Approved studies using CPRD Data

Access to CPRD data, including UK Primary Care Data, and linked data such as Hospital Episode Statistics, is subject to protocol approval via CPRD’s Research Data Governance (RDG) Process. Independent scientific and patient advice is provided by Expert Review Committees (ERCs) and the Central Advisory Committee (CAC). 

A summary of all approved protocols, including a lay and technical summary of the proposed research, is published three months after RDG approval. COVID-19 research protocols are being fast-tracked and all approved summaries are published within 72 hours to ensure transparency and to help avoid unnecessary duplication. 

Protocols below are listed in order of date of approval. Please click on the study title for more details. 

Peer-reviewed publications from research using CPRD data will be listed on our bibliography page. 

Date of Approval	Title
21/04/2016	The association between severe mental illness and chronic kidney disease: a cross sectional study
21/04/2016	A prevalence and incidence study of multimorbidity in the UK using the Clinical Practice Research Datalink (CPRD)
21/04/2016	Assessing drivers of effectiveness and safety using real life data: anticoagulants as a case study
21/04/2016	Determinants of exacerbations of asthma
21/04/2016	Prescribing patterns of dependence forming medicines: Benzodiazepines, z-drugs, opioids and GABAergic drugs
21/04/2016	Urinary tract infections in the elderly - care pathways and characteristics
29/04/2016	Premature mortality and non-fatal self-harm in patients diagnosed with Chronic Fatigue Syndrome
03/05/2016	Treatment choice and outcomes associated with dry powder inhaler and Tiotropium Respimat monotherapy in COPD (chronic obstructive pulmonary disease) patients
03/05/2016	Descriptive Epidemiology of Multimorbidity in Primary Care: A Cross-Sectional Study
05/05/2016	Examining changing patterns of antidepressant use in children, 2000 to 2015
05/05/2016	Androgen Deprivation Therapy for Prostate Cancer and the Risk of Anaemia
05/05/2016	Examining the impact of national guidelines on antipsychotic drug prescribing to older people with dementia
09/05/2016	Are primary care factors associated with hospital admissions for adverse drug reactions among the population with type 2 diabetes? A national observational study
10/05/2016	An observational evaluation of prescribing of fixed-dose combination inhaled corticosteroid / long-acting beta2-agonist (ICS/LABA): fluticasone propionate / formoterol (FP/FOR) and adverse events in routine primary care at 36-months post launch
10/05/2016	Development of small population prevalence models for COPD and asthma
11/05/2016	Mortality recording in the Clinical Practice Research Datalink
11/05/2016	Health Care Utilisation, Care Pathways and Educational Status in Children and Young People with Adolescent Mental Health Disorders
12/05/2016	Does the use of inhaled corticosteroids increase the incidence and disease burden of Type 2 Diabetes, osteoporosis or pneumonia compared to non-ICS therapies in patients with Chronic Obstructive Pulmonary Disease.
17/05/2016	Burden of medically attended acute gastroenteritis and aetiology: a cohort study in CPRD in England.
17/05/2016	Estimation of multi-treatment effects from observational data with application to diabetes mellitus