Research using CPRD data has informed drug safety guidance and clinical practice and resulted in over 2,400 peer-reviewed publications. The CPRD bibliography is updated on a monthly basis (last updated 6 April 2020) and papers are listed below and in the PDF below.

If you have published papers using CPRD data which are not included in this list, please contact us at so that we can update the bibliography.


 (PDF, 3MB, 196 pages) 

This work uses data provided by patients and collected by the NHS as part of their care and support. CPRD encourages researchers to use this citation in all publications using CPRD data. Find out more about acknowledging the use of patient data at the Understanding Patient Data website



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Journal Article
M. F. Barakat, McDonald, H. I., Collier, T. J., Smeeth, L., Nitsch, D., and Quint, J. K., Acute kidney injury in stable COPD and at exacerbation, Int J Chron Obstruct Pulmon Dis, vol. 10, pp. 2067-77, 2015.
V. Schneider-Lindner, Quach, C., Hanley, J. A., and Suissa, S., Antibacterial drugs and the risk of community-associated methicillin-resistant Staphylococcus aureus in children, Arch Pediatr Adolesc Med, vol. 165, pp. 1107-14, 2011.
N. Qizilbash, Gregson, J., Johnson, M. E., Pearce, N., Douglas, I., Wing, K., Evans, S. J. W., and Pocock, S. J., BMI and risk of dementia in two million people over two decades: a retrospective cohort study, Lancet Diabetes Endocrinol, vol. 3, pp. 431-436, 2015.
V. Navaratnam, Millett, E. R., Hurst, J. R., Thomas, S. L., Smeeth, L., Hubbard, R. B., Brown, J., and Quint, J. K., Bronchiectasis and the risk of cardiovascular disease: a population-based study, Thorax, vol. 72, pp. 161-166, 2017.
I. Matthews, Duong, M., Parsons, V. L., Nozad, B., Qizilbash, N., Patel, Y., and Guimicheva, B., Burden of disease from shingles and post-herpetic neuralgia in the over 80 year olds in the UK, PLoS One, vol. 15, p. e0229224, 2020.
S. F. Weng, Reps, J., Kai, J., Garibaldi, J. M., and Qureshi, N., Can machine-learning improve cardiovascular risk prediction using routine clinical data?, PLoS One, vol. 12, p. e0174944, 2017.
J. K. Quint, Millett, E. R., Joshi, M., Navaratnam, V., Thomas, S. L., Hurst, J. R., Smeeth, L., and Brown, J. S., Changes in the incidence, prevalence and mortality of bronchiectasis in the UK from 2004 to 2013: a population-based cohort study, Eur Respir J, vol. 47, pp. 186-93, 2016.
A. V. Gayle, Axson, E. L., Bloom, C. I., Navaratnam, V., and Quint, J. K., Changing causes of death for patients with chronic respiratory disease in England, 2005-2015, Thorax, 2019.
A. D. Morgan, Rothnie, K. J., Bhaskaran, K., Smeeth, L., and Quint, J. K., Chronic obstructive pulmonary disease and the risk of 12 cardiovascular diseases: a population-based study using UK primary care data, Thorax, vol. 73, pp. 877-879, 2018.
F. Nissen, Douglas, I. J., Mullerova, H., Pearce, N., Bloom, C. I., Smeeth, L., and Quint, J. K., Clinical profile of predefined asthma phenotypes in a large cohort of UK primary care patients (Clinical Practice Research Datalink), J Asthma Allergy, vol. 12, pp. 7-19, 2019.
M. J. Brodie, Chung, S., Wade, A., Quelen, C., Guiraud-Diawara, A., Francois, C., Verpillat, P., Shen, V., and Isojarvi, J., Clobazam and clonazepam use in epilepsy: Results from a UK database incident user cohort study, Epilepsy Res, vol. 123, pp. 68-74, 2016.
