Research using CPRD data has informed drug safety guidance and clinical practice and resulted in over 2,900 peer-reviewed publications. The CPRD bibliography is updated on a monthly basis (last updated 4 January 2022) and papers are listed below and in the PDF below.

If you have published papers using CPRD data which are not included in this list, please contact us at so that we can update the bibliography.


 (PDF, 6MB, 247 pages) 

This work uses data provided by patients and collected by the NHS as part of their care and support. CPRD encourages researchers to use this citation in all publications using CPRD data. Find out more about acknowledging the use of patient data at the Understanding Patient Data website



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Author Title [ Type(Desc)] Year
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Journal Article
L. Smeeth, Thomas, S. L., Hall, A. J., Hubbard, R., Farrington, P., and Vallance, P., Risk of myocardial infarction and stroke after acute infection or vaccination, N Engl J Med, vol. 351, pp. 2611-8, 2004.
S. M. Langan, Minassian, C., Smeeth, L., and Thomas, S. L., Risk of stroke following herpes zoster: a self-controlled case-series study, Clin Infect Dis, vol. 58, pp. 1497-503, 2014.
M. Schmidt, Mansfield, K. E., Bhaskaran, K., Nitsch, D., Sorensen, H. T., Smeeth, L., and Tomlinson, L. A., Serum creatinine elevation after renin-angiotensin system blockade and long term cardiorenal risks: cohort study, Bmj, vol. 356, p. j791, 2017.
R. J. Silverwood, Forbes, H. J., Abuabara, K., Ascott, A., Schmidt, M., Schmidt, S. A. J., Smeeth, L., and Langan, S. M., Severe and predominantly active atopic eczema in adulthood and long term risk of cardiovascular disease: population based cohort study, Bmj, vol. 361, p. k1786, 2018.
M. Iwagami, Mansfield, K. E., Hayes, J. F., Walters, K., Osborn, D. P., Smeeth, L., Nitsch, D., and Tomlinson, L. A., Severe mental illness and chronic kidney disease: a cross-sectional study in the United Kingdom, Clin Epidemiol, vol. 10, pp. 421-429, 2018.
K. Chidwick, Strongman, H., Matthews, A., Stanway, S., Lyon, A. R., Smeeth, L., and Bhaskaran, K., Statin use in cancer survivors versus the general population: cohort study using primary care data from the UK clinical practice research datalink, BMC Cancer, vol. 18, p. 1018, 2018.
A. F. Macedo, Douglas, I., Smeeth, L., Forbes, H., and Ebrahim, S., Statins and the risk of type 2 diabetes mellitus: cohort study using the UK clinical practice pesearch datalink, BMC Cardiovasc Disord, vol. 14, p. 85, 2014.
P. Bidulka, Fu, E. L., Leyrat, C., Kalogirou, F., McAllister, K. S. L., Kingdon, E. J., Mansfield, K. E., Iwagami, M., Smeeth, L., Clase, C. M., Bhaskaran, K., van Diepen, M., Carrero, J. J., Nitsch, D., and Tomlinson, L. A., Stopping renin-angiotensin system blockers after acute kidney injury and risk of adverse outcomes: parallel population-based cohort studies in English and Swedish routine care, BMC Med, vol. 18, p. 195, 2020.
E. Herrett, Williamson, E., Van Staa, T., Ranopa, M., Free, C., Chadborn, T., Goldacre, B., and Smeeth, L., Text messaging reminders for influenza vaccine in primary care: a cluster randomised controlled trial (TXT4FLUJAB), BMJ Open, vol. 6, p. e010069, 2016.
S. J. Sinnott, Smeeth, L., Williamson, E., and Douglas, I. J., Trends for prevalence and incidence of resistant hypertension: population based cohort study in the UK 1995-2015, Bmj, vol. 358, p. j3984, 2017.
