00345nas a2200133   4500000000100000000000100001008004100002100001500043700001600058245010600074300001000180490000700190022001400197       2013                            d1 aC. Chapman1 aD. Bradshaw00aOnly modest long-term opioid dose escalation occurs over time in chronic nonmalignant pain management  a370-70 v27  a1536-0288