Approved studies using CPRD Data

Access to CPRD data, including UK Primary Care Data, and linked data such as Hospital Episode Statistics, is subject to protocol approval via CPRD’s Research Data Governance (RDG) Process. Independent scientific and patient advice is provided by Expert Review Committees (ERCs) and the Central Advisory Committee (CAC). 

A summary of all approved protocols, including a lay and technical summary of the proposed research, is published three months after researchers have access to the data to begin their study. COVID-19 research protocols are being fast-tracked and all approved summaries are published within 72 hours to ensure transparency and to help avoid unnecessary duplication. 

Protocols below are listed in order of date of approval. Please click on the study title for more details. 

Peer-reviewed publications from research using CPRD data will be listed on our bibliography page


Date of Approval Title
18/04/2018 Trends in antipsychotic prescribing for children in UK primary care
18/04/2018 Antibiotic Choice in UK General Practice - rates and drivers of potentially inappropriate antibiotic type in UK general practices
18/04/2018 A retrospective observational study describing the health impact of SABA over-prescription and ICS under-prescription among asthma patients
18/04/2018 Pharmaco-Epidemiological Study of Cardio-Respiratory Safety of Beta2-agonists for the Treatment and Management of Asthma-COPD Overlap Syndrome
20/04/2018 Identifying and Evaluating Modifiers of Subsequent Event Risk among Patients with Established Coronary Heart Disease
20/04/2018 Management of hyperthyroidism in pregnancy; data from a large UK primary care cohort
20/04/2018 Mapping the Multimorbidity Burden in Patients with Type-2 Diabetes Mellitus and Coronary Heart Disease
20/04/2018 Prescription medications for cardiovascular disease and metabolic syndrome and risk of endometrial and ovarian cancer in the Clinical Practice Research Datalink
25/04/2018 The effect of smoking on post-operative complications following hip or knee joint replacement
25/04/2018 Unmet Needs, Symptom Burden, and Health Care Utilisation of Chronic Obstructive Pulmonary Disease (COPD) Patients Receiving Respiratory Maintenance Therapy in the United Kingdom (UK)
25/04/2018 Mapping opportunities for earlier detection of Bipolar Disorder - Linking big data to improve patient outcomes (MOBILISE)
26/04/2018 5-ASA in Crohn's Disease: The CROHN'S Investigation (Clinical and treatment Resource use, patient Outcomes and Health impact using National prescribing Systems)
26/04/2018 Are improvements in chronic respiratory disease management in England associated with reductions in excess mortality?
26/04/2018 A cohort study of infections and lymphopenia in eczema
26/04/2018 Blood Eosinophil Levels and Severe Asthma Exacerbations Among Paediatric Patients with Asthma in the English Primary Care Setting
27/04/2018 Using Predictive Analytics to Improve Patient Outcomes in Neuroendocrine Tumours
30/04/2018 The epidemiology and healthcare burden of opioid therapy in the United Kingdom
30/04/2018 The impact of type 2 diabetes on survival in patients with cancer independent of its effect on survival in individuals without cancer: a matched cohort analysis
30/04/2018 Health care use and cost trajectories of people in the last year of life : improving planning and resource allocation in end of life care
30/04/2018 Mortality and morbidity effects of long-term exposure to low-level PM2.5, Black Carbon, NO2 and O3: an analysis of European cohorts