Bibliography

Research using CPRD data has informed drug safety guidance and clinical practice and resulted in over 2,300 peer-reviewed publications.

The CPRD bibliography is updated on a monthly basis (last updated 4 November 2019) and papers are listed below and in the PDF below.

If you have published papers using CPRD data which are not included in this list, please contact us at enquiries@cprd.com so that we can update the bibliography.

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J. A. Delaney, Moodie, E. E., and Suissa, S., Validating the effects of drug treatment on blood pressure in the General Practice Research Database, Pharmacoepidemiol Drug Saf, vol. 17, pp. 535-45, 2008.
E. Herrett, Thomas, S. L., Schoonen, W. M., Smeeth, L., and Hall, A. J., Validation and validity of diagnoses in the General Practice Research Database: a systematic review, Br J Clin Pharmacol, vol. 69, pp. 4-14, 2010.
F. Nissen, Morales, D. R., Mullerova, H., Smeeth, L., Douglas, I. J., and Quint, J. K., Validation of asthma recording in the Clinical Practice Research Datalink (CPRD), BMJ Open, vol. 7, p. e017474, 2017.
K. W. Hagberg and Jick, S. S., Validation of autism spectrum disorder diagnoses recorded in the Clinical Practice Research Datalink, 1990-2014, Clin Epidemiol, vol. 9, pp. 475-482, 2017.
A. V. Margulis, Fortuny, J., Kaye, J. A., Calingaert, B., Reynolds, M., Plana, E., McQuay, L. J., Atsma, W. J., Franks, B., de Vogel, S., Perez-Gutthann, S., and Arana, A., Validation of Cancer Cases Using Primary Care, Cancer Registry, and Hospitalization Data in the United Kingdom, Epidemiology, vol. 29, pp. 308-313, 2018.
J. K. Quint, Mullerova, H., DiSantostefano, R. L., Forbes, H., Eaton, S., Hurst, J. R., Davis, K., and Smeeth, L., Validation of chronic obstructive pulmonary disease recording in the Clinical Practice Research Datalink (CPRD-GOLD), BMJ Open, vol. 4, p. e005540, 2014.
R. J. Ferguson, Prieto-Alhambra, D., Walker, C., Yu, D., Valderas, J. M., Judge, A., Griffiths, J., Jordan, K. P., Peat, G., Glyn-Jones, S., and Silman, A. J., Validation of hip osteoarthritis diagnosis recording in the UK Clinical Practice Research Datalink, Pharmacoepidemiol Drug Saf, 2018.
H. Jick, Jick, S. S., and Derby, L. E., Validation of information recorded on general practitioner based computerised data resource in the United Kingdom, Bmj, vol. 302, pp. 766-8, 1991.
S. Devine, West, S. L., Andrews, E., Tennis, P., Eaton, S., Thorp, J., and Olshan, A., Validation of neural tube defects in the full featured–general practice research database, Pharmacoepidemiol Drug Saf, vol. 17, pp. 434-44, 2008.
N. Frey, Bircher, A., Bodmer, M., Jick, S. S., Meier, C. R., and Spoendlin, J., Validation of Stevens-Johnson syndrome or toxic epidermal necrolysis diagnoses in the Clinical Practice Research Datalink, Pharmacoepidemiol Drug Saf, vol. 26, pp. 429-436, 2017.
K. H. Thomas, Davies, N., Metcalfe, C., Windmeijer, F., Martin, R. M., and Gunnell, D., Validation of suicide and self-harm records in the Clinical Practice Research Datalink, Br J Clin Pharmacol, vol. 76, pp. 145-57, 2013.
E. Fombonne, Heavey, L., Smeeth, L., Rodrigues, L. C., Cook, C., Smith, P. G., Meng, L., and Hall, A. J., Validation of the diagnosis of autism in general practitioner records, BMC Public Health, vol. 4, p. 5, 2004.
R. Lawrenson, Todd, J. C., Leydon, G. M., Williams, T. J., and Farmer, R. D., Validation of the diagnosis of venous thromboembolism in general practice database studies, Br J Clin Pharmacol, vol. 49, pp. 591-6, 2000.
K. J. Rothnie, Mullerova, H., Hurst, J. R., Smeeth, L., Davis, K., Thomas, S. L., and Quint, J. K., Validation of the Recording of Acute Exacerbations of COPD in UK Primary Care Electronic Healthcare Records, PLoS One, vol. 11, p. e0151357, 2016.
C. J. Crooks, West, J., and Jepsen, P., A validation study of the CirCom comorbidity score in an English cirrhosis population using the Clinical Practice Research Datalink, Clin Epidemiol, vol. 10, pp. 107-120, 2018.
J. D. Lewis, Brensinger, C., Bilker, W. B., and Strom, B. L., Validity and completeness of the General Practice Research Database for studies of inflammatory bowel disease, Pharmacoepidemiol Drug Saf, vol. 11, pp. 211-8, 2002.
