Research using CPRD data has informed drug safety guidance and clinical practice and resulted in over 2,300 peer-reviewed publications.

The CPRD bibliography is updated on a monthly basis (last updated 4 December 2019) and papers are listed below and in the PDF below.

If you have published papers using CPRD data which are not included in this list, please contact us at so that we can update the bibliography.


(PDF, 3MB, 193 pages)


Export 2384 results:
Author Title [ Type(Asc)] Year
Journal Article
J. Castellsague, Garcia-Rodriguez, L. A., Duque, A., and Perez, S., Risk of serious skin disorders among users of oral antifungals: a population-based study, BMC Dermatol, vol. 2, p. 14, 2002.
T. Lancaster, Swart, A. M., and Jick, H., Risk of serious haematological toxicity with use of chloramphenicol eye drops in a British general practice database, Bmj, vol. 316, p. 667, 1998.
R. T. Webb, Kontopantelis, E., Doran, T., Qin, P., Creed, F., and Kapur, N., Risk of self-harm in physically ill patients in UK primary care, J Psychosom Res, vol. 73, pp. 92-7, 2012.
H. Jick, Derby, L. E., Vasilakis, C., and Fife, D., The risk of seizures associated with tramadol, Pharmacotherapy, vol. 18, pp. 607-11, 1998.
M. Bloechliger, Ceschi, A., Ruegg, S., Kupferschmidt, H., Kraehenbuehl, S., Jick, S. S., Meier, C. R., and Bodmer, M., Risk of Seizures Associated with Antidepressant Use in Patients with Depressive Disorder: Follow-up Study with a Nested Case-Control Analysis Using the Clinical Practice Research Datalink, Drug Saf, vol. 39, pp. 307-21, 2016.
J. West, Logan, R. F., Hubbard, R. B., and Card, T. R., Risk of schizophrenia in people with coeliac disease, ulcerative colitis and Crohn's disease: a general population-based study, Aliment Pharmacol Ther, vol. 23, pp. 71-4, 2006.
C. Martinez, Katholing, A., Folkerts, K., and Cohen, A. T., Risk of recurrent venous thromboembolism after discontinuation of vitamin K antagonist treatment: a nested case-control study, J Thromb Haemost, vol. 14, pp. 1374-83, 2016.
R. Alikhan, Lefevre, C., Menown, I., Lister, S., Bird, A., You, M., Evans, D., and Sammon, C., Risk of Recurrent Bleeding Events in Nonvalvular Atrial Fibrillation Treated with Vitamin K Antagonists: A Clinical Practice Research Datalink Study, TH Open, vol. 3, pp. e316-e324, 2019.
G. Bouras, Burns, E. M., Howell, A. M., Bottle, A., Athanasiou, T., and Darzi, A., Risk of Post-Discharge Venous Thromboembolism and Associated Mortality in General Surgery: A Population-Based Cohort Study Using Linked Hospital and Primary Care Data in England, PLoS One, vol. 10, p. e0145759, 2015.
S. Stapley, Peters, T. J., Neal, R. D., Rose, P. W., Walter, F. M., and Hamilton, W., The risk of pancreatic cancer in symptomatic patients in primary care: a large case-control study using electronic records, Br J Cancer, vol. 106, pp. 1940-4, 2012.
A. Arana, Johannes, C. B., McQuay, L. J., Varas-Lorenzo, C., Fife, D., and Rothman, K. J., Risk of Out-of-Hospital Sudden Cardiac Death in Users of Domperidone, Proton Pump Inhibitors, or Metoclopramide: A Population-Based Nested Case-Control Study, Drug Saf, vol. 38, pp. 1187-99, 2015.
C. Huerta, Rodriguez, L. A. Garcia, Moller, C. S., and Arellano, F. M., The risk of obstructive airways disease in a glaucoma population, Pharmacoepidemiol Drug Saf, vol. 10, pp. 157-63, 2001.