K. J. Rothnie, Smeeth, L., Herrett, E., Pearce, N., Hemingway, H., Wedzicha, J., Timmis, A., and Quint, J. K., Closing the mortality gap after a myocardial infarction in people with and without chronic obstructive pulmonary disease, Heart, vol. 101, pp. 1103-10, 2015.
M. Nowakowska, Zghebi, S. S., Ashcroft, D. M., Buchan, I., Chew-Graham, C., Holt, T., Mallen, C., van Marwijk, H., Peek, N., Perera-Salazar, R., Reeves, D., Rutter, M. K., Weng, S. F., Qureshi, N., Mamas, M. A., and Kontopantelis, E., The comorbidity burden of type 2 diabetes mellitus: patterns, clusters and predictions from a large English primary care cohort, BMC Med, vol. 17, p. 145, 2019.
K. Mansfield, Crellin, E., Denholm, R., Quint, J. K., Smeeth, L., Cook, S., and Herrett, E., Completeness and validity of alcohol recording in general practice within the UK: a cross-sectional study, BMJ Open, vol. 9, p. e031537, 2019.
F. Nissen, Morales, D. R., Mullerova, H., Smeeth, L., Douglas, I. J., and Quint, J. K., Concomitant diagnosis of asthma and COPD: a quantitative study in UK primary care, Br J Gen Pract, vol. 68, pp. e775-e782, 2018.
A. D. Morgan, Herrett, E., De Stavola, B. L., Smeeth, L., and Quint, J. K., COPD disease severity and the risk of venous thromboembolic events: a matched case-control study, Int J Chron Obstruct Pulmon Dis, vol. 11, pp. 899-908, 2016.
C. I. Bloom, Douglas, I., Olney, J., D'Ancona, G., Smeeth, L., and Quint, J. K., Cost saving of switching to equivalent inhalers and its effect on health outcomes, Thorax, 2019.
M. Iwagami, Mansfield, K., Quint, J., Nitsch, D., and Tomlinson, L., Diagnosis of acute kidney injury and its association with in-hospital mortality in patients with infective exacerbations of bronchiectasis: cohort study from a UK nationwide database, BMC Pulm Med, vol. 16, p. 14, 2016.
H. I. McDonald, Thomas, S. L., Millett, E. R. C., Quint, J., and Nitsch, D., Do influenza and pneumococcal vaccines prevent community-acquired respiratory infections among older people with diabetes and does this vary by chronic kidney disease? A cohort study using electronic health records, BMJ Open Diabetes Res Care, vol. 5, p. e000332, 2017.
P. Dhiman, Andersen, S., Vestergaard, P., Masud, T., and Qureshi, N., Does bone mineral density improve the predictive accuracy of fracture risk assessment? A prospective cohort study in Northern Denmark, BMJ Open, vol. 8, p. e018898, 2018.
J. K. Quint, Herrett, E., Bhaskaran, K., Timmis, A., Hemingway, H., Wedzicha, J. A., and Smeeth, L., Effect of beta blockers on mortality after myocardial infarction in adults with COPD: population based cohort study of UK electronic healthcare records, Bmj, vol. 347, p. f6650, 2013.
E. Moore, Newson, R., Joshi, M., Palmer, T., Rothnie, K. J., Singh, S., Majeed, A., Soljak, M., and Quint, J. K., Effects of Pulmonary Rehabilitation on Exacerbation Number and Severity in People With COPD: An Historical Cohort Study Using Electronic Health Records, Chest, vol. 152, pp. 1188-1202, 2017.
H. Whittaker, Connell, O., Campbell, J., Elbehairy, A. F., Hopkinson, N. S., and Quint, J. K., Eligibility for Lung Volume Reduction Surgery in Chronic Obstructive Pulmonary Disease patients identified in a UK primary care setting, Chest, 2019.
L. Horne, Ashfaq, A., MacLachlan, S., Sinsakul, M., Qin, L., LoCasale, R., and Wetmore, J. B., Epidemiology and health outcomes associated with hyperkalemia in a primary care setting in England, BMC Nephrol, vol. 20, p. 85, 2019.
