Approved studies using CPRD Data

Access to CPRD data, including UK Primary Care Data, and linked data such as Hospital Episode Statistics, is subject to protocol approval via CPRD’s Research Data Governance (RDG) Process. Independent scientific and patient advice is provided by Expert Review Committees (ERCs) and the Central Advisory Committee (CAC). 

A summary of all approved protocols, including a lay and technical summary of the proposed research, is published three months after RDG approval. COVID-19 research protocols are being fast-tracked and all approved summaries are published within 72 hours to ensure transparency and to help avoid unnecessary duplication. 

Protocols below are listed in order of date of approval. Please click on the study title for more details. 

Peer-reviewed publications from research using CPRD data will be listed on our bibliography page. 

Date of Approval	Title
12/03/2021	Characterising the young chronic obstructive pulmonary disease (COPD) patient in the United Kingdom: A descriptive study looking at clinical and aetiological factors utilising Clinical Practice Research Datalink (CPRD)
09/03/2021	CORYLUS UK: A retrospective observational cohort study of the impact of COVID-19 on systemic lupus erythematosus patients in England using data from linked primary and secondary care databases
09/03/2021	Respiratory Syncytial Virus (RSV) infections in England: estimating the burden of antibiotic prescriptions, healthcare utilisation and associated costs.
08/03/2021	WEiGht changes, caRdio-metabolic risks and mortality in patients with hypErThyroidism; all-cohort natural history and comparison of treatment effects in a CPRD-HES linked study. EGRET study
04/03/2021	Influence of allopurinol in addition to colchicine on Major Adverse Cardiac Events (MACE): a retrospective population-based cohort study
03/03/2021	Temporal trends in the incidence of common mental disorders in the United Kingdom by sociodemographic group (2000-2020)
02/03/2021	Does the association between multiple long-term conditions and mortality risk vary across sociodemographic groups?
01/03/2021	Ethnic differences in healthcare utilisation and care quality among people with multiple conditions
25/02/2021	Artificial intelligence for identifying new disease clusters in patients with immune-mediated inflammatory conditions: A Proof-of-Concept Study
25/02/2021	The Comparative Safety of Acid Suppressant Drugs: Is there an Increased Risk of Colorectal Cancer?
24/02/2021	CharacTeristics of treAtment response to hIgh dose inhaled corticosteroids(ICS)+Long acting B2 agonist(LABA) vs medium or high dOse ICS+LABA+long acting muscarinic antagonist in patients with uncontRolled moderate to severe asthma on medium dose ICS+LABA
23/02/2021	Prevalence, incidence, morbidity and mortality of early-onset type 2 diabetes.
22/02/2021	The direct and indirect effects of Covid-19 on long-term conditions: A retrospective cohort study using primary and secondary care electronic health records
18/02/2021	Effectiveness and safety of apixaban vs rivaroxaban in patients with Atrial Fibrillation and Diabetes Mellitus
18/02/2021	The effect of treatment intensification for type 2 diabetes on health outcomes in routine care and across highly granular patient subgroups: a regression discontinuity analysis
16/02/2021	Prognostic significance of initiating loop diuretics and its relationship to heart failure
16/02/2021	Association between weight loss and fertility in women diagnosed with polycystic ovary syndrome and living with overweight or obesity
15/02/2021	Investigating whether in utero exposure to maternal psychotropic medication is associated with adverse pregnancy outcomes and adverse health and neurodevelopmental outcomes in offspring
15/02/2021	Sulfonylureas versus metformin as initial treatment for type 2 diabetes and the risk of ventricular arrhythmia: A population-based cohort study
11/02/2021	COVID-19 recording in Clinical Practice Research Datalink primary care data and linked Second Generation Surveillance System SARS-CoV-2 virology test data