C. Becker, Brobert, G. P., Almqvist, P. M., Johansson, S., Jick, S. S., and Meier, C. R., The risk of newly diagnosed asthma in migraineurs with or without previous triptan prescriptions, Headache, vol. 48, pp. 606-10, 2008.
D. Bornand, Toovey, S., Jick, S. S., and Meier, C. R., The risk of new onset depression in association with influenza–A population-based observational study, Brain Behav Immun, vol. 53, pp. 131-137, 2016.
C. Willame, Rosillon, D., Zima, J., Angelo, M. G., Stuurman, A. L., Vroling, H., Boggon, R., Bunge, E. M., Pladevall-Vila, M., and Baril, L., Risk of new onset autoimmune disease in 9- to 25-year-old women exposed to human papillomavirus-16/18 AS04-adjuvanted vaccine in the United Kingdom, Hum Vaccin Immunother, vol. 12, pp. 2862-2871, 2016.
J. M. Gelfand, Neimann, A. L., Shin, D. B., Wang, X., Margolis, D. J., and Troxel, A. B., Risk of myocardial infarction in patients with psoriasis, Jama, vol. 296, pp. 1735-41, 2006.
L. M. Stolk, de Vries, F., Ebbelaar, C., de Boer, A., Schalekamp, T., Souverein, P., A. Cate-Hoek, T., and Burden, A. M., Risk of myocardial infarction in patients with atrial fibrillation using vitamin K antagonists, aspirin or direct acting oral anticoagulants, Br J Clin Pharmacol, vol. 83, pp. 1835-1843, 2017.
H. E. Mulnier, Seaman, H. E., Raleigh, V. S., Soedamah-Muthu, S. S., Colhoun, H. M., Lawrenson, R. A., and de Vries, C. S., Risk of myocardial infarction in men and women with type 2 diabetes in the UK: a cohort study using the General Practice Research Database, Diabetologia, vol. 51, pp. 1639-45, 2008.
H. Jick, Derby, L. E., Gurewich, V., and Vasilakis, C., The risk of myocardial infarction associated with antihypertensive drug treatment in persons with uncomplicated essential hypertension, Pharmacotherapy, vol. 16, pp. 321-6, 1996.
L. Smeeth, Thomas, S. L., Hall, A. J., Hubbard, R., Farrington, P., and Vallance, P., Risk of myocardial infarction and stroke after acute infection or vaccination, N Engl J Med, vol. 351, pp. 2611-8, 2004.
C. Huerta, Johansson, S., Wallander, M. A., and Rodriguez, L. A., Risk of myocardial infarction and overall mortality in survivors of venous thromboembolism, Thromb J, vol. 6, p. 10, 2008.
M. E. Jones, Campbell, G., Patel, D., Brunner, E., Shatapathy, C. C., Murray-Thomas, T., van Staa, T. P., and Motsko, S., Risk of Mortality (including Sudden Cardiac Death) and Major Cardiovascular Events in Users of Olanzapine and Other Antipsychotics: A Study with the General Practice Research Database, Cardiovasc Psychiatry Neurol, vol. 2013, p. 647476, 2013.
J. M. Gelfand, Troxel, A. B., Lewis, J. D., Kurd, S. K., Shin, D. B., Wang, X., Margolis, D. J., and Strom, B. L., The risk of mortality in patients with psoriasis: results from a population-based study, Arch Dermatol, vol. 143, pp. 1493-9, 2007.
A. Ruigomez, Johansson, S., Wallander, M. A., and Rodriguez, L. A. Garcia, Risk of mortality in a cohort of patients newly diagnosed with chronic atrial fibrillation, BMC Cardiovasc Disord, vol. 2, p. 5, 2002.
