Research using CPRD data has informed drug safety guidance and clinical practice and resulted in over 2,300 peer-reviewed publications.

The CPRD bibliography is updated on a monthly basis (last updated 4 December 2019) and papers are listed below and in the PDF below.

If you have published papers using CPRD data which are not included in this list, please contact us at so that we can update the bibliography.


(PDF, 3MB, 193 pages)


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Author [ Title(Asc)] Type Year
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E. M. van Soest, Valkhoff, V. E., Mazzaglia, G., Schade, R., Molokhia, M., Goldstein, J. L., Hernandez-Diaz, S., Trifiro, G., Dieleman, J. P., Kuipers, E. J., and Sturkenboom, M. C., Suboptimal gastroprotective coverage of NSAID use and the risk of upper gastrointestinal bleeding and ulcers: an observational study using three European databases, Gut, vol. 60, pp. 1650-9, 2011.
R. K. Akyea, Kai, J., Qureshi, N., Iyen, B., and Weng, S. F., Sub-optimal cholesterol response to initiation of statins and future risk of cardiovascular disease, Heart, 2019.
N. A. Stohler, Reinau, D., Jick, S. S., Bodmer, D., and Meier, C. R., A study on the epidemiology of tinnitus in the United Kingdom, Clin Epidemiol, vol. 11, pp. 855-871, 2019.
J. Spoendlin, Voegel, J. J., Jick, S. S., and Meier, C. R., A study on the epidemiology of rosacea in the U.K, Br J Dermatol, vol. 167, pp. 598-605, 2012.
S. S. Jick, Vasilakis, C., Martinez, C., and Jick, H., A study of the relation of exposure to quinolones and suicidal behaviour, Br J Clin Pharmacol, vol. 45, pp. 77-81, 1998.
R. D. Mann, Lis, Y., Chukwujindu, J., and Chanter, D. O., A study of the association between hormone replacement therapy, smoking and the occurrence of myocardial infarction in women, J Clin Epidemiol, vol. 47, pp. 307-12, 1994.
S. Norton, Koduri, G., Nikiphorou, E., Dixey, J., Williams, P., and Young, A., A study of baseline prevalence and cumulative incidence of comorbidity and extra-articular manifestations in RA and their impact on outcome, Rheumatology (Oxford), vol. 52, pp. 99-110, 2013.
T. P. van Staa and Sprafka, J. M., Study of adverse outcomes in women using testosterone therapy, Maturitas, vol. 62, pp. 76-80, 2009.
A. Pate, Barrowman, M., Webb, D., Pimenta, J. M., Davis, K. J., Williams, R., Van Staa, T., and Sperrin, M., Study investigating the generalisability of a COPD trial based in primary care (Salford Lung Study) and the presence of a Hawthorne effect, BMJ Open Respir Res, vol. 5, p. e000339, 2018.
J. Fortuny, Gilsenan, A., Cainzos-Achirica, M., Cantero, O. F., Flynn, R. W. V., Garcia-Rodriguez, L., Kollhorst, B., Karlsson, P., Linner, L., MacDonald, T. M., Plana, E., Ruigomez, A., Schink, T., Ziemiecki, R., and Andrews, E. B., Study Design and Cohort Comparability in a Study of Major Cardiovascular Events in New Users of Prucalopride Versus Polyethylene Glycol 3350, Drug Saf, 2019.
J. R. Hardy, Holford, T. R., Hall, G. C., and Bracken, M. B., Strategies for identifying pregnancies in the automated medical records of the General Practice Research Database, Pharmacoepidemiol Drug Saf, vol. 13, pp. 749-59, 2004.
S. Hernandez-Diaz and Rodriguez, L. A., Steroids and risk of upper gastrointestinal complications, Am J Epidemiol, vol. 153, pp. 1089-93, 2001.
A. McGrogan, Snowball, J., and Charlton, R. A., Statins during pregnancy: a cohort study using the General Practice Research Database to investigate pregnancy loss, Pharmacoepidemiol Drug Saf, vol. 26, pp. 843-852, 2017.
A. F. Macedo, Douglas, I., Smeeth, L., Forbes, H., and Ebrahim, S., Statins and the risk of type 2 diabetes mellitus: cohort study using the UK clinical practice pesearch datalink, BMC Cardiovasc Disord, vol. 14, p. 85, 2014.
R. G. Schlienger, Fedson, D. S., Jick, S. S., Jick, H., and Meier, C. R., Statins and the risk of pneumonia: a population-based, nested case-control study, Pharmacotherapy, vol. 27, pp. 325-32, 2007.
