Research using CPRD data has informed drug safety guidance and clinical practice and resulted in over 2,800 peer-reviewed publications. The CPRD bibliography is updated on a monthly basis (last updated 4 June 2021) and papers are listed below and in the PDF below.

If you have published papers using CPRD data which are not included in this list, please contact us at so that we can update the bibliography.


 (PDF, 5MB, 229 pages) 

This work uses data provided by patients and collected by the NHS as part of their care and support. CPRD encourages researchers to use this citation in all publications using CPRD data. Find out more about acknowledging the use of patient data at the Understanding Patient Data website



Export 2809 results:
Author [ Title(Desc)] Type Year
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 
R. Flynn, Hedenmalm, K., Murray-Thomas, T., Pacurariu, A., Arlett, P., Shepherd, H., Myles, P., and Kurz, X., Ability of primary care health databases to assess medicinal products discussed by the European Union Pharmacovigilance Risk Assessment Committee, Clin Pharmacol Ther, 2020.
B. L. Strom, Schinnar, R., Apter, A. J., Margolis, D. J., Lautenbach, E., Hennessy, S., Bilker, W. B., and Pettitt, D., Absence of cross-reactivity between sulfonamide antibiotics and sulfonamide nonantibiotics, N Engl J Med, vol. 349, pp. 1628-35, 2003.
Y. C. Chen, Wu, J. C., Haschler, I., Majeed, A., Chen, T. J., and Wetter, T., Academic impact of a public electronic health database: bibliometric analysis of studies using the general practice research database, PLoS One, vol. 6, p. e21404, 2011.
H. R. Whittaker, Bloom, C., Morgan, A., Jarvis, D., Kiddle, S. J., and Quint, J. K., Accelerated FEV(1) decline and risk of cardiovascular disease and mortality in a primary care population of COPD patients, Eur Respir J, 2020.
H. P. Booth, Prevost, A. T., and Gulliford, M. C., Access to weight reduction interventions for overweight and obese patients in UK primary care: population-based cohort study, BMJ Open, vol. 5, p. e006642, 2015.
S. M. Grandi, Filion, K. B., Hutcheon, J. A., Rosella, L. C., and Platt, R. W., Accounting for Repeat Pregnancies in Risk Prediction Models, Epidemiology, 2021.
R. McCarney, Fisher, P., and van Haselen, R., Accruing large numbers of patients in primary care trials by retrospective recruitment methods, Complement Ther Med, vol. 10, pp. 63-8, 2002.
A. M. Gallagher, Dedman, D., Padmanabhan, S., Leufkens, H. G. M., and de Vries, F., The accuracy of date of death recording in the Clinical Practice Research Datalink GOLD database in England compared with the Office for National Statistics death registrations, Pharmacoepidemiol Drug Saf, 2019.
I. Nazareth, King, M., Haines, A., Rangel, L., and Myers, S., Accuracy of diagnosis of psychosis on general practice computer system, Bmj, vol. 307, pp. 32-4, 1993.
C. Becker, Jick, S. S., and Meier, C. R., ACE inhibitor use and risk of cataract: a case-control analysis, Br J Ophthalmol, 2019.
J. A. Kaye, Myers, M. W., and Jick, H., Acetaminophen and the risk of renal and bladder cancer in the general practice research database, Epidemiology, vol. 12, pp. 690-4, 2001.
J. Dawson, Fulton, R., McInnes, G. T., Morton, R., Morrison, D., Padmanabhan, S., Hewitt, J., Meredith, P., Muir, S., Dominiczak, A. F., and Walters, M. R., Acetaminophen use and change in blood pressure in a hypertensive population, J Hypertens, vol. 31, pp. 1485-90; discussion 1490, 2013.
I. Tamimi, Nicolau, B., Eimar, H., S. Madathil, A., Kezouh, A., Karp, I., and Tamimi, F., Acetylcholinesterase inhibitors and the risk of osteoporotic fractures: nested case-control study, Osteoporos Int, vol. 29, pp. 849-857, 2018.
