Approved studies using CPRD Data

Access to CPRD data, including UK Primary Care Data, and linked data such as Hospital Episode Statistics, is subject to protocol approval via CPRD’s Research Data Governance (RDG) Process. Independent scientific and patient advice is provided by Expert Review Committees (ERCs) and the Central Advisory Committee (CAC). 

A summary of all approved protocols, including a lay and technical summary of the proposed research, is published three months after RDG approval. COVID-19 research protocols are being fast-tracked and all approved summaries are published within 72 hours to ensure transparency and to help avoid unnecessary duplication. 

Protocols below are listed in order of date of approval. Please click on the study title for more details. 

Peer-reviewed publications from research using CPRD data will be listed on our bibliography page. 

Approved studies using CPRD Data

Date of Approval	Title
	Hormone Therapy in Relation to Risks of Second Cancers and Mortality Among Women and Men
	Oophorectomy and risk of primary liver cancer and fatty liver disease among women in the UK Clinical Practice Research Datalink
	RAASi use patterns following incident hyperkalemia in England
	Sub-optimal Asthma Control in patients treated with medium or high fixed dose combination of Inhaled Corticosteroid and Long Acting Beta-Agonists in the United Kingdom's Clinical Practice Research Datalink
	Aromatase inhibitors and risk of dementia in postmenopausal women with early-stage breast cancer: a retrospective cohort study in UK primary care
	What are the factors associated with missed opportunities to diagnose Chronic Obstructive Pulmonary Disease (COPD)? A non-interventional study using the Clinical Practice Research Datalink (CPRD) database.
	A prevalence and incidence study of multimorbidity in the UK using the Clinical Practice Research Datalink (CPRD)
	Discovering prognostic subtypes of cardiovascular diseases, using linked electronic healthcare records from 2 million people
	Three months versus 28 day prescriptions: a retrospective analysis of CPRD data to determine differences in the cost of drug wastage, dispensing fees and prescriber time
	Post-authorization Safety Study: Evaluation of Neoplasm Events in Users of Mirabegron and Other Treatments for Overactive Bladder in the CPRD
	Derivation and validation of statistical models to forecast acute death and longer term survival in people with cirrhosis
	Intra- and Post-operative Bleeding Events in Selected Operations in the English Inpatient Hospital Setting: Incidence, Risk Factors, and Impact on Length of Stay
	Quantifying the severity of chronic conditions in English Primary Care using the Clinical Practice Research Datalink
	Validation of the recording of asthma diagnosis in adult patients in the Clinical Practice Research Datalink
	Epidemiology of venous thromboembolism in patients with active cancer: a population-based cohort study
	Trimethoprim and sudden death in patients over 65 years with urinary tract infection
	Diabetes, use of metformin and the risk of meningioma
	Aclidinium Bromide Post-Authorisation Safety Study to Evaluate the Risk of Cardiovascular Endpoints: Mortality Study
	Investigating the cost effectiveness of alternative oral antiplatelet regimens in patients with type 2 diabetes in England.
	An evaluation of the epidemiology and burden of illness of food allergy in the United Kingdom