Research using CPRD data has informed drug safety guidance and clinical practice and resulted in over 2,300 peer-reviewed publications.

The CPRD bibliography is updated on a monthly basis (last updated 4 October 2019) and papers are listed below and in the PDF below.

If you have published papers using CPRD data which are not included in this list, please contact us at so that we can update the bibliography.


(PDF, 3MB, 190 pages)


Export 2340 results:
Author Title [ Type(Desc)] Year
Journal Article
L. Wei, MacDonald, T., and Shimi, S., Association between prior appendectomy and/or tonsillectomy in women and subsequent pregnancy rate: a cohort study, Fertil Steril, vol. 106, pp. 1150-1156, 2016.
J. Spoendlin, Bichsel, F., Voegel, J. J., Jick, S. S., and Meier, C. R., The association between psychiatric diseases, psychotropic drugs and the risk of incident rosacea, Br J Dermatol, vol. 170, pp. 878-83, 2014.
F. J. de Abajo, Rodriguez, L. A., and Montero, D., Association between selective serotonin reuptake inhibitors and upper gastrointestinal bleeding: population based case-control study, Bmj, vol. 319, pp. 1106-9, 1999.
L. Alexandre, Clark, A. B., Bhutta, H. Y., Chan, S. S., Lewis, M. P., and Hart, A. R., Association Between Statin Use After Diagnosis of Esophageal Cancer and Survival: A Population-Based Cohort Study, Gastroenterology, vol. 150, pp. 854-65.e1; quiz e16-7, 2016.
W. G. Dixon, Suissa, S., and Hudson, M., The association between systemic glucocorticoid therapy and the risk of infection in patients with rheumatoid arthritis: systematic review and meta-analyses, Arthritis Res Ther, vol. 13, p. R139, 2011.
D. J. Margolis, Hoffstad, O., and Isseroff, R. R., Association between the use of beta-adrenergic receptor agents and the development of venous leg ulcers, Arch Dermatol, vol. 143, pp. 1275-80, 2007.
S. G. Bruderer, Meier, C. R., Jick, S. S., and Bodmer, M., The association between thyroid disorders and incident gout: population-based case-control study, Clin Epidemiol, vol. 9, pp. 205-215, 2017.
Y. M. F. Andersen, Egeberg, A., Ban, L., Gran, S., Williams, H. C., Francis, N. A., Knop, F. K., Gislason, G. H., Skov, L., and Thyssen, J. P., Association Between Topical Corticosteroid Use and Type 2 Diabetes in Two European Population-Based Adult Cohorts, Diabetes Care, vol. 42, pp. 1095-1103, 2019.
S. W. Merriel, Carroll, R., Hamilton, F., and Hamilton, W., Association between unexplained hypoalbuminaemia and new cancer diagnoses in UK primary care patients, Fam Pract, vol. 33, pp. 449-52, 2016.
A. M. van Strien, Souverein, P. C., Keijsers, C., Heerdink, E. R., Derijks, H. J., and van Marum, R. J., Association Between Urinary Tract Infections and Antipsychotic Drug Use in Older Adults, J Clin Psychopharmacol, vol. 38, pp. 296-301, 2018.
Y. B. Brauchli, Jick, S. S., Curtin, F., and Meier, C. R., Association between use of thiazolidinediones or other oral antidiabetics and psoriasis: A population based case-control study, J Am Acad Dermatol, vol. 58, pp. 421-9, 2008.
R. Williams, Kothny, W., Serban, C., Lopez-Leon, S., de Vries, F., and Schlienger, R., Association between vildagliptin and risk of angioedema, foot ulcers, skin lesions, hepatic toxicity, and serious infections in patients with type 2 diabetes mellitus: A European multidatabase, noninterventional, postauthorization safety study, Endocrinol Diabetes Metab, vol. 2, p. e00084, 2019.
K. Khunti, Danese, M. D., Kutikova, L., Catterick, D., Sorio-Vilela, F., Gleeson, M., Seshasai, S. R. Kondapa, Brownrigg, J., and Ray, K. K., Association of a Combined Measure of Adherence and Treatment Intensity With Cardiovascular Outcomes in Patients With Atherosclerosis or Other Cardiovascular Risk Factors Treated With Statins and/or Ezetimibe, JAMA Netw Open, vol. 1, p. e185554, 2018.
L. Li, Ambegaonkar, B. M., Reckless, J. P., and Jick, S., Association of a reduction in low-density lipoprotein cholesterol with incident cardiovascular and cerebrovascular events among people with type 2 diabetes mellitus, Eur J Prev Cardiol, vol. 21, pp. 855-65, 2014.
G. Baxter, Morgan, C. L., Jenkins-Jones, S., Currie, C. J., and Schultewolter, D., Association of Adverse Events And Health Service Usage With Tapentadol Prolonged-Release Treatment Compared With Morphine Controlled-Release (Cr) And Oxycodone Cr: A Uk Primary Care Observational Study, Value Health, vol. 18, p. A658, 2015.