C. C. Yang, Jick, S. S., and Jick, H., Statins and the risk of idiopathic venous thromboembolism, Br J Clin Pharmacol, vol. 53, pp. 101-5, 2002.
H. Jick, Zornberg, G. L., Jick, S. S., Seshadri, S., and Drachman, D. A., Statins and the risk of dementia, Lancet, vol. 356, pp. 1627-31, 2000.
K. Tascilar, Dell'Aniello, S., Hudson, M., and Suissa, S., Statins and Risk of Rheumatoid Arthritis: A Nested Case-Control Study, Arthritis Rheumatol, vol. 68, pp. 2603-2611, 2016.
M. C. Bradley, Hughes, C. M., Cantwell, M. M., and Murray, L. J., Statins and pancreatic cancer risk: a nested case-control study, Cancer Causes Control, vol. 21, pp. 2093-100, 2010.
S. S. Jick and Bradbury, B. D., Statins and newly diagnosed diabetes, Br J Clin Pharmacol, vol. 58, pp. 303-9, 2004.
G. J. Lefeber, Koek, H. L., Souverein, P. C., Bouvy, M. L., de Boer, A., and Knol, W., Statins After Myocardial Infarction in the Oldest: A Cohort Study in the Clinical Practice Research Datalink Database, J Am Geriatr Soc, 2019.
L. Alexandre, Clark, A. B., Bhutta, H. Y., Holt, S., Lewis, M. P., and Hart, A. R., Statin use is associated with reduced risk of histologic subtypes of esophageal cancer: a nested case-control analysis, Gastroenterology, vol. 146, pp. 661-8, 2014.
K. Chidwick, Strongman, H., Matthews, A., Stanway, S., Lyon, A. R., Smeeth, L., and Bhaskaran, K., Statin use in cancer survivors versus the general population: cohort study using primary care data from the UK clinical practice research datalink, BMC Cancer, vol. 18, p. 1018, 2018.
J. A. Kaye, Meier, C. R., Walker, A. M., and Jick, H., Statin use, hyperlipidaemia, and the risk of breast cancer, Br J Cancer, vol. 86, pp. 1436-9, 2002.
A. D. Spence, Busby, J., Hughes, C. M., Johnston, B. T., Coleman, H. G., and Cardwell, C. R., Statin use and survival in patients with gastric cancer in two independent population-based cohorts, Pharmacoepidemiol Drug Saf, 2018.
C. R. Cardwell, U. Menamin, M., Hughes, C. M., and Murray, L. J., Statin use and survival from lung cancer: a population-based cohort study, Cancer Epidemiol Biomarkers Prev, vol. 24, pp. 833-41, 2015.
K. A. McGlynn, Hagberg, K., Chen, J., Graubard, B. I., London, W. T., Jick, S., and Sahasrabuddhe, V. V., Statin use and risk of primary liver cancer in the Clinical Practice Research Datalink, J Natl Cancer Inst, vol. 107, 2015.
M. Bodmer, Brauchli, Y. B., Krahenbuhl, S., Jick, S. S., and Meier, C. R., Statin use and risk of gallstone disease followed by cholecystectomy, Jama, vol. 302, pp. 2001-7, 2009.
Y. B. Brauchli, Jick, S. S., and Meier, C. R., Statin use and risk of first-time psoriasis diagnosis, J Am Acad Dermatol, vol. 65, pp. 77-83, 2011.
Z. Liu, Alsaggaf, R., McGlynn, K. A., Anderson, L. A., Tsai, H. T., Zhu, B., Zhu, Y., Mbulaiteye, S. M., Gadalla, S. M., and Koshiol, J., Statin use and reduced risk of biliary tract cancers in the UK Clinical Practice Research Datalink, Gut, 2018.
U. T. Kadam, Blagojevic, M., and Belcher, J., Statin use and clinical osteoarthritis in the general population: a longitudinal study, J Gen Intern Med, vol. 28, pp. 943-9, 2013.
J. A. Kaye and Jick, H., Statin use and cancer risk in the General Practice Research Database, Br J Cancer, vol. 90, pp. 635-7, 2004.
C. R. Cardwell, Hicks, B. M., Hughes, C., and Murray, L. J., Statin use after diagnosis of breast cancer and survival: a population-based cohort study, Epidemiology, vol. 26, pp. 68-78, 2015.
C. R. Cardwell, Hicks, B. M., Hughes, C., and Murray, L. J., Statin use after colorectal cancer diagnosis and survival: a population-based cohort study, J Clin Oncol, vol. 32, pp. 3177-83, 2014.
E. M. van de Garde, Hak, E., Souverein, P. C., Hoes, A. W., van den Bosch, J. M., and Leufkens, H. G., Statin treatment and reduced risk of pneumonia in patients with diabetes, Thorax, vol. 61, pp. 957-61, 2006.