J. L. Walker, Andrews, N. J., Mathur, R., Smeeth, L., and Thomas, S. L., Trends in the burden of varicella in UK general practice, Epidemiol Infect, vol. 145, pp. 2678-2682, 2017.
E. Crellin, Mansfield, K. E., Leyrat, C., Nitsch, D., Douglas, I. J., Root, A., Williamson, E., Smeeth, L., and Tomlinson, L. A., Trimethoprim use for urinary tract infection and risk of adverse outcomes in older patients: cohort study, Bmj, vol. 360, p. k341, 2018.
E. Herrett, George, J., Denaxas, S., Bhaskaran, K., Timmis, A., Hemingway, H., and Smeeth, L., Type and timing of heralding in ST-elevation and non-ST-elevation myocardial infarction: an analysis of prospectively collected electronic healthcare records linked to the national registry of acute coronary syndromes, Eur Heart J Acute Cardiovasc Care, vol. 2, pp. 235-45, 2013.
J. L. Walker, Grint, D. J., Strongman, H., Eggo, R. M., Peppa, M., Minassian, C., Mansfield, K. E., Rentsch, C. T., Douglas, I. J., Mathur, R., Wong, A. Y. S., Quint, J. K., Andrews, N., Bernal, J. L., Scott, J. A., Ramsay, M., Smeeth, L., and McDonald, H. I., UK prevalence of underlying conditions which increase the risk of severe COVID-19 disease: a point prevalence study using electronic health records, BMC Public Health, vol. 21, p. 484, 2021.
I. Douglas, Smeeth, L., and Irvine, D., The use of antidepressants and the risk of haemorrhagic stroke: a nested case control study, Br J Clin Pharmacol, vol. 71, pp. 116-20, 2011.
E. Herrett, Thomas, S. L., Schoonen, W. M., Smeeth, L., and Hall, A. J., Validation and validity of diagnoses in the General Practice Research Database: a systematic review, Br J Clin Pharmacol, vol. 69, pp. 4-14, 2010.
F. Nissen, Morales, D. R., Mullerova, H., Smeeth, L., Douglas, I. J., and Quint, J. K., Validation of asthma recording in the Clinical Practice Research Datalink (CPRD), BMJ Open, vol. 7, p. e017474, 2017.
J. K. Quint, Mullerova, H., DiSantostefano, R. L., Forbes, H., Eaton, S., Hurst, J. R., Davis, K., and Smeeth, L., Validation of chronic obstructive pulmonary disease recording in the Clinical Practice Research Datalink (CPRD-GOLD), BMJ Open, vol. 4, p. e005540, 2014.
E. Fombonne, Heavey, L., Smeeth, L., Rodrigues, L. C., Cook, C., Smith, P. G., Meng, L., and Hall, A. J., Validation of the diagnosis of autism in general practitioner records, BMC Public Health, vol. 4, p. 5, 2004.
K. J. Rothnie, Mullerova, H., Hurst, J. R., Smeeth, L., Davis, K., Thomas, S. L., and Quint, J. K., Validation of the Recording of Acute Exacerbations of COPD in UK Primary Care Electronic Healthcare Records, PLoS One, vol. 11, p. e0151357, 2016.
E. L. Herrett, Thomas, S. L., and Smeeth, L., Validity of diagnoses in the general practice research database, Br J Gen Pract, vol. 61, pp. 438-9, 2011.
R. Boggon, Hubbard, R., Smeeth, L., Gulliford, M., Cassell, J., Eaton, S., Pirmohamed, M., and van Staa, T. P., Variability of antibiotic prescribing in patients with chronic obstructive pulmonary disease exacerbations: a cohort study, BMC Pulm Med, vol. 13, p. 32, 2013.
T. P. van Staa, Smeeth, L., Persson, I., Parkinson, J., and Leufkens, H. G., What is the harm-benefit ratio of Cox-2 inhibitors?, Int J Epidemiol, vol. 37, pp. 405-13, 2008.
A. Jain, Walker, J. L., Mathur, R., Forbes, H. J., Langan, S. M., Smeeth, L., van Hoek, A. J., and Thomas, S. L., Zoster vaccination inequalities: A population based cohort study using linked data from the UK Clinical Practice Research Datalink, PLoS One, vol. 13, p. e0207183, 2018.
[Page last reviewed 4 January 2022]