P. P. Toth, Danese, M., Villa, G., Qian, Y., Beaubrun, A., Lira, A., and Jansen, J. P., Estimated burden of cardiovascular disease and value-based price range for evolocumab in a high-risk, secondary-prevention population in the US payer context, J Med Econ, vol. 20, pp. 555-564, 2017.
C. I. Bloom, Nissen, F., Douglas, I. J., Smeeth, L., Cullinan, P., and Quint, J. K., Exacerbation risk and characterisation of the UK's asthma population from infants to old age, Thorax, vol. 73, pp. 313-320, 2018.
D. R. Morales, Flynn, R., Zhang, J., Trucco, E., Quint, J. K., and Zutis, K., External validation of ADO, DOSE, COTE and CODEX at predicting death in primary care patients with COPD using standard and machine learning approaches, Respir Med, vol. 138, pp. 150-155, 2018.
C. L. Morgan, Qiao, Q., Grandy, S., Johnsson, K., Jenkins-Jones, S., Holden, S., and Currie, C. J., Glucose Control and Weight Change Associated with Treatment with Exenatide Compared with Basal Insulin: A Retrospective Study, Diabetes Ther, vol. 9, pp. 269-283, 2018.
S. E. Holden, Morgan, C. L., Qiao, Q., Jenkins-Jones, S., Berni, E. R., and Currie, C. J., Healthcare resource utilization and related financial costs associated with glucose lowering with either exenatide or basal insulin: A retrospective cohort study, Diabetes Obes Metab, vol. 19, pp. 1097-1105, 2017.
M. Pikoula, Quint, J. K., Nissen, F., Hemingway, H., Smeeth, L., and Denaxas, S., Identifying clinically important COPD sub-types using data-driven approaches in primary care population based electronic health records, BMC Med Inform Decis Mak, vol. 19, p. 86, 2019.
E. R. Millett, Quint, J. K., De Stavola, B. L., Smeeth, L., and Thomas, S. L., Improved incidence estimates from linked vs. stand-alone electronic health records, J Clin Epidemiol, vol. 75, pp. 66-9, 2016.
S. F. Weng, Kai, J., H. Neil, A., Humphries, S. E., and Qureshi, N., Improving identification of familial hypercholesterolaemia in primary care: derivation and validation of the familial hypercholesterolaemia case ascertainment tool (FAMCAT), Atherosclerosis, vol. 238, pp. 336-43, 2015.
C. I. Bloom, Walker, S., and Quint, J. K., Inadequate specialist care referrals for high-risk asthma patients in the UK: an adult population-based cohort 2006-2017, J Asthma, pp. 1-7, 2019.
J. A. Kaye, Derby, L. E., M. Melero-Montes, delMar, Quinn, M., and Jick, H., The incidence of breast cancer in the General Practice Research Database compared with national cancer registration data, Br J Cancer, vol. 83, pp. 1556-8, 2000.
E. R. Millett, Quint, J. K., Smeeth, L., Daniel, R. M., and Thomas, S. L., Incidence of community-acquired lower respiratory tract infections and pneumonia among older adults in the United Kingdom: a population-based study, PLoS One, vol. 8, p. e75131, 2013.
A. Gayle, Dickinson, S., Poole, C., Pang, M., Fauconnot, O., and Quint, J. K., Incidence of type II diabetes in chronic obstructive pulmonary disease: a nested case-control study, NPJ Prim Care Respir Med, vol. 29, p. 28, 2019.
A. S. Khashan, Quigley, E. M., McNamee, R., McCarthy, F. P., Shanahan, F., and Kenny, L. C., Increased risk of miscarriage and ectopic pregnancy among women with irritable bowel syndrome, Clin Gastroenterol Hepatol, vol. 10, pp. 902-9, 2012.
