Research using CPRD data has informed drug safety guidance and clinical practice and resulted in over 2,700 peer-reviewed publications. The CPRD bibliography is updated on a monthly basis (last updated 5 February 2021) and papers are listed below and in the PDF below.

If you have published papers using CPRD data which are not included in this list, please contact us at so that we can update the bibliography.


 (PDF, 3MB, 220 pages) 

This work uses data provided by patients and collected by the NHS as part of their care and support. CPRD encourages researchers to use this citation in all publications using CPRD data. Find out more about acknowledging the use of patient data at the Understanding Patient Data website



Export 2709 results:
Author Title [ Type(Desc)] Year
Journal Article
C. R. Meier, Schmitz, S., and Jick, H., Association between acetaminophen or nonsteroidal antiinflammatory drugs and risk of developing ovarian, breast, or colon cancer, Pharmacotherapy, vol. 22, pp. 303-9, 2002.
S. Hajat, Haines, A., Atkinson, R. W., Bremner, S. A., Anderson, H. R., and Emberlin, J., Association between air pollution and daily consultations with general practitioners for allergic rhinitis in London, United Kingdom, Am J Epidemiol, vol. 153, pp. 704-14, 2001.
G. Requena, Ma, L., Sturmer, T., Layton, J. B., and DiBello, J., Association Between an Acute, Drug-Induced Decrease in High-Density Lipoprotein Cholesterol Levels and Risk of Cardiovascular Events, Clin Drug Investig, 2020.
P. Kasteridis, Ride, J., Gutacker, N., Aylott, L., Dare, C., Doran, T., Gilbody, S., Goddard, M., Gravelle, H., Kendrick, T., Mason, A., Rice, N., Siddiqi, N., Williams, R., and Jacobs, R., Association Between Antipsychotic Polypharmacy and Outcomes for People With Serious Mental Illness in England, Psychiatr Serv, p. appips201800504, 2019.
G. Nakafero, Sanders, R. D., Nguyen-Van-Tam, J. S., and Myles, P. R., Association between benzodiazepine use and exacerbations and mortality in patients with asthma: a matched case-control and survival analysis using the United Kingdom Clinical Practice Research Datalink, Pharmacoepidemiol Drug Saf, vol. 24, pp. 793-802, 2015.
G. Nakafero, Sanders, R. D., Nguyen-Van-Tam, J. S., and Myles, P. R., The association between benzodiazepines and influenza-like illness-related pneumonia and mortality: a survival analysis using UK Primary Care data, Pharmacoepidemiol Drug Saf, vol. 25, pp. 1263-1273, 2016.
Y. B. Brauchli, Jick, S. S., Curtin, F., and Meier, C. R., Association between beta-blockers, other antihypertensive drugs and psoriasis: population-based case-control study, Br J Dermatol, vol. 158, pp. 1299-307, 2008.
D. Prieto-Alhambra, Javaid, M. K., Judge, A., Murray, D., Carr, A., Cooper, C., and Arden, N. K., Association between bisphosphonate use and implant survival after primary total arthroplasty of the knee or hip: population based retrospective cohort study, Bmj, vol. 343, p. d7222, 2011.
M. Kerkhof, Tran, T. N., van den Berge, M., Brusselle, G. G., Gopalan, G., Jones, R. C. M., Kocks, J. W. H., Menzies-Gow, A., Nuevo, J., Pavord, I. D., Rastogi, S., and Price, D. B., Association between blood eosinophil count and risk of readmission for patients with asthma: Historical cohort study, PLoS One, vol. 13, p. e0201143, 2018.
S. H. Landis, Pimenta, J. M., Yang, S., Compton, C., Barnes, N., and Brusselle, G., Association between blood eosinophils and acute exacerbation of COPD risk in patients with COPD in primary care, Respiratory Medicine, vol. 1, 2019.
