Approved studies using CPRD Data

Applications to access CPRD data for observational research are reviewed by the Independent Scientific Advisory Committee (ISAC). Approval by ISAC is required for researchers to carry out their proposed studies.

A summary of all ISAC-approved protocols, including a lay and technical summary of the proposed research, is published three months after researchers have access to the data to begin their study.

The table below includes all ISAC-approved protocols submitted to CPRD from 1st July 2015. Searches can be carried out using applicant names, approval date or by using key words within the protocol title. Protocols below are listed in order of date of approval.


ISAC Approval Date Title
20/07/2018 Using electronic health records to assess effectiveness of national policy in dementia recognition in the UK
10/07/2018 The combine effect of renin angiotensin aldosterone system blockage and Sodium-glucose co-transporter-2 receptor inhibition on renal outcomes in type 2 diabetes
04/07/2018 Prognostic relevance of severe hypoglycaemia and factors associated with poor outcomes in subjects experiencing severe hypoglycaemia
28/06/2018 Risk factors for overtreatment and undertreatment of glucose-control in patients with diabetes mellitus and association of overtreatment with mortality
20/06/2018 The impact of not speaking English as a first language on diabetes control and outcomes in primary care
15/06/2018 Health benefits of sustained weight loss in people with overweight or obesity
08/06/2018 The cumulative incidence of seizures during 21 days after new use of oral antibiotics - a cohort study
08/06/2018 Prescribing of high dose oral ibuprofen (more than 1800mg/day) in UK primary care
08/06/2018 Replication of the Rivaroxaban Once Daily Oral Direct Factor Xa Inhibition Compared with Vitamin K Antagonism for Prevention of Stroke and Embolism Trial in Atrial Fibrillation (ROCKET AF) in a cohort study using electronic primary care data
01/06/2018 Determinants associated with treatment modification in the first year of treatment in patients with type 2 diabetes mellitus in the United Kingdom, before and after implementation of the new guideline: a retrospective cohort study
01/06/2018 Rate and risk of cardiovascular events and all-cause mortality in individuals with type 2 diabetes, with and without microalbuminuria - a cohort study in the CPRD database
30/05/2018 Persistence and adherence to controlled release formulations of sodium valproate for the treatment of epilepsy and their clinical and resource use implications.
30/05/2018 Reproducible Evidence: Practices to Enhance and Achieve Transparency (REPEAT): Study 6 - Replication of "Glucagon-like peptide-1 analogues and risk of breast cancer in women with type 2 diabetes: population based cohort study using the UK CPRD"
22/05/2018 Evaluation of the Burden and Management of Musculoskeletal Diseases
22/05/2018 The Association of oral bisphosphonate use with mortality risk following a major osteoporotic fracture in the UK
21/05/2018 Blood eosinophilia, withdrawal of inhaled corticosteroids and risk of COPD exacerbations and mortality
21/05/2018 Trends in acute exacerbation and related hospitalization among COPD patients in the UK (2005-2013)
17/05/2018 An investigation into the effect of quality of antenatal care on the risk of stillbirths in the UK
15/05/2018 Is seasonal influenza vaccine effectiveness reduced in people receiving repeat vaccinations? A retrospective cohort study using the Clinical Practice Research Database
15/05/2018 Developing indicators for failure or delays in recognising clinical deterioration and escalation of care across primary care