J. Spoendlin, Meier, C., Jick, S. S., and Meier, C. R., Achilles or biceps tendon rupture in women and men with type 2 diabetes: A population-based case-control study, J Diabetes Complications, vol. 30, pp. 903-9, 2016.
T. Khan, Alvand, A., Prieto-Alhambra, D., Culliford, D. J., Judge, A., Jackson, W. F., Scammell, B. E., Arden, N. K., and Price, A. J., ACL and meniscal injuries increase the risk of primary total knee replacement for osteoarthritis: a matched case-control study using the Clinical Practice Research Datalink (CPRD), Br J Sports Med, 2018.
F. J. de Abajo, Montero, D., Madurga, M., and Rodriguez, L. A. Garcia, Acute and clinically relevant drug-induced liver injury: a population based case-control study, Br J Clin Pharmacol, vol. 58, pp. 71-80, 2004.
L. A. Garcia Rodriguez, Ruigomez, A., and Panes, J., Acute gastroenteritis is followed by an increased risk of inflammatory bowel disease, Gastroenterology, vol. 130, pp. 1588-94, 2006.
K. E. Mansfield, Douglas, I. J., Nitsch, D., Thomas, S. L., Smeeth, L., and Tomlinson, L. A., Acute kidney injury and infections in patients taking antihypertensive drugs: a self-controlled case series analysis, Clin Epidemiol, vol. 10, pp. 187-202, 2018.
M. F. Barakat, McDonald, H. I., Collier, T. J., Smeeth, L., Nitsch, D., and Quint, J. K., Acute kidney injury in stable COPD and at exacerbation, Int J Chron Obstruct Pulmon Dis, vol. 10, pp. 2067-77, 2015.
L. A. Garcia Rodriguez, Williams, R., Derby, L. E., Dean, A. D., and Jick, H., Acute liver injury associated with nonsteroidal anti-inflammatory drugs and the role of risk factors, Arch Intern Med, vol. 154, pp. 311-6, 1994.
C. Minassian, Thomas, S. L., Williams, D. J., Campbell, O., and Smeeth, L., Acute maternal infection and risk of pre-eclampsia: a population-based case-control study, PLoS One, vol. 8, p. e73047, 2013.
C. R. Meier, Jick, S. S., Derby, L. E., Vasilakis, C., and Jick, H., Acute respiratory-tract infections and risk of first-time acute myocardial infarction, Lancet, vol. 351, pp. 1467-71, 1998.
N. F. Khan, Perera, R., Harper, S., and Rose, P. W., Adaptation and validation of the Charlson Index for Read/OXMIS coded databases, BMC Fam Pract, vol. 11, p. 1, 2010.
G. Simoneau, Moodie, E. E. M., Azoulay, L., and Platt, R. W., Adaptive Treatment Strategies with Survival Outcomes: An Application to the Treatment of Type 2 Diabetes using a Large Observational Database, Am J Epidemiol, 2020.
J. Watson, Salisbury, C., Whiting, P., Banks, J., Pyne, Y., and Hamilton, W., Added value and cascade effects of inflammatory marker tests in UK primary care: a cohort study from the Clinical Practice Research Datalink, Br J Gen Pract, vol. 69, pp. e470-e478, 2019.
K. Kostikas, Rhee, C. K., Hurst, J. R., Agostoni, P., Cao, H., Fogel, R., Jones, R., Kocks, J. W. H., Mezzi, K., S. Ming, W. Yau, Ryan, R., and Price, D. B., Adequacy of Therapy for People with Both COPD and Heart Failure in the UK: Historical Cohort Study, Pragmat Obs Res, vol. 11, pp. 55-66, 2020.
A. J. Hire, Ashcroft, D. M., Springate, D. A., and Steinke, D. T., ADHD in the United Kingdom: Regional and Socioeconomic Variations in Incidence Rates Amongst Children and Adolescents (2004-2013), J Atten Disord, vol. 22, pp. 134-142, 2018.
M. Schmidt, Mansfield, K. E., Bhaskaran, K., Nitsch, D., Sorensen, H. T., Smeeth, L., and Tomlinson, L. A., Adherence to guidelines for creatinine and potassium monitoring and discontinuation following renin-angiotensin system blockade: a UK general practice-based cohort study, BMJ Open, vol. 7, p. e012818, 2017.
