Approved studies using CPRD Data

Applications to access CPRD data for observational research are reviewed by the Independent Scientific Advisory Committee (ISAC). Approval by ISAC is required for researchers to carry out their proposed studies.

A summary of all ISAC-approved protocols, including a lay and technical summary of the proposed research, is published three months after researchers have access to the data to begin their study.

The table below includes all ISAC-approved protocols submitted to CPRD from 1st July 2015. Searches can be carried out using applicant names, approval date or by using key words within the protocol title. Protocols below are listed in order of date of approval.


ISAC Approval Date Title
22/02/2019 The association between fracture risk and diabetes duration, complications and regulation in diabetes mellitus
12/02/2019 Use of Sodium-glucose co-transporter-2 inhibitors, changes in body mass index and risk of major osteoporotic fracture
11/02/2019 The weight loss effects of glucagon-like peptide-1 receptor agonists and the risk of breast cancer in women with type 2 diabetes
08/02/2019 Trends in incidence of first diabetic foot ulcer and mortality in patients with T1 AND T2 DM
29/01/2019 Incidence of major adverse cardiovascular and cerebrovascular events (MACE) in patients with psoriasis, psoriatic arthritis and ankylosing spondylitis: a retrospective analysis of a United Kingdom database
24/01/2019 C-reactive protein as a biomarker of response to inhaled corticosteroids in COPD
17/01/2019 Effectiveness of long acting muscarinic-antagonist- (LAMA) as an add-on to inhaled corticosteroids / long acting beta-agonists (LABA) in smoking asthmatics
17/01/2019 Dose adjustment or discontinuous use of direct oral anticoagulants related to the concurrent use of potential interacting drugs
21/12/2018 The pattern of incident fractures in patients with diabetes mellitus compared to matched controls
19/12/2018 The Health Economic Burden of Atopic Dermatitis and Associated Dermatologic Conditions: A Study of Cow's Milk Allergy (CMA) in patients > 5 years of age in the Primary and Secondary Care Pathways
11/12/2018 Reproducible Evidence: Practices to Enhance and Achieve Transparency (REPEAT): Study 3 -Replication of "Non-persistence and non-adherence of patients with Type 2 Diabetes Mellitus in Therapy with GLP-1 Receptor Agonists: A Retrospective Analysis"
05/12/2018 Reproducible Evidence: Practices to Enhance and Achieve Transparency (REPEAT): Study 20 - Replication of "Risk of Death and Cardiovascular Outcomes with Thiazolidinediones: A Study with the General Practice Research Database and Secondary Care Data"
30/11/2018 REPEAT Study 17 - Replication of "Risk of major bleeding and stroke associated with the use of vitamin K antagonists, nonvitamin K antagonist oral anticoagulants and aspirin in patients with atrial fibrillation: a cohort study"
30/11/2018 Prescriptions for antibiotics in childhood and risk of inflammatory bowel disease: A matched case-control study in the UK Clinical Practice Research Datalink
26/11/2018 The impact of knee replacement on mortality in the presence of chronic disease
22/11/2018 Trends in the prescribing of opioids for non-malignant pain in UK primary care: a descriptive study
21/11/2018 The prevalence of co-prescribing of tramadol and antidepressants during 1998-2017, and associated risk of all-cause mortality and emergency hospital admissions
21/11/2018 Missed opportunities for limb salvage in patients undergoing major amputation - a retrospective cohort study of the clinical practice research datalink
19/11/2018 Risk of hospitalised Influenza, England, 2000-2017
19/11/2018 Estimating the incidence of acute complications of herpes zoster: a matched cohort study using UK healthcare data