Approved studies using CPRD Data

Access to CPRD data, including UK Primary Care Data, and linked data such as Hospital Episode Statistics, is subject to protocol approval via CPRD’s Research Data Governance (RDG) Process. Independent scientific and patient advice is provided by Expert Review Committees (ERCs) and the Central Advisory Committee (CAC). 

A summary of all approved protocols, including a lay and technical summary of the proposed research, is published three months after RDG approval. COVID-19 research protocols are being fast-tracked and all approved summaries are published within 72 hours to ensure transparency and to help avoid unnecessary duplication. 

Protocols below are listed in order of date of approval. Please click on the study title for more details. 

Peer-reviewed publications from research using CPRD data will be listed on our bibliography page

Approved studies using CPRD Data

Date of Approval Sort ascending Title
25/05/2021 Comparative effects of different antidiabetic treatments on COVID-19 mortality and vascular outcomes
24/05/2021 Time to insulin initiation among second-line antidiabetics in a cohort of patients with type 2 diabetes
23/05/2021 Pharmacological treatments associated with increased or decreased risk of developing age-related macular degeneration: signal detection
23/05/2021 The impact of learning disabilities on control of type 2 diabetes risk factors and outcomes in UK primary care
19/05/2021 Real-World Effectiveness of Denosumab in Prevention of Fracture among Postmenopausal Osteoporotic Women with FREEDOM Baseline Characteristics
18/05/2021 Examining the change in risk of stroke and bleeding over time in patients with atrial fibrillation: A population-based cohort study using the Clinical Practice Research Datalink
18/05/2021 Comparison of modelling methods for risk prediction of cardiovascular outcomes in patients with hypertension
17/05/2021 Developing a methodological framework for the clinical prediction of multimorbidity
17/05/2021 Morbidity, mortality, resource use, and financial cost of pruritus in chronic kidney disease patients in the UK general population: a retrospective matched cohort study
12/05/2021 Maternal prescriptive drug use: the risks and benefits to mothers and neonates
12/05/2021 Antidementia drugs use in patients with Alzheimer's disease
12/05/2021 Effectiveness of triple therapy versus dual therapy in patients with chronic obstructive pulmonary disease who have had one severe or two or more moderate exacerbations within one year
11/05/2021 Health resource utilisation and cost burden of individuals with Amyotrophic Lateral Sclerosis (ALS) in England
11/05/2021 Investigating the influence of ethnicity in Atrial Fibrillation, focusing on the epidemiology, risk factors and outcomes; a population based study.
10/05/2021 Association between haemoglobin levels and clinical outcomes and healthcare resource use in patients with sickle cell disease in England
10/05/2021 Use of Glucagon-Like Peptide-1 Receptor Agonists and Sodium-Glucose Cotransporter-2 Inhibitors for the Prevention of Non-Alcoholic Fatty Liver Disease in Patients with Type 2 Diabetes
10/05/2021 The effect of diabetes mellitus on perioperative outcomes following colorectal resectional surgery
10/05/2021 Patient portal registration and healthcare utilisation outcomes of patients in the NHS General Practice.
07/05/2021 Natural history of coagulopathy and use of anti-thrombotic agents in COVID-19 patients: a cohort study
07/05/2021 Natural history of coagulopathy and use of anti-thrombotic agents in COVID-19 patients: a cohort study