S. Hajat, Haines, A., Goubet, S. A., Atkinson, R. W., and Anderson, H. R., Association of air pollution with daily GP consultations for asthma and other lower respiratory conditions in London, Thorax, vol. 54, pp. 597-605, 1999.
F. Montastruc, Nie, R., Loo, S., Rej, S., Dell'Aniello, S., Micallef, J., Suissa, S., and Renoux, C., Association of Aripiprazole With the Risk for Psychiatric Hospitalization, Self-harm, or Suicide, JAMA Psychiatry, 2019.
P. G. Iyer, Borah, B. J., Heien, H. C., Das, A., Cooper, G. S., and Chak, A., Association of Barrett's esophagus with type II Diabetes Mellitus: results from a large population-based case-control study, Clin Gastroenterol Hepatol, vol. 11, pp. 1108-1114.e5, 2013.
J. L. Faillie, Yu, O. H., Yin, H., Hillaire-Buys, D., Barkun, A., and Azoulay, L., Association of Bile Duct and Gallbladder Diseases With the Use of Incretin-Based Drugs in Patients With Type 2 Diabetes Mellitus, JAMA Intern Med, vol. 176, pp. 1474-1481, 2016.
K. Bhaskaran, dos-Santos-Silva, I., Leon, D. A., Douglas, I. J., and Smeeth, L., Association of BMI with overall and cause-specific mortality: a population-based cohort study of 3.6 million adults in the UK, Lancet Diabetes Endocrinol, vol. 6, pp. 944-953, 2018.
E. Hak, de Vries, T. W., Hoekstra, P. J., and Jick, S. S., Association of childhood attention-deficit/hyperactivity disorder with atopic diseases and skin infections? A matched case-control study using the General Practice Research Database, Ann Allergy Asthma Immunol, vol. 111, pp. 102-106.e2, 2013.
J. Browne, Edwards, D. A., Rhodes, K. M., Brimicombe, D. J., and Payne, R. A., Association of comorbidity and health service usage among patients with dementia in the UK: a population-based study, BMJ Open, vol. 7, p. e012546, 2017.
J. P. Sheppard, Stevens, S., Stevens, R. J., Mant, J., Martin, U., Hobbs, F. D. R., and McManus, R. J., Association of guideline and policy changes with incidence of lifestyle advice and treatment for uncomplicated mild hypertension in primary care: a longitudinal cohort study in the Clinical Practice Research Datalink, BMJ Open, vol. 8, p. e021827, 2018.
S. G. Bruderer, Bodmer, M., Jick, S. S., and Meier, C. R., Association of hormone therapy and incident gout: population-based case-control study, Menopause, vol. 22, pp. 1335-42, 2015.
H. B. Mehta, Mehta, V., and Goodwin, J. S., Association of Hypoglycemia With Subsequent Dementia in Older Patients With Type 2 Diabetes Mellitus, J Gerontol A Biol Sci Med Sci, vol. 72, pp. 1110-1116, 2017.
E. Hak, Shea, K. M., and Jick, S. S., Association of infant pneumococcal vaccination with pneumococcal pneumonia among mothers: a nested case-control study using the GPRD, Vaccine, vol. 31, pp. 1590-6, 2013.
J. M. Gamble, Chibrikov, E., Twells, L. K., Midodzi, W. K., Young, S. W., MacDonald, D., and Majumdar, S. R., Association of insulin dosage with mortality or major adverse cardiovascular events: a retrospective cohort study, Lancet Diabetes Endocrinol, vol. 5, pp. 43-52, 2017.
E. P. Vamos, Pape, U. J., Bottle, A., Hamilton, F. L., Curcin, V., Ng, A., Molokhia, M., Car, J., Majeed, A., and Millett, C., Association of practice size and pay-for-performance incentives with the quality of diabetes management in primary care, Cmaj, vol. 183, pp. E809-16, 2011.
A. Root, Brown, J. P., Forbes, H. J., Bhaskaran, K., Hayes, J., Smeeth, L., and Douglas, I. J., Association of Relative Age in the School Year With Diagnosis of Intellectual Disability, Attention-Deficit/Hyperactivity Disorder, and Depression, JAMA Pediatr, 2019.
C. Renoux, Vahey, S., Dell'Aniello, S., and Boivin, J. F., Association of Selective Serotonin Reuptake Inhibitors With the Risk for Spontaneous Intracranial Hemorrhage, JAMA Neurol, vol. 74, pp. 173-180, 2017.
S. K. Paul, Klein, K., Majeed, A., and Khunti, K., Association of smoking and concomitant metformin use with cardiovascular events and mortality in people newly diagnosed with type 2 diabetes, J Diabetes, vol. 8, pp. 354-62, 2016.
A. Alonso, Logroscino, G., Jick, S. S., and Hernan, M. A., Association of smoking with amyotrophic lateral sclerosis risk and survival in men and women: a prospective study, BMC Neurol, vol. 10, p. 6, 2010.
E. P. Vamos, Harris, M., Millett, C., Pape, U. J., Khunti, K., Curcin, V., Molokhia, M., and Majeed, A., Association of systolic and diastolic blood pressure and all cause mortality in people with newly diagnosed type 2 diabetes: retrospective cohort study, Bmj, vol. 345, p. e5567, 2012.