K. J. Rothnie, Chandan, J. S., Goss, H. G., Mullerova, H., and Quint, J. K., Validity and interpretation of spirometric recordings to diagnose COPD in UK primary care, Int J Chron Obstruct Pulmon Dis, vol. 12, pp. 1663-1668, 2017.
A. Dregan, Moller, H., Murray-Thomas, T., and Gulliford, M. C., Validity of cancer diagnosis in a primary care database compared with linked cancer registrations in England. Population-based cohort study, Cancer Epidemiol, vol. 36, pp. 425-9, 2012.
E. L. Herrett, Thomas, S. L., and Smeeth, L., Validity of diagnoses in the general practice research database, Br J Gen Pract, vol. 61, pp. 438-9, 2011.
M. E. Saine, Gizaw, M., Carbonari, D. M., Newcomb, C. W., Roy, J. A., Cardillo, S., Esposito, D. B., Bhullar, H., Gallagher, A. M., Strom, B. L., and , Validity of diagnostic codes to identify hospitalizations for infections among patients treated with oral anti-diabetic drugs, Pharmacoepidemiol Drug Saf, 2017.
N. F. Khan, Harrison, S. E., and Rose, P. W., Validity of diagnostic coding within the General Practice Research Database: a systematic review, Br J Gen Pract, vol. 60, pp. e128-36, 2010.
M. Iwagami, Tomlinson, L. A., Mansfield, K. E., Casula, A., Caskey, F. J., Aitken, G., Fraser, S. D. S., Roderick, P. J., and Nitsch, D., Validity of estimated prevalence of decreased kidney function and renal replacement therapy from primary care electronic health records compared with national survey and registry data in the United Kingdom, Nephrol Dial Transplant, vol. 32, pp. ii142-ii150, 2017.
L. Li, Setoguchi, S., and Jick, S., Validity of non-fatal idiopathic serious ventricular arrhythmia in UK-based Clinical Practice Research Datalink, Pharmacoepidemiol Drug Saf, vol. 23, pp. 999-1001, 2014.
H. P. Booth, Prevost, A. T., and Gulliford, M. C., Validity of smoking prevalence estimates from primary care electronic health records compared with national population survey data for England, 2007 to 2011, Pharmacoepidemiol Drug Saf, vol. 22, pp. 1357-61, 2013.
S. S. Jick, Kaye, J. A., Vasilakis-Scaramozza, C., Rodriguez, L. A. Garcia, Ruigomez, A., Meier, C. R., Schlienger, R. G., Black, C., and Jick, H., Validity of the general practice research database, Pharmacotherapy, vol. 23, pp. 686-9, 2003.
S. F. Weng, Kai, J., Guha, I. N., and Qureshi, N., The value of aspartate aminotransferase and alanine aminotransferase in cardiovascular disease risk assessment, Open Heart, vol. 2, p. e000272, 2015.
A. V. Margulis, Fortuny, J., Kaye, J. A., Calingaert, B., Reynolds, M., Plana, E., McQuay, L. J., Atsma, W. J., Franks, B., de Vogel, S., Perez-Gutthann, S., and Arana, A., Value of Free-text Comments for Validating Cancer Cases Using Primary-care Data in the United Kingdom, Epidemiology, vol. 29, pp. e41-e42, 2018.
R. D. Mann, The VAMP system and the detection of risk, some examples, Pharmacoepidemiology and Drug Safety, vol. 3, pp. 313-319, 1994.
D. Gunnell, Irvine, D., Wise, L., Davies, C., and Martin, R. M., Varenicline and suicidal behaviour: a cohort study based on data from the General Practice Research Database, Bmj, vol. 339, p. b3805, 2009.
D. Henry, Lim, L. L., Rodriguez, L. A. Garcia, S. Gutthann, P., Carson, J. L., Griffin, M., Savage, R., Logan, R., Moride, Y., Hawkey, C., Hill, S., and Fries, J. T., Variability in risk of gastrointestinal complications with individual non-steroidal anti-inflammatory drugs: results of a collaborative meta-analysis, Bmj, vol. 312, pp. 1563-6, 1996.
R. Boggon, Hubbard, R., Smeeth, L., Gulliford, M., Cassell, J., Eaton, S., Pirmohamed, M., and van Staa, T. P., Variability of antibiotic prescribing in patients with chronic obstructive pulmonary disease exacerbations: a cohort study, BMC Pulm Med, vol. 13, p. 32, 2013.
A. Arana, Margulis, A. V., McQuay, L. J., Ziemiecki, R., Bartsch, J. L., Rothman, K. J., Franks, B., D'Silva, M., Appenteng, K., Varas-Lorenzo, C., and Perez-Gutthann, S., Variation in Cardiovascular Risk Related to Individual Antimuscarinic Drugs Used to Treat Overactive Bladder: A UK Cohort Study, Pharmacotherapy, vol. 38, pp. 628-637, 2018.
