Research using CPRD data has informed drug safety guidance and clinical practice and resulted in over 2,700 peer-reviewed publications. The CPRD bibliography is updated on a monthly basis (last updated 6 April 2021) and papers are listed below and in the PDF below.

If you have published papers using CPRD data which are not included in this list, please contact us at so that we can update the bibliography.


 (PDF, 5MB, 226 pages) 

This work uses data provided by patients and collected by the NHS as part of their care and support. CPRD encourages researchers to use this citation in all publications using CPRD data. Find out more about acknowledging the use of patient data at the Understanding Patient Data website



Export 26 results:
Author Title Type [ Year(Asc)]
Filters: Author is Bottle, A.  [Clear All Filters]
C. S. Arhi, Burns, E. M., Bottle, A., Bouras, G., Aylin, P., Ziprin, P., and Darzi, A., Delays in referral from primary care worsen survival for patients with colorectal cancer: a retrospective cohort study, Br J Gen Pract, vol. 70, pp. e463-e471, 2020.
J. Blackwell, Saxena, S., Petersen, I., Hotopf, M., Creese, H., Bottle, A., Alexakis, C., and Pollok, R. C., Depression in individuals who subsequently develop inflammatory bowel disease: a population-based nested case-control study, Gut, 2020.
R. Ma, Cecil, E., Bottle, A., French, R., and Saxena, S., Impact of a pay-for-performance scheme for long-acting reversible contraceptive (LARC) advice on contraceptive uptake and abortion in British primary care: An interrupted time series study, PLoS Med, vol. 17, p. e1003333, 2020.
J. Blackwell, Saxena, S., Jayasooriya, N., Bottle, A., Petersen, I., Hotopf, M., Alexakis, C., and Pollok, R. C., Prevalence and duration of gastrointestinal symptoms before diagnosis of Inflammatory Bowel Disease and predictors of timely specialist review: a population-based study, J Crohns Colitis, 2020.
J. Blackwell, Saxena, S., Jayasooriya, N., Petersen, I., Hotopf, M., Creese, H., Bottle, A., and Pollok, R. C. G., Stoma formation in Crohn's Disease and the likelihood of antidepressant use: a population-based cohort study, Clin Gastroenterol Hepatol, 2020.
E. L. Axson, Sundaram, V., Bloom, C. I., Bottle, A., Cowie, M. R., and Quint, J. K., Temporal Trends in the Incidence of Heart Failure among Patients with COPD and Its Association with Mortality, Ann Am Thorac Soc, 2020.
J. Ruzangi, Blair, M., Cecil, E., Greenfield, G., Bottle, A., Hargreaves, D. S., and Saxena, S., Trends in healthcare use in children aged less than 15 years: a population-based cohort study in England from 2007 to 2017, BMJ Open, vol. 10, p. e033761, 2020.
B. Hayhoe, Kim, D., Aylin, P. P., Majeed, F. A., Cowie, M. R., and Bottle, A., Adherence to guidelines in management of symptoms suggestive of heart failure in primary care, Heart, 2018.
C. S. Arhi, Bottle, A., Burns, E. M., Clarke, J. M., Aylin, P., Ziprin, P., and Darzi, A., Comparison of cancer diagnosis recording between the Clinical Practice Research Datalink, Cancer Registry and Hospital Episodes Statistics, Cancer Epidemiol, vol. 57, pp. 148-157, 2018.
E. Cecil, Bottle, A., Ma, R., Hargreaves, D. S., Wolfe, I., ,, and Saxena, S., Impact of preventive primary care on children's unplanned hospital admissions: a population-based birth cohort study of UK children 2000-2013, BMC Med, vol. 16, p. 151, 2018.
A. Rao, Kim, D., Darzi, A., Majeed, A., Aylin, P., and Bottle, A., Long-term trends of use of health service among heart failure patients, Eur Heart J Qual Care Clin Outcomes, vol. 4, pp. 220-231, 2018.
A. Bottle, Kim, D., Aylin, P. P., Majeed, F. A., Cowie, M. R., and Hayhoe, B., Real-world presentation with heart failure in primary care: do patients selected to follow diagnostic and management guidelines have better outcomes?, Open Heart, vol. 5, p. e000935, 2018.
A. Bottle, Kim, D., Aylin, P., Cowie, M. R., Majeed, A., and Hayhoe, B., Routes to diagnosis of heart failure: observational study using linked data in England, Heart, vol. 104, pp. 600-605, 2018.
[Page last reviewed 6 April 2021]