TY - JOUR KW - Young Adult KW - Humans KW - Male KW - Adolescent KW - Adult KW - Female KW - *Multimorbidity KW - Cross-Sectional Studies KW - Cluster Analysis KW - United Kingdom/epidemiology KW - *Patient Acceptance of Health Care AU - F. Eto AU - M. Samuel AU - R. Henkin AU - M. Mahesh AU - T. Ahmad AU - A. Angdembe AU - Hamish McAllister-Williams AU - P. Missier AU - Reynolds N AU - Barnes M AU - S. Hull AU - S. Finer AU - R. Mathur AD - Wolfson Institute of Population Health, Queen Mary University of London, London, United Kingdom. William Harvey Research Institute, Queen Mary University of London, London, United Kingdom. Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom. Translational and Clinical Research Institute, Newcastle University, Newcastle, United Kingdom. Northern Centre for Mood Disorders, Newcastle University, Newcastle, United Kingdom. Cumbria, Northumberland, Tyne and Wear NHS Foundation Trust, Newcastle, United Kingdom. Newcastle University, Newcastle, United Kingdom. AN - 37889900 BT - PLoS Med C2 - PMC10610074 contributions for their work on the Genes & Health programme, by a Life Sciences Consortium that includes Astra Zeneca PLC, Bristol-Myers Squibb Company, GlaxoSmithKline Research and Development Limited, Maze Therapeutics Inc, Merck Sharp & Dohme LLC, Novo Nordisk A/S, Pfizer Inc, Takeda Development Centre Americas Inc. RM is supported by Barts Charity (MGU0504). RM has received consulting fees from AMGEN unrelated to this work. RHM has received fees from American Center for Psychiatry & Neurology United Arab Emirates, British Association for Psychopharmacology, European College of Neuropsychopharmacology, International Society for Affective Disorders, Janssen, LivaNova, Lundbeck, My Tomorrows, OCM Comunicaziona s.n.c., Pfizer, Qatar International Mental Health Conference, Sunovion, Syntropharma, UK Medical Research Council and Wiley; grant support from National Institute for Health Research Efficacy and Mechanism Evaluation Panel and Health Technology Assessment Panel; and non-financial support from COMPASS Pathways and Magstim. PM is funded by the National Institute for Health Research (NIHR) Newcastle Biomedical Research Centre, by NIHR AIM AI-MULTIPLY, and by NIHR ADMISSION (MR/V033654/1). NJR is funded by the National Institute for Health Research (NIHR) Newcastle Biomedical Research Centre, by the NIHR Newcastle In Vitro Diagnostics Co-operative and NIHR AIM AI-MULTIPLY. N.J.R. is also a NIHR Senior Investigator, (Senior Investigator Award) NIHR200168. NJR reports grants from PSORT industrial partners as listed (http://www.psort.org.uk/); other research grants from GSK Stiefel and Novartis. MRB is funded by the National Institute for Health Research (NIHR) AIM AI-MULTIPLY Consortium (NIHR203982). MRB reports research grants from Benevolent AI, Janssen and Novartis. TA is funded by the NIHR Applied Research Collaboration North Thames Award (NIHR 200163). AA is funded by the NIHR (31672 AI-MULTIPLY, 2022-2025). RH is funded by the Health Data Research UK (grant ref: LOND1). DO - 10.1371/journal.pmed.1004300 DP - NLM ET - 2023/10/27 LA - eng M1 - 10 N1 - 1549-1676 Eto, Fabiola Orcid: 0000-0002-0203-8649 Samuel, Miriam Orcid: 0000-0003-1258-435x Henkin, Rafael Orcid: 0000-0002-5511-5230 Mahesh, Meera Orcid: 0009-0005-7417-2088 Ahmad, Tahania Orcid: 0000-0003-3117-4428 Angdembe, Alisha Hamish McAllister-Williams, R Orcid: 0000-0001-9966-1834 Missier, Paolo Orcid: 0000-0002-0978-2446 J Reynolds, Nick Orcid: 0000-0002-6484-825x R Barnes, Michael Orcid: 0000-0001-9097-7381 Hull, Sally Orcid: 0000-0002-8691-7519 Finer, Sarah Orcid: 0000-0002-2684-4653 Mathur, Rohini Orcid: 0000-0002-3817-8790 Journal Article United States PLoS Med. 2023 Oct 27;20(10):e1004300. doi: 10.1371/journal.pmed.1004300. eCollection 2023 Oct. PY - 2023 SN - 1549-1277 (Print) 1549-1277 EP - e1004300 T2 - PLoS Med TI - Ethnic differences in early onset multimorbidity and associations with health service use, long-term prescribing, years of life lost, and mortality: A cross-sectional study using clustering in the UK Clinical Practice Research Datalink VL - 20 ER -