Approved studies using CPRD Data

Access to CPRD data, including UK Primary Care Data, and linked data such as Hospital Episode Statistics, is subject to protocol approval via CPRD’s Research Data Governance (RDG) Process. Independent scientific and patient advice is provided by Expert Review Committees (ERCs) and the Central Advisory Committee (CAC). 

A summary of all approved protocols, including a lay and technical summary of the proposed research, is published three months after RDG approval. COVID-19 research protocols are being fast-tracked and all approved summaries are published within 72 hours to ensure transparency and to help avoid unnecessary duplication. 

Protocols below are listed in order of date of approval. Please click on the study title for more details. 

Peer-reviewed publications from research using CPRD data will be listed on our bibliography page

Date of Approval Sort ascending Title
18/03/2024 The role of inequalities in asthma care and outcomes in England: a cohort study of people with asthma
01/03/2024 COVID-19 booster vaccine effectiveness in secondary prevention of major adverse cardiovascular events: an emulated target trial in observational data
06/02/2024 Effectiveness of COVID-19 vaccines on severe COVID-19 and post-acute cardiovascular events and diabetes following SARS-CoV-2 infection: A cohort study
29/01/2024 Quantifying the impact of the COVID-19 pandemic and the Kidney Failure Risk Equation on Chronic Kidney Disease care and outcomes in Primary Care
23/01/2024 Modelling kidney disease progression, cardiovascular outcomes and related healthcare costs in chronic kidney disease and assessing the use of risk modifying therapy in chronic kidney disease, diabetes and heart failure
23/01/2024 Comparing several pancreatic cancer risk scores or models regarding the diagnostic performance and availability of necessary parameters in primary care records of a cohort of patients with recently diagnosed diabetes mellitus
23/01/2024 Preventing steroid harms in people with polymyalgia rheumatica in England primary care - assessing the effect of prophylactic medications on fragility fractures and gastro-intestinal adverse events: a retrospective cohort study
19/01/2024 Incretin-based drugs and the incidence of endometrial cancer among patients with type 2 diabetes
19/01/2024 Sodium-glucose co-transporter 2 inhibitors vs dipeptidyl peptidase-4 inhibitors and the risk of ventricular arrhythmia among patients with type 2 diabetes: A population-based cohort study
18/01/2024 Effectiveness of Human Papillomavirus Vaccines (HPV) to prevent cervical, anal and oropharyngeal cancer: a target trial emulation analysis
17/01/2024 Diabetic ketoacidosis (DKA) in adults newly diagnosed with type 1 diabetes (T1D)
15/01/2024 What is the rate of occurrence of brief interventions in face to face versus remote consultations for adults in English primary care? An open cohort study of routinely collected healthcare data.
15/01/2024 The association between type 2 diabetes and glucose-lowering therapies and the risk of all-cause mortality and diabetes complications
12/01/2024 Epidemiology of Hypophosphatasia (HPP) in the UK: A Retrospective Cohort Study using Clinical Practice Research Data Link (CPRD)
12/01/2024 Population-level incidence, prevalence and mortality rates in diseases of regulatory interest
12/01/2024 Exploring Healthcare Use Trajectories and the Impact of Duloxetine on Pain-Related Healthcare Use in People with Fibromyalgia: Cohort Study and Emulated Trial in CPRD Aurum.
09/01/2024 Association between leukotriene receptor antagonist use and the risk of dementia: a population based cohort study
09/01/2024 Incidence of gastro-intestinal, lower respiratory tract, and acute otitis media infections in infants in the United Kingdom between 2012 and 2022.
09/01/2024 The epidemiology of sarcoidosis in the United Kingdon
08/01/2024 Calculating the impact of optimising preconception health among women with mental illness