Approved studies using CPRD Data

Access to CPRD data, including UK Primary Care Data, and linked data such as Hospital Episode Statistics, is subject to protocol approval via CPRD’s Research Data Governance (RDG) Process. Independent scientific and patient advice is provided by Expert Review Committees (ERCs) and the Central Advisory Committee (CAC). 

A summary of all approved protocols, including a lay and technical summary of the proposed research, is published three months after researchers have access to the data to begin their study. COVID-19 research protocols are being fast-tracked and all approved summaries are published within 72 hours to ensure transparency and to help avoid unnecessary duplication. 

Protocols below are listed in order of date of approval. Please click on the study title for more details. 

Peer-reviewed publications from research using CPRD data will be listed on our bibliography page


Date of Approval Title
20/07/2018 Discovery and characterization of heart failure sub phenotypes using cluster analysis methods in CPRD
20/07/2018 Better Targeting of Inhaled Corticosteroids in Chronic Obstructive Pulmonary Disease
23/07/2018 Evaluating effect modification using propensity score matching and disease risk score methods: an empirical study
23/07/2018 Long term impact of giving antibiotics before skin incision versus after cord clamping on children born by caesarean section: longitudinal study based on UK electronic health records
23/07/2018 Study of recovery in patients hospitalised with community acquired pneumonia using Clinical Practice Research Datalink (CPRD), linked to Hospital Episode Statistics
24/07/2018 Understanding the impact of the routine use of anti-diabetic (PPAR gamma)/anti-hyperlipidaemic (PPAR alpha) medication on risk of brain tumours and case fatality
24/07/2018 Determining the frequency of abnormal hepatic fibrosis measures and liver cirrhosis/decompensation in UK primary care
27/07/2018 A study of cardiovscular mortality and morbidity of patients with adrenal insufficiency
27/07/2018 Do NHS Health Checks improve patient's Diabetic Healthcare outcomes? A population-based study using the CPRD
01/08/2018 Bile acid sequestrants and risk of selected age-related diseases
01/08/2018 Asthma and Type 2 Co-morbidities
01/08/2018 Differences in Heart Failure Care and Survival: A Comparison between United Kingdom, Sweden, Netherlands and Spain using Linked Electronic Health Care Records
01/08/2018 Defining patient groups at short-term high risk of fracture and evaluating current practice of osteoporosis treatment and rate of different fractures and cardiovascular events in these patient groups
01/08/2018 Impact of subsequent major adverse cardiovascular events on mortality in a post-myocardial infarction population: a retrospective UK database analysis
01/08/2018 A study on the epidemiology of tinnitus in the United Kingdom
01/08/2018 Deriving Risk Equations for Complications of Type 2 Diabetes for the UK CPRD population
07/08/2018 Examining treatment patterns of antidepressant and antipsychotic prescriptions; and serious adverse events and the associated economic cost of antipsychotic drug use in people with dementia
07/08/2018 Assessing the effect of switching from an inhaler regimen containing inhaled corticosteroid to one without in a real-world COPD population
07/08/2018 Relationship between Body Mass Index (BMI) trajectory and the risk of cardiovascular disease and diabetes among overweight and obese people: A UK Primary Care-based cohort study
07/08/2018 M.A.P.P.E.D. IMproving the Accuracy of Psychosis PrEDiction using primary-care consultation data