J. Y. Shin, Eberg, M., Ernst, P., and Filion, K. B., Statin potency and the risk of hospitalization for community-acquired pneumonia, Br J Clin Pharmacol, vol. 83, pp. 1319-1327, 2017.
M. Molokhia, McKeigue, P., Curcin, V., and Majeed, A., Statin induced myopathy and myalgia: time trend analysis and comparison of risk associated with statin class from 1991-2006, PLoS One, vol. 3, p. e2522, 2008.
O. A. Oshagbemi, Burden, A. M., Braeken, D. C. W., Henskens, Y., Wouters, E. F. M., Driessen, J. H. M., van der Zee, A. H. Maitlan, de Vries, F., and Franssen, F. M. E., Stability of Blood Eosinophils in Patients with Chronic Obstructive Pulmonary Disease and in Control Subjects, and the Impact of Sex, Age, Smoking, and Baseline Counts, Am J Respir Crit Care Med, vol. 195, pp. 1402-1404, 2017.
S. H. Landis, Suruki, R., Hilton, E., Compton, C., and Galwey, N. W., Stability of Blood Eosinophil Count in Patients with COPD in the UK Clinical Practice Research Datalink, Copd, vol. 14, pp. 382-388, 2017.
I. S. Mackenzie, Morant, S. V., Wei, L., Thompson, A. M., and MacDonald, T. M., Spironolactone use and risk of incident cancers: a retrospective, matched cohort study, Br J Clin Pharmacol, vol. 83, pp. 653-663, 2017.
I. S. Mackenzie, MacDonald, T. M., Thompson, A., Morant, S., and Wei, L., Spironolactone and risk of incident breast cancer in women older than 55 years: retrospective, matched cohort study, Bmj, vol. 345, p. e4447, 2012.
D. C. Lloyd, Harris, C. M., and Roberts, D. J., Specific therapeutic group age-sex related prescribing units (STAR-PUs): weightings for analysing general practices' prescribing in England, Bmj, vol. 311, pp. 991-4, 1995.
E. Kontopantelis, Stevens, R. J., Helms, P. J., Edwards, D., Doran, T., and Ashcroft, D. M., Spatial distribution of clinical computer systems in primary care in England in 2016 and implications for primary care electronic medical record databases: a cross-sectional population study, BMJ Open, vol. 8, p. e020738, 2018.
C. Fairhurst, Martin, F., Watt, I., Doran, T., Bland, M., and Brackenbury, W. J., Sodium channel-inhibiting drugs and cancer survival: protocol for a cohort study using the CPRD primary care database, BMJ Open, vol. 6, p. e011661, 2016.
R. P. Cornish, Boyd, A., Van Staa, T., Salisbury, C., and Macleod, J., Socio-economic position and childhood multimorbidity: a study using linkage between the Avon Longitudinal Study of Parents and Children and the General Practice Research Database, Int J Equity Health, vol. 12, p. 66, 2013.
M. S. Chan, van den Hout, A., Pujades-Rodriguez, M., Jones, M. M., Matthews, F. E., Jagger, C., Raine, R., and Bajekal, M., Socio-economic inequalities in life expectancy of older adults with and without multimorbidity: a record linkage study of 1.1 million people in England, Int J Epidemiol, 2019.
M. Weldegiorgis, Smith, M., Herrington, W. G., Bankhead, C., and Woodward, M., Socioeconomic disadvantage and the risk of advanced chronic kidney disease: results from a cohort study with 1.4 million participants, Nephrology Dialysis Transplantation, 2019.
M. Rafiq, Hayward, A., Warren-Gash, C., Denaxas, S., Gonzalez-Izquierdo, A., Lyratzopoulos, G., and Thomas, S., Socioeconomic deprivation and regional variation in Hodgkin's lymphoma incidence in the UK: a population-based cohort study of 10 million individuals, BMJ Open, vol. 9, p. e029228, 2019.
M. Gulliford, Charlton, J., Bhattarai, N., and Rudisill, C., Social and material deprivation and the cost-effectiveness of an intervention to promote physical activity: cohort study and Markov model, J Public Health (Oxf), vol. 36, pp. 674-83, 2014.
R. M. Joseph, Movahedi, M., Dixon, W. G., and Symmons, D. P., Smoking-Related Mortality in Patients With Early Rheumatoid Arthritis: A Retrospective Cohort Study Using the Clinical Practice Research Datalink, Arthritis Care Res (Hoboken), vol. 68, pp. 1598-1606, 2016.
[Page last reviewed 6 December 2019]