C. R. Meier, Krahenbuhl, S., Schlienger, R. G., and Jick, H., Association between body mass index and liver disorders: an epidemiological study, J Hepatol, vol. 37, pp. 741-7, 2002.
G. Ronquist, Rodriguez, L. A., Ruigomez, A., Johansson, S., Wallander, M. A., Frithz, G., and Svardsudd, K., Association between captopril, other antihypertensive drugs and risk of prostate cancer, Prostate, vol. 58, pp. 50-6, 2004.
J. George, Majeed, W., Mackenzie, I. S., MacDonald, T. M., and Wei, L., Association between cardiovascular events and sodium-containing effervescent, dispersible, and soluble drugs: nested case-control study, Bmj, vol. 347, p. f6954, 2013.
R. Hiramatsu, Iwagami, M., and Nitsch, D., Association between chronic kidney disease and incident diagnosis of dementia in England: a cohort study in Clinical Practice Research Datalink, BMJ Open, vol. 10, p. e033811, 2020.
J. Ruzangi, Iwagami, M., Smeeth, L., Mangtani, P., and Nitsch, D., The association between chronic kidney disease and tuberculosis; a comparative cohort study in England, BMC Nephrol, vol. 21, p. 420, 2020.
C. E. Morton, Forbes, H. J., Pearce, N., Smeeth, L., and Warren-Gash, C., Association Between Common Infections and Incident Post-Stroke Dementia: A Cohort Study Using the Clinical Practice Research Datalink, Clin Epidemiol, vol. 12, pp. 907-916, 2020.
I. Barker, Steventon, A., and Deeny, S. R., Association between continuity of care in general practice and hospital admissions for ambulatory care sensitive conditions: cross sectional study of routinely collected, person level data, Bmj, vol. 356, p. j84, 2017.
M. Kerkhof, Voorham, J., Dorinsky, P., Cabrera, C., Darken, P., Kocks, J. W., Sadatsafavi, M., Sin, D. D., Carter, V., and Price, D. B., Association between COPD exacerbations and lung function decline during maintenance therapy, Thorax, 2020.
N. Dunn, Mullee, M., Perry, V. H., and Holmes, C., Association between dementia and infectious disease: evidence from a case-control study, Alzheimer Dis Assoc Disord, vol. 19, pp. 91-4, 2005.
V. Sazonov, Beetsch, J., Phatak, H., Wentworth, C., and Evans, M., Association between dyslipidemia and vascular events in patients treated with statins: report from the UK General Practice Research Database, Atherosclerosis, vol. 208, pp. 210-6, 2010.
C. L. Morgan, Mukherjee, J., Jenkins-Jones, S., Holden, S. E., and Currie, C. J., Association between first-line monotherapy with sulphonylurea versus metformin and risk of all-cause mortality and cardiovascular events: a retrospective, observational study, Diabetes Obes Metab, vol. 16, pp. 957-62, 2014.
P. A. Vissers, Cardwell, C. R., van de Poll-Franse, L. V., Young, I. S., Pouwer, F., and Murray, L. J., The association between glucose-lowering drug use and mortality among breast cancer patients with type 2 diabetes, Breast Cancer Res Treat, vol. 150, pp. 427-37, 2015.
J. Vavanikunnel, Charlier, S., Becker, C., Schneider, C., Jick, S. S., Meier, C. R., and Meier, C., Association between glycemic control and risk of fracture in diabetic patients: A nested case-control study, J Clin Endocrinol Metab, 2019.
G. Nakafero, Grainge, M. J., Myles, P. R., Mallen, C. D., Zhang, W., Doherty, M., Nguyen-Van-Tam, J. S., and Abhishek, A., Association between inactivated influenza vaccine and primary care consultations for autoimmune rheumatic disease flares: a self-controlled case series study using data from the Clinical Practice Research Datalink, Ann Rheum Dis, 2019.
