Approved studies using CPRD Data

Access to CPRD data, including UK Primary Care Data, and linked data such as Hospital Episode Statistics, is subject to protocol approval via CPRD’s Research Data Governance (RDG) Process. Independent scientific and patient advice is provided by Expert Review Committees (ERCs) and the Central Advisory Committee (CAC). 

A summary of all approved protocols, including a lay and technical summary of the proposed research, is published three months after researchers have access to the data to begin their study. COVID-19 research protocols are being fast-tracked and all approved summaries are published within 72 hours to ensure transparency and to help avoid unnecessary duplication. 

Protocols below are listed in order of date of approval. Please click on the study title for more details. 

Peer-reviewed publications from research using CPRD data will be listed on our bibliography page


Date of Approval Title
04/07/2018 A cohort study investigating the association of flucloxacillin and liver injury within people previously exposed to the drug
09/07/2018 Impact of ethnicity on the development of kidney disease in the UK, a retrospective database study
09/07/2018 Impact of atrial fibrillation (AF) awareness campaigns on the rate of AF related consultations in UK primary care: an interrupted time series analyses
09/07/2018 Risk Stratification and multimorbidity in Chronic Obstructive Pulmonary Disease (COPD)
09/07/2018 Understanding the role of serum electrolytes in the presentation of specific fatal and non-fatal cardiovascular disease syndromes: a research proposal using linked CPRD-HES-ONS data
10/07/2018 The extent of medication complexity in general practice
10/07/2018 The combine effect of renin angiotensin aldosterone system blockage and Sodium-glucose co-transporter-2 receptor inhibition on renal outcomes in type 2 diabetes
12/07/2018 Describing monotherapy and combination use in male and female patients with treatment for Lower Urinary Tract Symptoms. A retrospective, observational study using the UK CPRD
12/07/2018 Drug utilisation among primary care patients with knee osteoarthritis (KOA): a population-based study using CPRD
12/07/2018 Nested case-control study of the impact of PSA screening on prostate cancer mortality in England
12/07/2018 Describing treatment and survival of children with congenital heart anomalies
16/07/2018 Getting sustainable, person-centred musculoskeletal health intelligence from primary care electronic health record linkage and modelling: the PRELIM initiative – Work package 3
16/07/2018 Predicting risk of dementia using routine electronic health records
16/07/2018 Correlation of forced expiratory volume in one second with mortality and resource use in patients with asthma
16/07/2018 Use of renin angiotensin system inhibitors and incident treated depression, and nonfatal or fatal self-harm
16/07/2018 Risk factors of cardiovascular disease amongst users of anti-osteoporosis therapy/ies, patients with osteoporosis, or those suffering a fracture in the UK NHS: a cohort study
20/07/2018 Using electronic health records to assess effectiveness of national policy in dementia recognition in the UK
20/07/2018 A retrospective cohort study using the Clinical Practice Research Datalink to assess the proportion of pregnancy outcomes, pregnancy-related events of interest, and infant events of interest in pregnant women and their infants
20/07/2018 Dipeptidyl peptidase-4 inhibitors and the risk of bullous pemphigoid among patients with type 2 diabetes
20/07/2018 Serum cholesterol trajectories in the years prior to lymphoma diagnosis