Approved studies using CPRD Data

Applications to access CPRD data for observational research are reviewed by the Independent Scientific Advisory Committee (ISAC). Approval by ISAC is required for researchers to carry out their proposed studies.

A summary of all ISAC-approved protocols, including a lay and technical summary of the proposed research, is published three months after researchers have access to the data to begin their study.

The table below includes all ISAC-approved protocols submitted to CPRD from 1st July 2015. Protocols below are listed in order of date of approval. Please click on the study title for more details.

Peer-reviewed publications from research using CPRD data will be listed on our bibliography page


ISAC Approval Date Title
15/05/2020 Diagnosis and management of infectious disease in primary care during the COVID-19 lockdown: changes in antibacterial and antiviral use
05/05/2020 Antimicrobial stewardship during the COVID-19 epidemic. Cohort study
05/05/2020 Consultations for non-specific symptoms commonly reported with COVID-19 and other acute respiratory infections in the Clinical Practice Research Datalink: long term trends and patient characteristics
27/04/2020 Underlying conditions in coronavirus (COVID-19) infection: definition, prevalence, mortality and understanding risk
20/04/2020 COVID-19 related risks in cancer survivors: a matched cohort study using linked UK electronic health records data
20/04/2020 Psychological distress associated with the current COVID-19 outbreak: evidence from electronic health records
16/04/2020 COVID-19 and drugs acting on the renin angiotensin system
09/04/2020 Pharmacological risk factors for COVID-19 infection: a matched prospective cohort study of patients in primary care
25/03/2020 Identifying risk factors for infection with the new coronavirus (COVID-19)
23/03/2020 Characterisation, prediction of complications, and safety of emergent therapies for viral outbreaks and pneumonia: a rapid network study to inform management of COVID-19
27/02/2020 Association of diabetes control on the risk of venous thrombosis: a nested case control study
07/02/2020 Cardiovascular comorbidity prevalence in males with haemophilia A
17/01/2020 Examining neurologic and thromboembolic risks when using skeletal muscle relaxants with warfarin
06/01/2020 Use of electronic primary care records to obtain control populations for assessing excess risk of long-term morbidity and mortality in chronic diseases
20/12/2019 Comparative effectiveness and safety of angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers on the risk of major cardiovascular events, cancer and renal outcomes
13/12/2019 Assessment of production batch information of vaccines in the Clinical Practice Research Datalink
27/11/2019 Spillover effects of removing indicators from the Quality and Outcomes Framework
11/11/2019 Incidence of adverse events among adult users of insulin and apomorphine pumps in the United Kingdom Clinical Practice Research Datalink GOLD: a descriptive study
01/11/2019 Patient and clinical characteristics of new users to single or multiple inhaled triple therapy in patients with COPD in the UK
09/10/2019 Characterization of the deterioration of type 2 diabetes in patients with a subsequent diagnosis of pancreatic cancer - A descriptive study