Research using CPRD data has informed drug safety guidance and clinical practice and resulted in over 2,500 peer-reviewed publications. The CPRD bibliography is updated on a monthly basis (last updated 7 September 2020) and papers are listed below and in the PDF below.

If you have published papers using CPRD data which are not included in this list, please contact us at so that we can update the bibliography.


 (PDF, 3MB, 209 pages) 

This work uses data provided by patients and collected by the NHS as part of their care and support. CPRD encourages researchers to use this citation in all publications using CPRD data. Find out more about acknowledging the use of patient data at the Understanding Patient Data website



Export 22 results:
Author Title [ Type(Desc)] Year
Filters: Author is Bottle, A.  [Clear All Filters]
Journal Article
B. Hayhoe, Kim, D., Aylin, P. P., Majeed, F. A., Cowie, M. R., and Bottle, A., Adherence to guidelines in management of symptoms suggestive of heart failure in primary care, Heart, 2018.
C. Tsang, Bottle, A., Majeed, A., and Aylin, P., Adverse events recorded in English primary care: observational study using the General Practice Research Database, Br J Gen Pract, vol. 63, pp. e534-42, 2013.
E. P. Vamos, Pape, U. J., Bottle, A., Hamilton, F. L., Curcin, V., Ng, A., Molokhia, M., Car, J., Majeed, A., and Millett, C., Association of practice size and pay-for-performance incentives with the quality of diabetes management in primary care, Cmaj, vol. 183, pp. E809-16, 2011.
C. Tsang, Bottle, A., Majeed, A., and Aylin, P., Cancer diagnosed by emergency admission in England: an observational study using the general practice research database, BMC Health Serv Res, vol. 13, p. 308, 2013.
C. S. Arhi, Bottle, A., Burns, E. M., Clarke, J. M., Aylin, P., Ziprin, P., and Darzi, A., Comparison of cancer diagnosis recording between the Clinical Practice Research Datalink, Cancer Registry and Hospital Episodes Statistics, Cancer Epidemiol, vol. 57, pp. 148-157, 2018.
C. S. Arhi, Markar, S., Burns, E. M., Bouras, G., Bottle, A., Hanna, G., Aylin, P., Ziprin, P., and Darzi, A., Delays in referral from primary care are associated with a worse survival in patients with esophagogastric cancer, Dis Esophagus, 2019.
C. S. Arhi, Burns, E. M., Bottle, A., Bouras, G., Aylin, P., Ziprin, P., and Darzi, A., Delays in referral from primary care worsen survival for patients with colorectal cancer: a retrospective cohort study, Br J Gen Pract, vol. 70, pp. e463-e471, 2020.
A. Bottle, Kim, D., Hayhoe, B., Majeed, A., Aylin, P., Clegg, A., and Cowie, M. R., Frailty and comorbidity predict first hospitalisation after heart failure diagnosis in primary care: population-based observational study in England, Age Ageing, 2019.
E. Cecil, Bottle, A., Ma, R., Hargreaves, D. S., Wolfe, I., ,, and Saxena, S., Impact of preventive primary care on children's unplanned hospital admissions: a population-based birth cohort study of UK children 2000-2013, BMC Med, vol. 16, p. 151, 2018.
J. Blackwell, Saxena, S., Alexakis, C., Bottle, A., Cecil, E., Majeed, A., and Pollok, R. C., The impact of smoking and smoking cessation on disease outcomes in ulcerative colitis: a nationwide population-based study, Aliment Pharmacol Ther, vol. 50, pp. 556-567, 2019.
G. Bouras, Burns, E. M., Howell, A. M., Bottle, A., Athanasiou, T., and Darzi, A., Linked hospital and primary care database analysis of the impact of short-term complications on recurrence in laparoscopic inguinal hernia repair, Hernia, vol. 21, pp. 191-198, 2017.
A. Rao, Kim, D., Darzi, A., Majeed, A., Aylin, P., and Bottle, A., Long-term trends of use of health service among heart failure patients, Eur Heart J Qual Care Clin Outcomes, vol. 4, pp. 220-231, 2018.
C. Millett, Bottle, A., Ng, A., Curcin, V., Molokhia, M., Saxena, S., and Majeed, A., Pay for perfomance and the quality of diabetes management in individuals with and without co-morbid medical conditions, J R Soc Med, vol. 102, pp. 369-77, 2009.
J. Blackwell, Saxena, S., Jayasooriya, N., Bottle, A., Petersen, I., Hotopf, M., Alexakis, C., and Pollok, R. C., Prevalence and duration of gastrointestinal symptoms before diagnosis of Inflammatory Bowel Disease and predictors of timely specialist review: a population-based study, J Crohns Colitis, 2020.
G. Bouras, Markar, S. R., Burns, E. M., Huddy, J. R., Bottle, A., Athanasiou, T., Darzi, A., and Hanna, G. B., The psychological impact of symptoms related to esophagogastric cancer resection presenting in primary care: A national linked database study, Eur J Surg Oncol, vol. 43, pp. 454-460, 2017.
A. Bottle, Kim, D., Aylin, P. P., Majeed, F. A., Cowie, M. R., and Hayhoe, B., Real-world presentation with heart failure in primary care: do patients selected to follow diagnostic and management guidelines have better outcomes?, Open Heart, vol. 5, p. e000935, 2018.
A. Rao, Kim, D., Darzi, A., Majeed, A., Aylin, P., and Bottle, A., Regional variations in trajectories of long-term readmission rates among patients in England with heart failure, BMC Cardiovasc Disord, vol. 19, p. 86, 2019.
G. Bouras, Burns, E. M., Howell, A. M., Bottle, A., Athanasiou, T., and Darzi, A., Risk of Post-Discharge Venous Thromboembolism and Associated Mortality in General Surgery: A Population-Based Cohort Study Using Linked Hospital and Primary Care Data in England, PLoS One, vol. 10, p. e0145759, 2015.
A. Bottle, Kim, D., Aylin, P., Cowie, M. R., Majeed, A., and Hayhoe, B., Routes to diagnosis of heart failure: observational study using linked data in England, Heart, vol. 104, pp. 600-605, 2018.
E. L. Axson, Sundaram, V., Bloom, C. I., Bottle, A., Cowie, M. R., and Quint, J. K., Temporal Trends in the Incidence of Heart Failure among Patients with COPD and Its Association with Mortality, Ann Am Thorac Soc, 2020.
E. Koshy, Watt, H., Curcin, V., Bottle, A., Sharland, M., and Saxena, S., Tonsillectomy among children with low baseline acute throat infection consultation rates in UK general practices: a cohort study, BMJ Open, vol. 5, p. e006686, 2015.
J. Ruzangi, Blair, M., Cecil, E., Greenfield, G., Bottle, A., Hargreaves, D. S., and Saxena, S., Trends in healthcare use in children aged less than 15 years: a population-based cohort study in England from 2007 to 2017, BMJ Open, vol. 10, p. e033761, 2020.
[Page last reviewed 7 September 2020]