Approved studies using CPRD Data

Access to CPRD data, including UK Primary Care Data, and linked data such as Hospital Episode Statistics, is subject to protocol approval via CPRD’s Research Data Governance (RDG) Process. Independent scientific and patient advice is provided by Expert Review Committees (ERCs) and the Central Advisory Committee (CAC). 

A summary of all approved protocols, including a lay and technical summary of the proposed research, is published three months after RDG approval. COVID-19 research protocols are being fast-tracked and all approved summaries are published within 72 hours to ensure transparency and to help avoid unnecessary duplication. 

Protocols below are listed in order of date of approval. Please click on the study title for more details. 

Peer-reviewed publications from research using CPRD data will be listed on our bibliography page. 

Date of Approval	Title
23/05/2023	Assessing utilization rate, patient characteristics, and clinical and economic benefits of Oral Nutritional Supplement (ONS) with beta-hydroxy-beta-methylbutyrate (HMB) for adults at-risk or malnourished
22/05/2023	Direct oral anticoagulants and incidence of dementia in patients with nonvalvular atrial fibrillation.
22/05/2023	Epidemiology of hereditary spastic paraplegia in the United Kingdom
15/05/2023	Evaluation of the feasibility of conducting a non-interventional post-authorisation safety study (NI-PASS) of outcomes associated with the use of tacrolimus before conception or during pregnancy using real-world data
15/05/2023	Evaluation of risk prediction algorithms in CPRD Gold and Aurum
11/05/2023	Describing Pulmonary Rehabilitation referral and uptake for patients with Chronic Obstructive Pulmonary Disease
10/05/2023	Investigating within-individual variation in depression when measured using common depression questionnaires
10/05/2023	Mortality risk following lung cancer diagnosis in people with and without Type 2 Diabetes Mellitus
09/05/2023	Developing composite outcome or single outcome models for the prediction of adverse pregnancy complications; which prediction should be adopted for use in practice?
04/05/2023	Erectile dysfunction and the risk of glaucoma in men; a nested case-control study using English primary care data
04/05/2023	Burden of Pertussis among Adults in the UK A CPRD database study Phase I Feasibility Analysis
27/04/2023	The impact of weight change on disease burden in patients with obesity related multiple long-term conditions
27/04/2023	Characterisation of Medication Clusters Prior to and Following Dementia Diagnosis: A Population-Based Descriptive Study
27/04/2023	Associations between ethnicity, migration status and deprivation on the primary care service use of children and young people in the UK
25/04/2023	Non-cancer diagnoses and risk and costs of missed opportunities to diagnose symptomatic cancer: matched case-control and restrospective cohort studies
25/04/2023	Covid-19: impact on recorded incidence of cancer in England in the CPRD
24/04/2023	Feasibility study: To explore the risk of influenza hospitalization among different age groups during influenza seasons 2017-18, 2018-19, and 2019-20, in England
20/04/2023	The prevalence of autoimmune conditions among pregnant women and bidirectional association with pregnancy complications.
20/04/2023	Association between hypertensive disorders of pregnancy and dilated cardiomyopathy
20/04/2023	Network models for the prediction of adverse outcomes for patients with multimorbidity and polypharmacy