Approved studies using CPRD Data

Access to CPRD data, including UK Primary Care Data, and linked data such as Hospital Episode Statistics, is subject to protocol approval via CPRD’s Research Data Governance (RDG) Process. Independent scientific and patient advice is provided by Expert Review Committees (ERCs) and the Central Advisory Committee (CAC). 

A summary of all approved protocols, including a lay and technical summary of the proposed research, is published three months after RDG approval. COVID-19 research protocols are being fast-tracked and all approved summaries are published within 72 hours to ensure transparency and to help avoid unnecessary duplication. 

Protocols below are listed in order of date of approval. Please click on the study title for more details. 

Peer-reviewed publications from research using CPRD data will be listed on our bibliography page

Approved studies using CPRD Data

Date of Approval Sort descending Title
16/05/2016 Burden of medically attended acute gastroenteritis and aetiology: a cohort study in CPRD in England.
17/05/2016 An epidemiological study of Antiphospholipid Syndrome using electronic health records
17/05/2016 Development of an identification tool for patients over 65 years at risk of death or emergency hospital admission during cold weather.
22/05/2016 A Drug Utilisation Study of Rifaximin 550mg
22/05/2016 AED treatment sequencing and effectiveness in epilepsy patients, in real life clinical practice in England
22/05/2016 The utilization and toxicity profile of oral corticosteroids among asthma patients in the UK: an epidemiological study using Data from the Clinical Practice Research Datalink (CPRD).
25/05/2016 Discovering prognostic subtypes of cardiovascular diseases, using linked electronic healthcare records from 2 million people
25/05/2016 Long-term outcomes of NHS Health Checks in England.
31/05/2016 An investigation of the completeness and accuracy of the recording of stroke events (including by subtype) in primary (CPRD) and secondary care databases (HES and ONS)
31/05/2016 Use of blood eosinophil count to predict inhaled steroid responsiveness in patients with COPD using primary care health records
01/06/2016 PASS in patients with type 2 diabetes mellitus to assess the risk of acute liver injury, acute kidney injury and chronic kidney disease, severe complications of urinary tract infection, genital infections, and diabetic
01/06/2016 Development of small population prevalence model for heart failure
02/06/2016 A Joint Drug Utilisation Study (DUS) of valproate and related substances, in Europe, using databases
05/06/2016 Cataract in patients with diabetes mellitus
05/06/2016 Using pharmacoepidemiology to test medications associated with altered risk of breast cancer progression identified from connectivity mapping
05/06/2016 Estimating the risk of acute kidney injury associated with use of diuretics and renin angiotensin aldosterone system blockers in CPRD
08/06/2016 β-blocker effects on the association of hypoglycaemia with cardiovascular and all-cause mortality
08/06/2016 A retrospective database study of the prescribing of zonisamide in UK general practice: a drug utilisation study as part of post marketing safety surveillance.
13/06/2016 GLP-1 agonists and the risk of breast cancer in patients with type 2 diabetes
13/06/2016 Descriptive assessment of the Hospital Treatment Insights database and its link to the Clinical Practice Research Datalink for research on antibiotic dispensing in English hospitals