Approved studies using CPRD Data

Applications to access CPRD data for observational research are reviewed by the Independent Scientific Advisory Committee (ISAC). Approval by ISAC is required for researchers to carry out their proposed studies.

A summary of all ISAC-approved protocols, including a lay and technical summary of the proposed research, is published three months after researchers have access to the data to begin their study. COVID-19 research protocols are being fast-tracked and all approved summaries are published within 72 hours to ensure transparency and to help avoid unnecessary duplication.

The table below includes all ISAC-approved protocols submitted to CPRD from 1st July 2015. Protocols below are listed in order of date of approval. Please click on the study title for more details.

Peer-reviewed publications from research using CPRD data will be listed on our bibliography page


Impact of the COVID-19 Crisis on Treatments, Natural History, Health Care Resource Utilisation, and Medical Cost in Hypertrophic Cardiomyopathy in England
The Impact of COVID-19 lockdown on the lives of People with Obesity (PwO): A UK primary care based study
Healthcare utilisation, symptoms, prescriptions and new disease in people with COVID-19 managed in the community or hospital
CORYLUS UK: A retrospective observational cohort study of the impact of COVID-19 on systemic lupus erythematosus patients in England using data from linked primary and secondary care databases
The direct and indirect effects of Covid-19 on long-term conditions: A retrospective cohort study using primary and secondary care electronic health records
COVID-19 recording in Clinical Practice Research Datalink primary care data and linked Second Generation Surveillance System SARS-CoV-2 virology test data
Real world evidence in asthma and chronic obstructive pulmonary disease to understand the burden of COVID-19 infection in United Kingdom
Cohort study of risk factors of acute and chronic cardiovascular events in COVID-19 patients
The descriptive epidemiology of Adverse Events of Special Interest for COVID-19 and other vaccines in the general population and after seasonal influenza and COVID-19 disease
Impact of COVID-19 pandemic on routine clinical management of patients with neurological diseases: a descriptive retrospective cohort study
Investigating the effect of cardiovascular risk level on severe outcomes of COVID-19
Understanding the association between diabetes and severe COVID-19 infection
Feasibility analysis of a European infrastructure for COVID-19 vaccine monitoring: Background rates of Adverse Events of Special Interest
Acute and long-term health outcomes for people who survived COVID-19: matched cohort analyses using UK primary and secondary care data
MuSculoskeletal paiN durIng the COVID-19 PandEmic: an observational study of UK national primary care electronic health records (the SNIPE Study)
Near real time vaccine safety monitoring for COVID-19 vaccines
Excess mortality during the COVID-19 pandemic
Indirect acute effects of the COVID-19 pandemic on physical and psychological morbidity in the UK
Using linked primary care and viral surveillance data to develop risk stratification models to inform management of severe COVID-19
An investigation of excess mortality and end-of-life morbidity patterns before and during the COVID-19 pandemic. A retrospective analysis using primary care data