E. Williamson, Denaxas, S., Morris, S., Clarke, C. S., Thomas, M., Evans, H., Direk, K., Gonzalez-Izquierdo, A., Little, P., Lund, V., Blackshaw, H., Schilder, A., Philpott, C., Hopkins, C., and Carpenter, J., Risk of mortality and cardiovascular events following macrolide prescription in chronic rhinosinusitis patients: a cohort study using linked primary care electronic health records, Rhinology, 2019.
E. M. Gieling, van den Ham, H. A., van Onzenoort, H., Bos, J., Kramers, C., de Boer, A., de Vries, F., and Burden, A. M., Risk of major bleeding and stroke associated with the use of vitamin K antagonists, nonvitamin K antagonist oral anticoagulants and aspirin in patients with atrial fibrillation: a cohort study, Br J Clin Pharmacol, vol. 83, pp. 1844-1859, 2017.
D. Gibson-Smith, Klop, C., Elders, P. J., Welsing, P. M., van Schoor, N., Leufkens, H. G., Harvey, N. C., van Staa, T. P., and de Vries, F., The risk of major and any (non-hip) fragility fracture after hip fracture in the United Kingdom: 2000-2010, Osteoporos Int, vol. 25, pp. 2555-63, 2014.
J. M. Gelfand, Shin, D. B., Neimann, A. L., Wang, X., Margolis, D. J., and Troxel, A. B., The risk of lymphoma in patients with psoriasis, J Invest Dermatol, vol. 126, pp. 2194-201, 2006.
H. E. Seaman, de Vries, C. S., and Farmer, R. D., The risk of liver disorders in women prescribed cyproterone acetate in combination with ethinyloestradiol (Dianette): a nested case-control study using the GPRD, Pharmacoepidemiol Drug Saf, vol. 12, pp. 541-50, 2003.
H. E. Seaman, Lawrenson, R. A., Williams, T. J., MacRae, K. D., and Farmer, R. D., The risk of liver damage associated with minocycline: a comparative study, J Clin Pharmacol, vol. 41, pp. 852-60, 2001.
W. L. Eppenga, Lalmohamed, A., Geerts, A. F., Derijks, H. J., Wensing, M., Egberts, A., De Smet, P. A., and de Vries, F., Risk of lactic acidosis or elevated lactate concentrations in metformin users with renal impairment: a population-based cohort study, Diabetes Care, vol. 37, pp. 2218-24, 2014.
F. Andersohn, Waring, M., and Garbe, E., Risk of ischemic stroke in patients with Crohn's disease: a population-based nested case-control study, Inflamm Bowel Dis, vol. 16, pp. 1387-92, 2010.
H. Close, Mason, J. M., Wilson, D. W., Hungin, A. P., Jones, R., and Rubin, G., Risk of Ischaemic Heart Disease in Patients with Inflammatory Bowel Disease: Cohort Study Using the General Practice Research Database, PLoS One, vol. 10, p. e0139745, 2015.
C. Huerta, Rodriguez, L. A. Garcia, Wallander, M. A., and Johansson, S., Risk of irritable bowel syndrome among asthma patients, Pharmacoepidemiol Drug Saf, vol. 11, pp. 31-5, 2002.
B. Spaetgens, de Vries, F., Driessen, J. H. M., Leufkens, H. G., Souverein, P. C., Boonen, A., van der Meer, J. W. M., and Joosten, L. A. B., Risk of infections in patients with gout: a population-based cohort study, Sci Rep, vol. 7, p. 1429, 2017.
I. M. Carey, Critchley, J. A., DeWilde, S., Harris, T., Hosking, F. J., and Cook, D. G., Risk of Infection in Type 1 and Type 2 Diabetes Compared With the General Population: A Matched Cohort Study, Diabetes Care, vol. 41, pp. 513-521, 2018.
P. Imfeld, Bodmer, M., Schuerch, M., Jick, S. S., and Meier, C. R., Risk of incident stroke in patients with Alzheimer disease or vascular dementia, Neurology, vol. 81, pp. 910-9, 2013.
