Approved studies using CPRD Data

Access to CPRD data, including UK Primary Care Data, and linked data such as Hospital Episode Statistics, is subject to protocol approval via CPRD’s Research Data Governance (RDG) Process. Independent scientific and patient advice is provided by Expert Review Committees (ERCs) and the Central Advisory Committee (CAC). 

A summary of all approved protocols, including a lay and technical summary of the proposed research, is published three months after researchers have access to the data to begin their study. COVID-19 research protocols are being fast-tracked and all approved summaries are published within 72 hours to ensure transparency and to help avoid unnecessary duplication. 

Protocols below are listed in order of date of approval. Please click on the study title for more details. 

Peer-reviewed publications from research using CPRD data will be listed on our bibliography page


Date of Approval Title
21/12/2016 Cohort study assessing the association between hormone therapy use in female breast cancer survivors and subsequent risk of cardiovascular diseases in the UK
22/12/2016 An evaluation of the epidemiology and burden of illness of food allergy in the United Kingdom
22/12/2016 Neuroprotective Effects of Minocycline in Schizophrenia Patients: Retrospective Cohort Studies Using the Clinical Practice Research Datalink
10/01/2017 Eczema and Dry Skin - Observational Analysis of Patients Prescription Patterns and Healthcare Utilization
10/01/2017 The role of statins in the survival of total arthroplasty of the hip and knee.
10/01/2017 A population-based assessment of the cardiovascular effects of 5-alpha reductase inhibitors
11/01/2017 Proton pump inhibitor use and risk of iron deficiency: a case-control study.
13/01/2017 Stevens-Johnson syndrome (SJS) and Toxic Epidermal Necrolysis (TEN): A case control study using the Clinical Practice Research Datalink (CPRD).
13/01/2017 How do we better understand the current management of patients with Chronic Rhinosinusitis within the National Health Service?
13/01/2017 Characterising the primary care population with frailty to better stratify and target healthcare interventions
13/01/2017 A nested case-controlled study of the association between incident pneumonia, dysphagia and the formulation of commonly prescribed medication among people with dementia.
13/01/2017 The incidence and mortality of complicated diverticular disease and associated outcomes following intervention
16/01/2017 Use of hormone replacement therapy and risk of breast cancer
18/01/2017 Potential benefits of antithrombotic treatment in reducing risk of subsequent cardiovascular events among patients with a prior myocardial infarction in England
19/01/2017 Determining incidence of patient safety events in primary care using patient record data
23/01/2017 Effects of changing pre-eclampsia management on acute renal failure and other maternal and perinatal outcomes in the United Kingdom: An interrupted time-series analysis
23/01/2017 Derivation and validation of statistical models to forecast acute death and longer term survival in people with cirrhosis
23/01/2017 The Use of Angiotensin Converting Enzyme Inhibitors and the Risk of Lung Cancer
23/01/2017 Utilising electronic health records to investigate the association of liver function tests with incidence and outcomes of gastrointestinal disease and malignancy
23/01/2017 RAASi use patterns following incident hyperkalemia in England