Approved studies using CPRD Data

Access to CPRD data, including UK Primary Care Data, and linked data such as Hospital Episode Statistics, is subject to protocol approval via CPRD’s Research Data Governance (RDG) Process. Independent scientific and patient advice is provided by Expert Review Committees (ERCs) and the Central Advisory Committee (CAC). 

A summary of all approved protocols, including a lay and technical summary of the proposed research, is published three months after researchers have access to the data to begin their study. COVID-19 research protocols are being fast-tracked and all approved summaries are published within 72 hours to ensure transparency and to help avoid unnecessary duplication. 

Protocols below are listed in order of date of approval. Please click on the study title for more details. 

Peer-reviewed publications from research using CPRD data will be listed on our bibliography page


Date of Approval Title
22/05/2018 Seasonal Influenza Vaccine Effectiveness and Safety in Asthma
22/05/2018 Evaluation of the Burden and Management of Musculoskeletal Diseases
22/05/2018 The Association of oral bisphosphonate use with mortality risk following a major osteoporotic fracture in the UK
22/05/2018 Long-term relative effectiveness of monotherapy antihypertensive drugs in patients newly diagnosed with hypertension. A cohort study in the UK Clinical Practice Research Datalink (CPRD)
23/05/2018 Population characteristics and treatment patterns by renal function status in type II diabetes: A population-based cohort study
23/05/2018 Acute exacerbation of idiopathic pulmonary fibrosis in the UK: incidence, mortality and disease severity
23/05/2018 Use of non-steroidal anti-inflammatory drugs and risk of acute myocardial infarction in patients undergone total hip or knee replacement surgery: a population-based cohort study
25/05/2018 Up-titration and distribution of dose of metformin monotherapy in the real-world
25/05/2018 How does use of secondary prevention medication after stroke vary between different patient groups?
30/05/2018 Reproducible Evidence: Practices to Enhance and Achieve Transparency (REPEAT): Study 11 - Replication of "Co-administration of statins with cytochrome P450 3A4 inhibitors in a UK primary care population"
30/05/2018 Reproducible Evidence: Practices to Enhance and Achieve Transparency (REPEAT) Study 12 : “Quantification of the risk of liver injury associated with flucloxacillin: a UK population-based cohort study”
30/05/2018 Effect of stepping down (reducing) a stable asthma patient’s maintenance medication on the risk of an acute asthma attack
30/05/2018 Reproducible Evidence: Practices to Enhance and Achieve Transparency (REPEAT): Study 6 - Replication of "Glucagon-like peptide-1 analogues and risk of breast cancer in women with type 2 diabetes: population based cohort study using the UK CPRD"
30/05/2018 Persistence and adherence to controlled release formulations of sodium valproate for the treatment of epilepsy and their clinical and resource use implications.
01/06/2018 Determinants associated with treatment modification in the first year of treatment in patients with type 2 diabetes mellitus in the United Kingdom, before and after implementation of the new guideline: a retrospective cohort study
01/06/2018 Evaluating the NHS Diabetes Prevention Programme (NHS DPP): Assessing whether the NHS DPP is more effective than usual care in reducing conversion of nondiabetic hyperglycaemia to diabetes, eventually reducing diabetes prevalence in England
01/06/2018 Using CPRD to describe the current management of heart failure in England and model risk trajectories to improve shared decision-making
01/06/2018 Rate and risk of cardiovascular events and all-cause mortality in individuals with type 2 diabetes, with and without microalbuminuria - a cohort study in the CPRD database
08/06/2018 Prescribing of high dose oral ibuprofen (1800mg/day or more) in UK primary care
08/06/2018 The utilisation of linaclotide in patients with Irritable Bowel Syndrome predominantly with constipation (IBS-C) in the United Kingdom: a retrospective observational study using the Clinical Practice Research Datalink