Research using CPRD data has informed drug safety guidance and clinical practice and resulted in over 2,600 peer-reviewed publications. The CPRD bibliography is updated on a monthly basis (last updated 4 January 2021) and papers are listed below and in the PDF below.

If you have published papers using CPRD data which are not included in this list, please contact us at so that we can update the bibliography.


 (PDF, 3MB, 218 pages) 

This work uses data provided by patients and collected by the NHS as part of their care and support. CPRD encourages researchers to use this citation in all publications using CPRD data. Find out more about acknowledging the use of patient data at the Understanding Patient Data website



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Author Title Type [ Year(Asc)]
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B. D. Nicholson, Hamilton, W., Koshiaris, C., Oke, J. L., Hobbs, F. D. R., and Aveyard, P., The association between unexpected weight loss and cancer diagnosis in primary care: a matched cohort analysis of 65,000 presentations, Br J Cancer, 2020.
C. Clarke, Hamilton, W., Price, S., and Bailey, S. E., Association of non-malignant diseases with thrombocytosis: a prospective cohort study in general practice, Br J Gen Pract, vol. 70, pp. e852-e857, 2020.
L. T. Mounce, Hamilton, W., and Bailey, S. E., Cancer incidence following a high-normal platelet count: cohort study using electronic healthcare records from English primary care, Br J Gen Pract, 2020.
S. Chowienczyk, Price, S., and Hamilton, W., Changes in the presenting symptoms of lung cancer from 2000-2017: a serial cross-sectional study of observational records in UK primary care, Br J Gen Pract, 2020.
G. Funston, Hamilton, W., Abel, G., Crosbie, E. J., Rous, B., and Walter, F. M., The diagnostic performance of CA125 for the detection of ovarian and non-ovarian cancer in primary care: A population-based cohort study, PLoS Med, vol. 17, p. e1003295, 2020.
M. Carney, Quiroga, M., Mounce, L., Shephard, E., Hamilton, W., and Price, S., Effect of pre-existing conditions on bladder cancer stage at diagnosis: a cohort study using electronic primary care records in the UK, Br J Gen Pract, 2020.
B. D. Nicholson, Aveyard, P., Price, S. J., Hobbs, F. R., Koshiaris, C., and Hamilton, W., Prioritising primary care patients with unexpected weight loss for cancer investigation: diagnostic accuracy study, Bmj, vol. 370, p. m2651, 2020.
J. Watson, Whiting, P., Salisbury, C., Banks, J., and Hamilton, W., Raised inflammatory markers as a predictor of one-year mortality: a cohort study in primary care in the UK using electronic health record data, BMJ Open, vol. 10, p. e036027, 2020.
S. Price, Spencer, A., Zhang, X., Ball, S., Lyratzopoulos, G., Mujica-Mota, R., Stapley, S., Ukoumunne, O. C., and Hamilton, W., Trends in time to cancer diagnosis around the period of changing national guidance on referral of symptomatic patients: A serial cross-sectional study using UK electronic healthcare records from 2006-17, Cancer Epidemiol, vol. 69, p. 101805, 2020.
J. Watson, Salisbury, C., Whiting, P., Banks, J., Pyne, Y., and Hamilton, W., Added value and cascade effects of inflammatory marker tests in UK primary care: a cohort study from the Clinical Practice Research Datalink, Br J Gen Pract, vol. 69, pp. e470-e478, 2019.
J. Watson, Salisbury, C., Banks, J., Whiting, P., and Hamilton, W., Predictive value of inflammatory markers for cancer diagnosis in primary care: a prospective cohort study using electronic health records, Br J Cancer, 2019.
