Approved studies using CPRD Data

Access to CPRD data, including UK Primary Care Data, and linked data such as Hospital Episode Statistics, is subject to protocol approval via CPRD’s Research Data Governance (RDG) Process. Independent scientific and patient advice is provided by Expert Review Committees (ERCs) and the Central Advisory Committee (CAC). 

A summary of all approved protocols, including a lay and technical summary of the proposed research, is published three months after RDG approval. COVID-19 research protocols are being fast-tracked and all approved summaries are published within 72 hours to ensure transparency and to help avoid unnecessary duplication. 

Protocols below are listed in order of date of approval. Please click on the study title for more details. 

Peer-reviewed publications from research using CPRD data will be listed on our bibliography page

Approved studies using CPRD Data

Date of Approval Sort ascending Title
14/04/2021 Characterizing the changing morbidity and cause-specific mortality burden of the obesity epidemic in England and the UK
14/04/2021 Completeness and representativeness of ethnicity data in the UK Clinical Practice Research Datalink (CPRD) and Hospital Episode Statistics (HES)
11/04/2021 Predictors and outcomes of traumatic brain injury (concussion) in children
08/04/2021 Impact of the COVID-19 Crisis on Treatments, Natural History, Health Care Resource Utilisation, and Medical Cost in Hypertrophic Cardiomyopathy in England
07/04/2021 Validation of query definitions for a new or long-term course of antidepressant medications: a descriptive study.
07/04/2021 Estimating national and local prevalence of severe mental illnesses (SMI) and personality disorders (PD) in England: an exploratory study
07/04/2021 Variation in mental and physical health of children with long-term conditions or disability and their families: a longitudinal cohort study
06/04/2021 The clinical and economic burden of antibiotic use among paediatric patients with Varicella infection: a retrospective cohort analysis of real-world data in the UK
06/04/2021 Mortality and associated risk factors in individuals with and without type 1 and type 2 diabetes: A matched retrospective cohort study.
05/04/2021 Characterisation of multimorbidity clusters and trajectories using data-driven approaches in a nationally-representative population
30/03/2021 The nexus of diabetes, hypertension, and depression and its contribution to multimorbidity in United Kingdom
30/03/2021 The impact of systemic corticosteroids on major adverse cardiovascular events, solid-tumours and mortality in adults: a retrospective cohort study.
30/03/2021 Effectiveness of Indapamide Sustained Released on top of Perindopril on blood pressure change: a methodological study to validate effect of anti-hypertensive drugs in Clinical Research Practice Datalink
29/03/2021 Incidence and prevalence of Antiphospholipid Syndrome in United Kingdom.
25/03/2021 Retrospective database study to describe healthcare resource utilization in patients on antimuscarinics with overactive bladder in England
24/03/2021 Epidemiology and treatment of Myasthenia Gravis (MG): A retrospective study in Clinical Practice Research Datalink (CPRD) and Hospital Episodes Statistics (HES)
24/03/2021 The Role of Tuberculosis Disease on Non-Communicable Disease Risk: Comparative Analysis of Large Healthcare Databases
24/03/2021 The impact of systemic corticosteroids on diabetes mellitus and osteoporosis in adults: a retrospective cohort study
24/03/2021 The effectiveness of opicapone treatment compared to entacapone in Parkinson's disease using electronic primary healthcare records and linked secondary care data
24/03/2021 Trends in use of Glucose-lowering Medications in Patients with Type 2 Diabetes and Chronic Kidney Disease, 2000-2020