Approved studies using CPRD Data

Access to CPRD data, including UK Primary Care Data, and linked data such as Hospital Episode Statistics, is subject to protocol approval via CPRD’s Research Data Governance (RDG) Process. Independent scientific and patient advice is provided by Expert Review Committees (ERCs) and the Central Advisory Committee (CAC). 

A summary of all approved protocols, including a lay and technical summary of the proposed research, is published three months after RDG approval. COVID-19 research protocols are being fast-tracked and all approved summaries are published within 72 hours to ensure transparency and to help avoid unnecessary duplication. 

Protocols below are listed in order of date of approval. Please click on the study title for more details. 

Peer-reviewed publications from research using CPRD data will be listed on our bibliography page. 

Date of Approval	Title
13/10/2023	Incidence of stroke in patients with epilepsy using anti-seizure medication in England: A retrospective cohort study conducted within the Clinical Practice Research Datalink (CPRD)
10/10/2023	Cardiovascular mortality and morbidity in patients with chronic obstructive pulmonary disease, obstructive sleep apnoea and the overlap syndrome: a matched cohort study
10/10/2023	Sociodemographic factors, multimorbidity and frailty determinants in the delay of heart failure diagnosis, treatment and subsequent prognosis; UK trends over 20 years and impact of the Covid-19 pandemic
09/10/2023	Patient characteristics and treatment patterns in patients with asthma newly initiating Inhaled Corticosteroid (ICS) and Long-acting beta 2 agonist (LABA) combination inhalers in UK clinical practice
09/10/2023	Effects of the COVID-19 pandemic on primary care recorded anxiety and depression, psychotropic prescribing and referrals to mental health services
09/10/2023	Inequalities among marginalised groups, diagnosed with breast cancer, in relation to routes to diagnosis, diagnostic intervals, and pre-treatment intervals, before and after the COVID-19 pandemic: a cross-sectional analysis of national data
09/10/2023	DARWIN EU - EHDS Use Case: Natural history of coagulopathy in COVID-19 patients and persons vaccinated against SARS-CoV-2 in the context of the OMICRON variant, a population-based cohort study
05/10/2023	Exploring the standard of care among Very High Fracture Risk patients using Real World Data from Clinical Practice Research Datalink (CPRD) with linkage to Hospital Episode Statistics (HES) and Office for National Statistics (ONS) Death Registration
05/10/2023	Characterising and assessing long term outcomes in patients with prostate cancer
02/10/2023	Long-term mortality, neurodevelopmental impairments, and economic outcomes after invasive group B streptococcal disease in the first three months of life in England: A retrospective cohort study based on electronic health care records
02/10/2023	Analysis of chronic multimorbidity in observational data: part of the GEMINI study.
28/09/2023	Does the cumulative dose of aspirin affect cancer risk
28/09/2023	Predictors of discontinuation or reduction of long-term opioid therapy and its associated adverse events in patients with chronic non-cancer pain in the UK primary care: a retrospective cohort study
28/09/2023	Characterisation and treatment pathways of heavy menstrual bleeding using the Clinical Practice Research Datalink: a descriptive study
27/09/2023	Development and validation of risk scoring tools for acute exacerbations and cardiovascular outcomes among patients with chronic obstructive pulmonary disease (COPD).
27/09/2023	Demographic characteristics of a population with obesity, atherosclerotic cardiovascular disease, and no diabetes
27/09/2023	Identifying treatable traits of people with asthma prescribed an Inhaled Corticosteroid and Long Acing Beta-2 Agonist (ICS-LABA) - a descriptive analytic study in England
25/09/2023	A feasibility study to estimate subgroups of atrial fibrillation population
22/09/2023	Use of systemic fluoroquinolones in the UK: a drug utilisation study
22/09/2023	An observational study program to investigate the management and consequences of hyperkalemia in cardiorenal patients in routine clinical practice