Approved studies using CPRD Data

Access to CPRD data, including UK Primary Care Data, and linked data such as Hospital Episode Statistics, is subject to protocol approval via CPRD’s Research Data Governance (RDG) Process. Independent scientific and patient advice is provided by Expert Review Committees (ERCs) and the Central Advisory Committee (CAC). 

A summary of all approved protocols, including a lay and technical summary of the proposed research, is published three months after researchers have access to the data to begin their study. COVID-19 research protocols are being fast-tracked and all approved summaries are published within 72 hours to ensure transparency and to help avoid unnecessary duplication. 

Protocols below are listed in order of date of approval. Please click on the study title for more details. 

Peer-reviewed publications from research using CPRD data will be listed on our bibliography page

Approved studies using CPRD Data

Date of Approval Sort ascending Title
23/03/2022 Healthcare Resource Utilisation and Associated Costs in Patients with COVID-19 in England: A Retrospective Cohort Study
01/02/2022 How the predictions of algorithms used in healthcare provision change: an investigation using COVID-19 and Cardiovascular disease risk prediction case studies.
27/01/2022 An observational retrospective cohort study describing clinical outcomes and utilisation of healthcare resources among persons with COVID-19 in England, stratified by infection severity and selected comorbidities
05/01/2022 Impact of the coronavirus disease (COVID-19) pandemic on incidence of tics in children and young people: a population-based cohort study
23/12/2021 A post-authorisation (post-marketing) observational study using existing secondary health data sources to evaluate the association between exposure to the AstraZeneca COVID-19 vaccine (AZD1222) and safety concerns
13/12/2021 Covid-19 vaccination in inflammatory conditions treated with immune suppressing drugs: a study of clinical effectiveness and vaccine safety using data from the Clinical Practice Research Datalink (CPRD)
07/12/2021 Association between thrombosis with thrombocytopenia syndrome (TTS) or thromboembolic events, and covid-19 vaccines
30/11/2021 The impact of COVID-19 on heart failure epidemiology and outcomes across primary care: a population-based cohort study
02/11/2021 Quantification of potential undiagnosed Pulmonary Arterial Hypertension (PAH) patients among patients with chronic respiratory disorders and PAH-related cardiovascular conditions through machine learning models in the UK CPRD-HES databases
02/11/2021 Determining patients at risk of first Chronic Obstructive Pulmonary Disease (COPD) exacerbation in UK Global Initiative for Chronic Obstructive Lung Disease (GOLD) A and B Chronic Obstructive Pulmonary Disease (COPD) patients
01/11/2021 Intimate partner violence, parental substance misuse and the mental health of parents & children - a retrospective open birth cohort
28/10/2021 Investigating the applicability of regression discontinuity in electronic health record for assessing the effectiveness of prostate-specific antigen screening for the prevention of prostate cancer
26/10/2021 The impact of the use of immunotherapy and risk of type I diabetes mellitus (TIDM) and other immune related adverse events: a population-based observational cohort study
26/10/2021 Bleeding events and adverse reactions in UK patients with non-valvular atrial fibrillation (NVAF) treated with edoxaban
25/10/2021 What biopsychosocial factors are associated with abortions in primary care in Britain? A case control study comparing women aged 13 to 54 who had abortions compared with those who did not.
25/10/2021 People living with diabetes and intermediate hyperglycaemia: risk of infections and effects of average level and variability of glycated haemoglobin (HbA1c) on this risk, in people from different ethnic groups
18/10/2021 Falling through the cracks: patterns of care for people with markedly elevated blood pressure seen in English primary care
14/10/2021 Estimated prevalence of multiple long term conditions
14/10/2021 Examining patterns and clusters of comorbidities in people with psoriasis
11/10/2021 Influenza and pneumococcal vaccination in adults with common inflammatory conditions treated with immune suppressing drugs: a study of vaccine uptake, clinical effectiveness and vaccine safety.