M. T. Redaniel, Gardner, M. P., Martin, R. M., and Jeffreys, M., The association of vitamin D supplementation with the risk of cancer in postmenopausal women, Cancer Causes Control, vol. 25, pp. 267-71, 2014.
E. Kontopantelis, Springate, D. A., Ashcroft, D. M., Valderas, J. M., van der Veer, S. N., Reeves, D., Guthrie, B., and Doran, T., Associations between exemption and survival outcomes in the UK's primary care pay-for-performance programme: a retrospective cohort study, BMJ Qual Saf, vol. 25, pp. 657-70, 2016.
M. Pujades-Rodriguez, Duyx, B., Thomas, S. L., Stogiannis, D., Smeeth, L., and Hemingway, H., Associations between polymyalgia rheumatica and giant cell arteritis and 12 cardiovascular diseases, Heart, vol. 102, pp. 383-9, 2016.
P. G. Kehoe, Davies, N. M., Martin, R. M., and Ben-Shlomo, Y., Associations of angiotensin targeting antihypertensive drugs with mortality and hospitalization in primary care patients with dementia, J Alzheimers Dis, vol. 33, pp. 999-1008, 2013.
B. Yang, Hagberg, K. W., Chen, J., Sahasrabuddhe, V. V., Graubard, B. I., Jick, S., and McGlynn, K. A., Associations of antibiotic use with risk of primary liver cancer in the Clinical Practice Research Datalink, Br J Cancer, vol. 115, pp. 85-9, 2016.
N. M. Davies, Kehoe, P. G., Ben-Shlomo, Y., and Martin, R. M., Associations of anti-hypertensive treatments with Alzheimer's disease, vascular dementia, and other dementias, J Alzheimers Dis, vol. 26, pp. 699-708, 2011.
S. Hajat and Haines, A., Associations of cold temperatures with GP consultations for respiratory and cardiovascular disease amongst the elderly in London, Int J Epidemiol, vol. 31, pp. 825-30, 2002.
B. Yang, Petrick, J. L., Chen, J., Hagberg, K. W., Sahasrabuddhe, V. V., Graubard, B. I., Jick, S., and McGlynn, K. A., Associations of NSAID and paracetamol use with risk of primary liver cancer in the Clinical Practice Research Datalink, Cancer Epidemiol, vol. 43, pp. 105-11, 2016.
M. T. Redaniel, Jeffreys, M., May, M. T., Ben-Shlomo, Y., and Martin, R. M., Associations of type 2 diabetes and diabetes treatment with breast cancer risk and mortality: a population-based cohort study among British women, Cancer Causes Control, vol. 23, pp. 1785-95, 2012.
S. R. Pye, Sheppard, T., Joseph, R. M., Lunt, M., Girard, N., Haas, J. S., Bates, D. W., Buckeridge, D. L., van Staa, T. P., Tamblyn, R., and Dixon, W. G., Assumptions made when preparing drug exposure data for analysis have an impact on results: An unreported step in pharmacoepidemiology studies, Pharmacoepidemiol Drug Saf, vol. 27, pp. 781-788, 2018.
C. Vasilakis-Scaramozza, Aschengrau, A., Cabral, H. J., and Jick, S. S., Asthma drugs and the risk of congenital anomalies, Pharmacotherapy, vol. 33, pp. 363-8, 2013.
R. A. Charlton, Hutchison, A., Davis, K. J., and de Vries, C. S., Asthma management in pregnancy, PLoS One, vol. 8, p. e60247, 2013.
R. A. Charlton, Pierini, A., Klungsoyr, K., Neville, A. J., Jordan, S., van den Berg, L. T. de Jong, Thayer, D., Bos, H. J., Puccini, A., Hansen, A. V., Gini, R., Engeland, A., Andersen, A. M. Nybo, Dolk, H., and Garne, E., Asthma medication prescribing before, during and after pregnancy: a study in seven European regions, BMJ Open, vol. 6, p. e009237, 2016.
Y. Schonmann, Mansfield, K. E., Hayes, J. F., Abuabara, K., Roberts, A., Smeeth, L., and Langan, S. M., Atopic eczema in adulthood and risk of depression and anxiety: a population-based cohort study, J Allergy Clin Immunol Pract, 2019.
A. C. Scowcroft and Cowie, M. R., Atrial fibrillation: improvement in identification and stroke preventive therapy - data from the UK Clinical Practice Research Datalink, 2000-2012, Int J Cardiol, vol. 171, pp. 169-73, 2014.
S. McCarthy, Asherson, P., Coghill, D., Hollis, C., Murray, M., Potts, L., Sayal, K., de Soysa, R., Taylor, E., Williams, T., and Wong, I. C., Attention-deficit hyperactivity disorder: treatment discontinuation in adolescents and young adults, Br J Psychiatry, vol. 194, pp. 273-7, 2009.
V. Prasad, West, J., Kendrick, D., and Sayal, K., Attention-deficit/hyperactivity disorder: variation by socioeconomic deprivation, Arch Dis Child, 2018.
[Page last reviewed 4 October 2019]