D. J. Humes, Walker, A. J., Blackwell, J., Hunt, B. J., and West, J., Variation in the risk of venous thromboembolism following colectomy, Br J Surg, vol. 102, pp. 1629-38, 2015.
A. J. Walker, West, J., Card, T. R., Humes, D. J., and Grainge, M. J., Variation in the risk of venous thromboembolism in people with colorectal cancer: a population-based cohort study from England, J Thromb Haemost, vol. 12, pp. 641-9, 2014.
M. Ashworth, Charlton, J., Ballard, K., Latinovic, R., and Gulliford, M., Variations in antibiotic prescribing and consultation rates for acute respiratory infection in UK general practices 1995-2000, Br J Gen Pract, vol. 55, pp. 603-8, 2005.
D. J. Margolis, Bilker, W., Santanna, J., and Baumgarten, M., Venous leg ulcer: incidence and prevalence in the elderly, J Am Acad Dermatol, vol. 46, pp. 381-6, 2002.
R. Lawrenson and Farmer, R., Venous thromboembolism and combined oral contraceptives: does the type of progestogen make a difference?, Contraception, vol. 62, p. 21S-28S; discussion 37S-38S, 2000.
H. E. Seaman, Langley, S. E., Farmer, R. D., and de Vries, C. S., Venous thromboembolism and cyproterone acetate in men with prostate cancer: a study using the General Practice Research Database, BJU Int, vol. 99, pp. 1398-403, 2007.
U. T. Khan, Walker, A. J., Baig, S., Card, T. R., Kirwan, C. C., and Grainge, M. J., Venous thromboembolism and mortality in breast cancer: cohort study with systematic review and meta-analysis, BMC Cancer, vol. 17, p. 747, 2017.
H. E. Seaman, de Vries, C. S., and Farmer, R. D., Venous thromboembolism associated with cyproterone acetate in combination with ethinyloestradiol (Dianette): observational studies using the UK General Practice Research Database, Pharmacoepidemiol Drug Saf, vol. 13, pp. 427-36, 2004.
I. Little, Vinogradova, Y., Orton, E., Kai, J., and Qureshi, N., Venous thromboembolism in adults screened for sickle cell trait: a population-based cohort study with nested case-control analysis, BMJ Open, vol. 7, p. e012665, 2017.
A. A. Sultan, Muller, S., Whittle, R., Roddy, E., Mallen, C., and Clarson, L., Venous thromboembolism in patients with gout and the impact of hospital admission, disease duration and urate-lowering therapy, Cmaj, vol. 191, pp. E597-e603, 2019.
C. Renoux, Dell'Aniello, S., Khairy, P., Marras, C., Bugden, S., Turin, T. C., Blais, L., Tamim, H., Evans, C., Steele, R., Dormuth, C., and Ernst, P., Ventricular tachyarrhythmia and sudden cardiac death with domperidone use in Parkinson's disease, Br J Clin Pharmacol, vol. 82, pp. 461-72, 2016.
W
L. Watson, Wilson, B. P., Alsop, J., and Kumar, S., Weight and glycaemic control in type 2 diabetes: what is the outcome of insulin initiation?, Diabetes Obes Metab, vol. 13, pp. 823-31, 2011.
A. M. Mueller, Meier, C. R., Jick, S. S., and Schneider, C., Weight change and blood glucose concentration as markers for pancreatic cancer in subjects with new-onset diabetes mellitus: A matched case-control study, Pancreatology, 2019.
B. T. Blak, Rigney, U., Sternhufvud, C., Davis, J., and Hammar, N., Weight change and healthcare resource use in English patients with type 2 diabetes mellitus initiating a new diabetes medication class, Int J Clin Pract, vol. 70, pp. 45-55, 2016.
N. M. Davies, Taylor, G., Taylor, A. E., Thomas, K. H., Windmeijer, F., Martin, R. M., and Munafo, M. R., What are the effects of varenicline compared with nicotine replacement therapy on long-term smoking cessation and clinically important outcomes? Protocol for a prospective cohort study, BMJ Open, vol. 5, p. e009665, 2015.
D. Kernick, Stapley, S., Campbell, J., and Hamilton, W., What happens to new-onset headache in children that present to primary care? A case-cohort study using electronic primary care records, Cephalalgia, vol. 29, pp. 1311-6, 2009.
G. E. Smith, Smith, S., Heatlie, H., Bashford, J. N., Hawker, J., Ashcroft, D., Millson, D., Verlander, N. Q., and Warren, R., What has happened to antimicrobial usage in primary care in the United Kingdom since the SMAC report? - description of trends in antimicrobial usage using the General Practice Research Database, J Public Health (Oxf), vol. 26, pp. 359-64, 2004.
T. P. van Staa, Smeeth, L., Persson, I., Parkinson, J., and Leufkens, H. G., What is the harm-benefit ratio of Cox-2 inhibitors?, Int J Epidemiol, vol. 37, pp. 405-13, 2008.
[Page last reviewed 4 November 2019]