S. E. Holden, Jenkins-Jones, S., and Currie, C. J., Association between Insulin Monotherapy versus Insulin plus Metformin and the Risk of All-Cause Mortality and Other Serious Outcomes: A Retrospective Cohort Study, PLoS One, vol. 11, p. e0153594, 2016.
R. Baker, Kendrick, D., Tata, L. J., and Orton, E., Association between maternal depression and anxiety episodes and rates of childhood injuries: a cohort study from England, Inj Prev, vol. 23, pp. 396-402, 2017.
G. Davey, Sedgwick, P., Maier, W., Visick, G., Strachan, D. P., and Anderson, H. R., Association between migraine and asthma: matched case-control study, Br J Gen Pract, vol. 52, pp. 723-7, 2002.
S. Hawley, Cordtz, R., Dreyer, L., Edwards, C. J., Arden, N. K., Delmestri, A., Silman, A., Cooper, C., Judge, A., and Prieto-Alhambra, D., Association between NICE guidance on biologic therapies with rates of hip and knee replacement among rheumatoid arthritis patients in England and Wales: An interrupted time-series analysis, Semin Arthritis Rheum, vol. 47, pp. 605-610, 2018.
D. Abrahami, Renoux, C., Yin, H., Fournier, J. P., and Azoulay, L., The Association between Oral Anticoagulants and Cancer Incidence among Individuals with Nonvalvular Atrial Fibrillation, Thromb Haemost, 2020.
C. S. Chui, Chan, E. W., Wong, A. Y., Root, A., Douglas, I. J., and Wong, I. C., Association between oral fluoroquinolones and seizures: A self-controlled case series study, Neurology, vol. 86, pp. 1708-15, 2016.
A. Skow, Douglas, I., and Smeeth, L., The association between Parkinson's disease and anti-epilepsy drug carbamazepine: a case-control study using the UK General Practice Research Database, Br J Clin Pharmacol, vol. 76, pp. 816-22, 2013.
A. Y. S. Wong, Froslev, T., Dearing, L., Forbes, H. J., Mulick, A., Mansfield, K. E., Silverwood, R. J., Kjaersgaard, A., Sorensen, H. T., Smeeth, L., Lewin, A., Schmidt, S. A. J., and Langan, S. M., The association between partner bereavement and melanoma: cohort studies in the U.K. and Denmark, Br J Dermatol, 2020.
R. Palladino, Tabak, A. G., Khunti, K., Valabhji, J., Majeed, A., Millett, C., and Vamos, E. P., Association between pre-diabetes and microvascular and macrovascular disease in newly diagnosed type 2 diabetes, BMJ Open Diabetes Res Care, vol. 8, 2020.
L. Wei, MacDonald, T., and Shimi, S., Association between prior appendectomy and/or tonsillectomy in women and subsequent pregnancy rate: a cohort study, Fertil Steril, vol. 106, pp. 1150-1156, 2016.
J. Spoendlin, Bichsel, F., Voegel, J. J., Jick, S. S., and Meier, C. R., The association between psychiatric diseases, psychotropic drugs and the risk of incident rosacea, Br J Dermatol, vol. 170, pp. 878-83, 2014.
F. J. de Abajo, Rodriguez, L. A., and Montero, D., Association between selective serotonin reuptake inhibitors and upper gastrointestinal bleeding: population based case-control study, Bmj, vol. 319, pp. 1106-9, 1999.
L. Alexandre, Clark, A. B., Bhutta, H. Y., Chan, S. S., Lewis, M. P., and Hart, A. R., Association Between Statin Use After Diagnosis of Esophageal Cancer and Survival: A Population-Based Cohort Study, Gastroenterology, vol. 150, pp. 854-65.e1; quiz e16-7, 2016.
D. J. Margolis, Hoffstad, O., and Isseroff, R. R., Association between the use of beta-adrenergic receptor agents and the development of venous leg ulcers, Arch Dermatol, vol. 143, pp. 1275-80, 2007.