H. R. Whittaker, Mullerova, H., Jarvis, D., Barnes, N. C., Jones, P. W., Compton, C. H., Kiddle, S. J., and Quint, J. K., Inhaled corticosteroids, blood eosinophils, and FEV1 decline in patients with COPD in a large UK primary health care setting, Int J Chron Obstruct Pulmon Dis, vol. 14, pp. 1063-1073, 2019.
H. Qiu, Rhoads, G. G., Berlin, J. A., Marcella, S. W., and Demissie, K., Initial metformin or sulphonylurea exposure and cancer occurrence among patients with type 2 diabetes mellitus, Diabetes Obes Metab, vol. 15, pp. 349-57, 2013.
R. K. Akyea, Kai, J., Qureshi, N., Iyen, B., and Weng, S. F., LDL cholesterol response to statins and future risk of cardiovascular disease, Heart, vol. 105, pp. 1290-1291, 2019.
T. A. Simon, Smitten, A. L., Franklin, J., Askling, J., Lacaille, D., Wolfe, F., Hochberg, M. C., Qi, K., and Suissa, S., Malignancies in the rheumatoid arthritis abatacept clinical development programme: an epidemiological assessment, Ann Rheum Dis, vol. 68, pp. 1819-26, 2009.
K. J. Rothnie, Connell, O., Mullerova, H., Smeeth, L., Pearce, N., Douglas, I., and Quint, J. K., Myocardial Infarction and Ischemic Stroke after Exacerbations of Chronic Obstructive Pulmonary Disease, Ann Am Thorac Soc, vol. 15, pp. 935-946, 2018.
K. J. Rothnie, Mullerova, H., Smeeth, L., and Quint, J. K., Natural History of Chronic Obstructive Pulmonary Disease Exacerbations in a General Practice-based Population with Chronic Obstructive Pulmonary Disease, Am J Respir Crit Care Med, vol. 198, pp. 464-471, 2018.
C. Windsor, Herrett, E., Smeeth, L., and Quint, J. K., No association between exacerbation frequency and stroke in patients with COPD, Int J Chron Obstruct Pulmon Dis, vol. 11, pp. 217-25, 2016.
E. L. Axson, Bloom, C. I., and Quint, J. K., Nontuberculous mycobacterial disease managed within UK primary care, 2006-2016, Eur J Clin Microbiol Infect Dis, vol. 37, pp. 1795-1803, 2018.
C. I. Bloom, Ricciardi, F., Smeeth, L., Stone, P., and Quint, J. K., Predicting COPD 1-year mortality using prognostic predictors routinely measured in primary care, BMC Med, vol. 17, p. 73, 2019.
S. F. Weng, Vaz, L., Qureshi, N., and Kai, J., Prediction of premature all-cause mortality: A prospective general population cohort study comparing machine-learning and standard epidemiological approaches, PLoS One, vol. 14, p. e0214365, 2019.
Y. Qian and Jick, S., Proton pump inhibitor use and myocardial infarction: a nested study in the UK Clinical Practice Research Datalink, Epidemiology, 2019.
C. Linde, Bakhai, A., Furuland, H., Evans, M., McEwan, P., Ayoubkhani, D., and Qin, L., Real-World Associations of Renin-Angiotensin-Aldosterone System Inhibitor Dose, Hyperkalemia, and Adverse Clinical Outcomes in a Cohort of Patients With New-Onset Chronic Kidney Disease or Heart Failure in the United Kingdom, J Am Heart Assoc, vol. 8, p. e012655, 2019.
K. Wing, Williamson, E., Carpenter, J. R., Wise, L., Schneeweiss, S., Smeeth, L., Quint, J. K., and Douglas, I., Real-world effects of medications for chronic obstructive pulmonary disease: protocol for a UK population-based non-interventional cohort study with validation against randomised trial results, BMJ Open, vol. 8, p. e019475, 2018.
[Page last reviewed 8 April 2020]