%0 Journal Article %K Adult %K Aged %K COVID-19/*epidemiology/*mortality %K Female %K Humans %K Male %K Middle Aged %K Models, Statistical %K Mortality/*trends %K Pandemics %K Risk Factors %K SARS-CoV-2/pathogenicity %K Time Factors %K United Kingdom/epidemiology %B PLoS Med %D 2022 %G eng %M 34990450 %P e1003870 %R 10.1371/journal.pmed.1003870 %T Factors associated with excess all-cause mortality in the first wave of the COVID-19 pandemic in the UK: A time series analysis using the Clinical Practice Research Datalink %V 19 %2 PMC8735664 following competing interests: DAL provides expert advice to Legal & General through his membership of their scientific panel on longevity. HS, HC, BDS and KB have no interests to declare. %7 2022/01/07 %@ 1549-1277 (Print) 1549-1277