S. G. Bruderer, Meier, C. R., Jick, S. S., and Bodmer, M., The association between thyroid disorders and incident gout: population-based case-control study, Clin Epidemiol, vol. 9, pp. 205-215, 2017.
Y. M. F. Andersen, Egeberg, A., Ban, L., Gran, S., Williams, H. C., Francis, N. A., Knop, F. K., Gislason, G. H., Skov, L., and Thyssen, J. P., Association Between Topical Corticosteroid Use and Type 2 Diabetes in Two European Population-Based Adult Cohorts, Diabetes Care, vol. 42, pp. 1095-1103, 2019.
B. D. Nicholson, Hamilton, W., Koshiaris, C., Oke, J. L., Hobbs, F. D. R., and Aveyard, P., The association between unexpected weight loss and cancer diagnosis in primary care: a matched cohort analysis of 65,000 presentations, Br J Cancer, 2020.
S. W. Merriel, Carroll, R., Hamilton, F., and Hamilton, W., Association between unexplained hypoalbuminaemia and new cancer diagnoses in UK primary care patients, Fam Pract, vol. 33, pp. 449-52, 2016.
A. M. van Strien, Souverein, P. C., Keijsers, C., Heerdink, E. R., Derijks, H. J., and van Marum, R. J., Association Between Urinary Tract Infections and Antipsychotic Drug Use in Older Adults, J Clin Psychopharmacol, vol. 38, pp. 296-301, 2018.
Y. B. Brauchli, Jick, S. S., Curtin, F., and Meier, C. R., Association between use of thiazolidinediones or other oral antidiabetics and psoriasis: A population based case-control study, J Am Acad Dermatol, vol. 58, pp. 421-9, 2008.
R. Williams, Kothny, W., Serban, C., Lopez-Leon, S., de Vries, F., and Schlienger, R., Association between vildagliptin and risk of angioedema, foot ulcers, skin lesions, hepatic toxicity, and serious infections in patients with type 2 diabetes mellitus: A European multidatabase, noninterventional, postauthorization safety study, Endocrinol Diabetes Metab, vol. 2, p. e00084, 2019.
K. Khunti, Danese, M. D., Kutikova, L., Catterick, D., Sorio-Vilela, F., Gleeson, M., Seshasai, S. R. Kondapa, Brownrigg, J., and Ray, K. K., Association of a Combined Measure of Adherence and Treatment Intensity With Cardiovascular Outcomes in Patients With Atherosclerosis or Other Cardiovascular Risk Factors Treated With Statins and/or Ezetimibe, JAMA Netw Open, vol. 1, p. e185554, 2018.
L. Li, Ambegaonkar, B. M., Reckless, J. P., and Jick, S., Association of a reduction in low-density lipoprotein cholesterol with incident cardiovascular and cerebrovascular events among people with type 2 diabetes mellitus, Eur J Prev Cardiol, vol. 21, pp. 855-65, 2014.
G. Baxter, Morgan, C. L., Jenkins-Jones, S., Currie, C. J., and Schultewolter, D., Association of Adverse Events And Health Service Usage With Tapentadol Prolonged-Release Treatment Compared With Morphine Controlled-Release (Cr) And Oxycodone Cr: A Uk Primary Care Observational Study, Value Health, vol. 18, p. A658, 2015.
S. Hajat, Haines, A., Goubet, S. A., Atkinson, R. W., and Anderson, H. R., Association of air pollution with daily GP consultations for asthma and other lower respiratory conditions in London, Thorax, vol. 54, pp. 597-605, 1999.
F. Montastruc, Nie, R., Loo, S., Rej, S., Dell'Aniello, S., Micallef, J., Suissa, S., and Renoux, C., Association of Aripiprazole With the Risk for Psychiatric Hospitalization, Self-harm, or Suicide, JAMA Psychiatry, 2019.
[Page last reviewed 4 February 2021]