T. Burkard, Hugle, T., Layton, J. B., Glynn, R. J., Bloechliger, M., Frey, N., Jick, S. S., Meier, C. R., and Spoendlin, J., Risk of Incident Osteoarthritis of the Hand in Statin Initiators: A Sequential Cohort Study, Arthritis Care Res (Hoboken), vol. 70, pp. 1795-1805, 2018.
M. Movahedi, Beauchamp, M. E., Abrahamowicz, M., Ray, D. W., Michaud, K., Pedro, S., and Dixon, W. G., Risk of Incident Diabetes Mellitus Associated With the Dosage and Duration of Oral Glucocorticoid Therapy in Patients With Rheumatoid Arthritis, Arthritis Rheumatol, vol. 68, pp. 1089-98, 2016.
C. Becker, Brobert, G. P., Johansson, S., Jick, S. S., and Meier, C. R., Risk of incident depression in patients with Parkinson disease in the UK, Eur J Neurol, vol. 18, pp. 448-53, 2011.
K. W. Hagberg, Divan, H. A., Nickel, J. C., and Jick, S. S., Risk of Incident Antidepressant-Treated Depression Associated with Use of 5alpha-Reductase Inhibitors Compared with Use of alpha-Blockers in Men with Benign Prostatic Hyperplasia: A Population-Based Study Using the Clinical Practice Research Datalink, Pharmacotherapy, vol. 37, pp. 517-527, 2017.
C. Vasilakis, Jick, H., and M. Melero-Montes, delMar, Risk of idiopathic venous thromboembolism in users of progestagens alone, Lancet, vol. 354, pp. 1610-1, 1999.
S. S. Jick, Myers, M. W., and Jick, H., Risk of idiopathic cerebral haemorrhage in women on oral contraceptives with differing progestagen components, Lancet, vol. 354, pp. 302-3, 1999.
H. Jick, Jick, S. S., Gurewich, V., Myers, M. W., and Vasilakis, C., Risk of idiopathic cardiovascular death and nonfatal venous thromboembolism in women using oral contraceptives with differing progestagen components, Lancet, vol. 346, pp. 1589-93, 1995.
J. van Dalem, Brouwers, M. C., Stehouwer, C. D., Krings, A., Leufkens, H. G., Driessen, J. H., de Vries, F., and Burden, A. M., Risk of hypoglycaemia in users of sulphonylureas compared with metformin in relation to renal function and sulphonylurea metabolite group: population based cohort study, Bmj, vol. 354, p. i3625, 2016.
L. A. Garcia Rodriguez, Cattaruzzi, C., Troncon, M. G., and Agostinis, L., Risk of hospitalization for upper gastrointestinal tract bleeding associated with ketorolac, other nonsteroidal anti-inflammatory drugs, calcium antagonists, and other antihypertensive drugs, Arch Intern Med, vol. 158, pp. 33-9, 1998.
G. W. Hugenholtz, Heerdink, E. R., van Staa, T. P., Nolen, W. A., and Egberts, A. C., Risk of hip/femur fractures in patients using antipsychotics, Bone, vol. 37, pp. 864-70, 2005.
L. Howard, Kirkwood, G., and Leese, M., Risk of hip fracture in patients with a history of schizophrenia, Br J Psychiatry, vol. 190, pp. 129-34, 2007.
A. L. Smitten, Choi, H. K., Hochberg, M. C., Suissa, S., Simon, T. A., Testa, M. A., and Chan, K. A., The risk of herpes zoster in patients with rheumatoid arthritis in the United States and the United Kingdom, Arthritis Rheum, vol. 57, pp. 1431-8, 2007.
P. Ernst, Dell'Aniello, S., Mikaeloff, Y., and Suissa, S., Risk of herpes zoster in patients prescribed inhaled corticosteroids: a cohort study, BMC Pulm Med, vol. 11, p. 59, 2011.
[Page last reviewed 6 December 2019]