Approved studies using CPRD Data

Access to CPRD data, including UK Primary Care Data, and linked data such as Hospital Episode Statistics, is subject to protocol approval via CPRD’s Research Data Governance (RDG) Process. Independent scientific and patient advice is provided by Expert Review Committees (ERCs) and the Central Advisory Committee (CAC). 

A summary of all approved protocols, including a lay and technical summary of the proposed research, is published three months after researchers have access to the data to begin their study. COVID-19 research protocols are being fast-tracked and all approved summaries are published within 72 hours to ensure transparency and to help avoid unnecessary duplication. 

Protocols below are listed in order of date of approval. Please click on the study title for more details. 

Peer-reviewed publications from research using CPRD data will be listed on our bibliography page


Date of Approval Title
08/06/2018 The cumulative incidence of seizures during 21 days after new use of oral antibiotics - a cohort study
08/06/2018 Replication of the Rivaroxaban Once Daily Oral Direct Factor Xa Inhibition Compared with Vitamin K Antagonism for Prevention of Stroke and Embolism Trial in Atrial Fibrillation (ROCKET AF) in a cohort study using electronic primary care data
08/06/2018 Retrospective cohort study to understand the natural history and burden of disease of Huntington’s disease in the United Kingdom
11/06/2018 Investigating the potential side effects of the human papillomavirus vaccine: a novel regression discontinuity analysis using the UK Clinical Practice Research Datalink
11/06/2018 Use of primary care and hospital services in children and young people aged less than 25 years in England; descriptive study
11/06/2018 Deriving parameters of long-term cardiovascular outcomes and health care utilisation for a cost-effectiveness model in patients with familial hypercholesterolaemia diagnosed in primary care
12/06/2018 Alzheimer’s disease subtype discovery in electronic health records using cluster analysis
14/06/2018 Descriptive Analysis of Pro-Arrhythmic Risk of Drug Therapies
15/06/2018 What influence does obesity have on healthcare utilisation cost for patients with and without cardiovascular diseases?
15/06/2018 Use of inhaled corticosteroids and risk of pneumonia in asthma
15/06/2018 Health benefits of sustained weight loss in people with overweight or obesity
15/06/2018 Comparing the effectiveness of COPD treatments in the UK
18/06/2018 Investigating healthcare utilisation for heart failure patients with or without cardiac implantable electronic devices in England: retrospective cohort study.
20/06/2018 The impact of not speaking English as a first language on diabetes control and outcomes in primary care
20/06/2018 Health Impact Assessment to predict the impact of an increase in tobacco pricing on the burden of COPD in Italy, Sweden and the United Kingdom
22/06/2018 Withdrawing inhaled corticosteroid (ICS) treatment in people with COPD: a real world study
22/06/2018 Prevalence, incidence, and natural history of gastroparesis in the United Kingdom: real world evidence from the Clinical Practice Research Datalink
28/06/2018 Risk factors for overtreatment and undertreatment of glucose-control in patients with diabetes mellitus and association of overtreatment with mortality
28/06/2018 Is herpes zoster associated with risk of incident dementia? A cohort study using the Clinical Practice Research Datalink.
04/07/2018 Prognostic relevance of severe hypoglycaemia and factors associated with poor outcomes in subjects experiencing severe hypoglycaemia