Approved studies using CPRD Data

Access to CPRD data, including UK Primary Care Data, and linked data such as Hospital Episode Statistics, is subject to protocol approval via CPRD’s Research Data Governance (RDG) Process. Independent scientific and patient advice is provided by Expert Review Committees (ERCs) and the Central Advisory Committee (CAC). 

A summary of all approved protocols, including a lay and technical summary of the proposed research, is published three months after researchers have access to the data to begin their study. COVID-19 research protocols are being fast-tracked and all approved summaries are published within 72 hours to ensure transparency and to help avoid unnecessary duplication. 

Protocols below are listed in order of date of approval. Please click on the study title for more details. 

Peer-reviewed publications from research using CPRD data will be listed on our bibliography page


Date of Approval Title
08/12/2016 Alternative methods to account for patients with a prior history of treatment in comparative effectiveness studies: an illustration with insulin glargine and breast cancer
08/12/2016 Diabetes, glycaemic control and risk of infectious disease: cohort and case-crossover studies in primary care
08/12/2016 What is the incidence of Developmental Dysplasia of the Hip requiring intervention, and what proportion are diagnosed after six months of age?
08/12/2016 Prolonged Effects of Assisted reproductive technologies on the health of women and their children: a Record Linkage study for England (PEARL)
08/12/2016 Equitable access to smoking cessation therapies for older smokers
08/12/2016 Burden of Hyperkalemia among individuals seeking health care services in England
08/12/2016 Patterns of LDL-C lowering by Statins and their association with Cardiovascular Outcomes in the General Population
08/12/2016 A comparison of the EMPA-REG OUTCOME clinical trial population with T2DM patients treated in the routine clinical practice: An exploratory study using the Clinical Practice Research Datalink (CPRD).
08/12/2016 Drug utilisation study of new users of fluticasone furoate / vilanterol (FF/VI) in the primary care setting
08/12/2016 Pericarditis diagnosis in the CPRD: a potential early indicator of undetected cancer and marker of subsequent increased cancer risk
08/12/2016 Understanding the diagnostic pathway for brain tumours in adults and its potential impact on clinical care and outcomes
08/12/2016 Development and validation of risk prediction equations and the burden of Hyperkalemia: a retrospective cohort study using routinely collected clinical practice data
08/12/2016 Association of Polycystic Ovary Syndrome with patient and offspring mental health outcomes: a retrospective, observational study
09/12/2016 The association between body mass index and acute kidney injury at start and during hospitalisation
09/12/2016 Using Big data Research to tackle antIbiotic resisTance (BRIT)
12/12/2016 The risk of hypomagnesemia and electrolyte disturbances associated with the use of long-term proton pump Inhibitor: a population-based cohort study.
16/12/2016 Post-authorization Safety Study: Evaluation of Neoplasm Events in Users of Mirabegron and Other Treatments for Overactive Bladder in the CPRD
20/12/2016 Assessing the association between incretin-based drugs and the incidence of colon cancer in patients with type 2 diabetes
20/12/2016 A data-driven approach for identifying falls subgroups through semantic similarity analysis
21/12/2016 Prescribing of antidiabetic drug therapy and comparative incidence of outcomes associated with Type 2 Diabetes