk of side-effects from long-term use of inhaled steroids in asthma
13/01/2022 Previous gestational diabetes mellitus and testing for type 2 diabetes mellitus and cardiovascular disease: variation by region and GP practice in the UK
17/01/2022 Proton pump inhibitors and the incidence of inflammatory bowel disease: a population-based cohort study
18/01/2022 Antidepressant treatment and outcomes in the context of polypharmacy in adults with comorbid depression and type 2 diabetes
20/01/2022 An exploration of primary and secondary care datasets for tReAtment Duration and survIval outcomes of liposarcoma patients in the UK using electronic medical recordS (RADIUS)
21/01/2022 Severe Sickle Cell Disease and Transfusion-dependent beta-thalassaemia: Economic and Clinical Burden of Disease in England
24/01/2022 Evaluation of the all-cause mortality and healthcare resource use associated with early versus late treatment initiation of rifaximin-alpha 550mg in hepatic encephalopathy patients.
24/01/2022 Impact of postpartum management of hypertensive disorders of pregnancy on long-term Cardio-vascular Disease in a Large UK Pregnancy Cohort of Linked Electronic Health Records
25/01/2022 Exploring the use of different definitions of acute exacerbation of chronic obstructive pulmonary disease in routinely collected electronic healthcare records and investigating how varying definitions may affect study results
25/01/2022 A retrospective cohort study assessing clinical outcomes in patients with cardiac resynchronisation therapy or implantable cardioverter defibrillators in England
27/01/2022 An observational retrospective cohort study describing clinical outcomes and utilisation of healthcare resources among persons with COVID-19 in England, stratified by infection severity and selected comorbidities
27/01/2022 Patient characteristics, treatment patterns, adverse outcomes, health care resource utilisation and costs in paediatric and adult patients with a diagnosis of eosinophilic esophagitis in England: A real-world observational retrospective cohort analysis
31/01/2022 Predicting healthcare utilisation using diagnoses in primary and secondary care: a study using linked UK primary and secondary care data
01/02/2022 Primary care recording of burden of illness and outcomes amongst patients with achondroplasia: A feasibility study
01/02/2022 Primary care models for the detection of clinically significant prostate cancer: the ProsDetect study
01/02/2022 How the predictions of algorithms used in healthcare provision change: an investigation using COVID-19 and Cardiovascular disease risk prediction case studies.