B. Hayhoe, Kim, D., Aylin, P. P., Majeed, F. A., Cowie, M. R., and Bottle, A., Adherence to guidelines in management of symptoms suggestive of heart failure in primary care, Heart, 2018.
K. D. Johnson, Lu, X., and Zhang, D., Adherence to hepatitis A and hepatitis B multi-dose vaccination schedules among adults in the United Kingdom: a retrospective cohort study, BMC Public Health, vol. 19, p. 404, 2019.
K. Jameson, D'Oca, K., Murray-Thomas, T., O'Regan, C., and Leigh, P., Adherence to Nice Guidance For Initiating Glp-1 Mimetics Among Patients With Type 2 Diabetes In Primary Care In England And Wales - An Evaluation Using The Clinical Practice Research Datalink (Cprd), Value Health, vol. 17, p. A362, 2014.
K. Jameson, D'Oca, K., Leigh, P., and Murray-Thomas, T., Adherence to NICE guidance on glucagon-like peptide-1 receptor agonists among patients with type 2 diabetes mellitus: an evaluation using the Clinical Practice Research Datalink, Curr Med Res Opin, vol. 32, pp. 49-60, 2016.
A. J. Farmer, Rodgers, L. R., Lonergan, M., Shields, B., Weedon, M. N., Donnelly, L., Holman, R. R., Pearson, E. R., and Hattersley, A. T., Adherence to Oral Glucose-Lowering Therapies and Associations With 1-Year HbA1c: A Retrospective Cohort Analysis in a Large Primary Care Database, Diabetes Care, vol. 39, pp. 258-263, 2016.
M. J. Crowther, Lambert, P. C., and Abrams, K. R., Adjusting for measurement error in baseline prognostic biomarkers included in a time-to-event analysis: a joint modelling approach, BMC Med Res Methodol, vol. 13, p. 146, 2013.
B. Numbere, Fleming, K. M., Walker, A., and Card, T. R., Adrenergic blockers and the risk for common solid cancers: a case-control study, Eur J Cancer Prev, vol. 26, pp. 86-93, 2017.
R. Hubbard and Venn, A., Adult height and cryptogenic fibrosing alveolitis: a case-control study using the UK general practice research database, Thorax, vol. 55, pp. 864-6, 2000.
R. L. Tannen, Barnhart, K. T., and Rubin, J. C., Advantages of large medical record database for outcomes research: Insights into post-menopausal hormone therapy, Learn Health Syst, vol. 3, p. e10193, 2019.
K. Richardson, Loke, Y. K., Fox, C., Maidment, I., Howard, R., Steel, N., Arthur, A., Boyd, P. J., Aldus, C., Ballard, C., and Savva, G. M., Adverse effects of Z-drugs for sleep disturbance in people living with dementia: a population-based cohort study, BMC Med, vol. 18, p. 351, 2020.
S. B. Meropol, Chan, K. A., Chen, Z., Finkelstein, J. A., Hennessy, S., Lautenbach, E., Platt, R., Schech, S. D., Shatin, D., and Metlay, J. P., Adverse events associated with prolonged antibiotic use, Pharmacoepidemiol Drug Saf, vol. 17, pp. 523-32, 2008.
M. Bloechliger, Reinau, D., Spoendlin, J., Chang, S. C., Kuhlbusch, K., Heaney, L. G., Jick, S. S., and Meier, C. R., Adverse events profile of oral corticosteroids among asthma patients in the UK: cohort study with a nested case-control analysis, Respir Res, vol. 19, p. 75, 2018.
C. Tsang, Bottle, A., Majeed, A., and Aylin, P., Adverse events recorded in English primary care: observational study using the General Practice Research Database, Br J Gen Pract, vol. 63, pp. e534-42, 2013.
H. Carreira, Williams, R., Muller, M., Harewood, R., and Bhaskaran, K., Adverse mental health outcomes in breast cancer survivors compared to women who did not have cancer: systematic review protocol, Syst Rev, vol. 6, p. 162, 2017.
[Page last reviewed 4 June 2021]