T. Newlove-Delgado, Hamilton, W., Ford, T. J., Stein, K., and Ukoumunne, O. C., Prescribing for young people with attention deficit hyperactivity disorder in UK primary care: analysis of data from the Clinical Practice Research Datalink, Atten Defic Hyperact Disord, 2019.
T. Newlove-Delgado, Ford, T. J., Hamilton, W., Janssens, A., Stein, K., and Ukoumunne, O. C., Resumption of attention-deficit hyperactivity disorder medication in early adulthood: findings from a UK primary care prescribing study, Eur Child Adolesc Psychiatry, 2019.
J. Watson, Jones, H. E., Banks, J., Whiting, P., Salisbury, C., and Hamilton, W., Use of multiple inflammatory marker tests in primary care: using Clinical Practice Research Datalink to evaluate accuracy, Br J Gen Pract, vol. 69, pp. e462-e469, 2019.
M. Ozawa, Brennan, P. M., Zienius, K., Kurian, K. M., Hollingworth, W., Weller, D., Grant, R., Hamilton, W., and Ben-Shlomo, Y., The usefulness of symptoms alone or combined for general practitioners in considering the diagnosis of a brain tumour: a case-control study using the clinical practice research database (CPRD) (2000-2014), BMJ Open, vol. 9, p. e029686, 2019.
S. W. Merriel, Carroll, R., Hamilton, F., and Hamilton, W., Association between unexplained hypoalbuminaemia and new cancer diagnoses in UK primary care patients, Fam Pract, vol. 33, pp. 449-52, 2016.
A. W. Lim, Landy, R., Castanon, A., Hollingworth, A., Hamilton, W., Dudding, N., and Sasieni, P., Cytology in the diagnosis of cervical cancer in symptomatic young women: a retrospective review, Br J Gen Pract, vol. 66, pp. e871-e879, 2016.
A. W. Lim, Hamilton, W., Hollingworth, A., Stapley, S., and Sasieni, P., Performance characteristics of visualising the cervix in symptomatic young females: a review of primary care records in females with and without cervical cancer, Br J Gen Pract, vol. 66, pp. e189-92, 2016.
E. A. Shephard, Neal, R. D., Rose, P. W., Walter, F. M., and Hamilton, W., Symptoms of adult chronic and acute leukaemia before diagnosis: large primary care case-control studies using electronic records, Br J Gen Pract, vol. 66, pp. e182-8, 2016.
J. C. Robson, Kiran, A., Maskell, J., Hutchings, A., Arden, N., Dasgupta, B., Hamilton, W., Emin, A., Culliford, D., and Luqmani, R., Which Patients with Giant Cell Arteritis Will Develop Cardiovascular or Cerebrovascular Disease? A Clinical Practice Research Datalink Study, J Rheumatol, vol. 43, pp. 1085-92, 2016.
R. D. Neal, Din, N. U., Hamilton, W., Ukoumunne, O. C., Carter, B., Stapley, S., and Rubin, G., Comparison of cancer diagnostic intervals before and after implementation of NICE guidelines: analysis of data from the UK General Practice Research Database, Br J Cancer, vol. 110, pp. 584-92, 2014.
P. N. Taylor, Iqbal, A., Minassian, C., Sayers, A., Draman, M. S., Greenwood, R., Hamilton, W., Okosieme, O., Panicker, V., Thomas, S. L., and Dayan, C., Falling threshold for treatment of borderline elevated thyrotropin levels-balancing benefits and risks: evidence from a large community-based study, JAMA Intern Med, vol. 174, pp. 32-9, 2014.
S. Walker, Hyde, C., and Hamilton, W., Risk of breast cancer in symptomatic women in primary care: a case-control study using electronic records, Br J Gen Pract, vol. 64, pp. e788-93, 2014.
F. Hamilton, Carroll, R., Hamilton, W., and Salisbury, C., The risk of cancer in primary care patients with hypercalcaemia: a cohort study using electronic records, Br J Cancer, vol. 111, pp. 1410-2, 2014.
P. N. Taylor, Minassian, C., Rehman, A., Iqbal, A., Draman, M. S., Hamilton, W., Dunlop, D., Robinson, A., Vaidya, B., Lazarus, J. H., Thomas, S., Dayan, C. M., and Okosieme, O. E., TSH levels and risk of miscarriage in women on long-term levothyroxine: a community-based study, J Clin Endocrinol Metab, vol. 99, pp. 3895-902, 2014.
[Page last reviewed 5 January 2021]