Approved studies using CPRD Data

Access to CPRD data, including UK Primary Care Data, and linked data such as Hospital Episode Statistics, is subject to protocol approval via CPRD’s Research Data Governance (RDG) Process. Independent scientific and patient advice is provided by Expert Review Committees (ERCs) and the Central Advisory Committee (CAC). 

A summary of all approved protocols, including a lay and technical summary of the proposed research, is published three months after researchers have access to the data to begin their study. COVID-19 research protocols are being fast-tracked and all approved summaries are published within 72 hours to ensure transparency and to help avoid unnecessary duplication. 

Protocols below are listed in order of date of approval. Please click on the study title for more details. 

Peer-reviewed publications from research using CPRD data will be listed on our bibliography page


Date of Approval Title
08/08/2018 Fractures in people with intellectual disabilities: comparison with the general population and development of a fracture risk calculator specific to these patients
09/08/2018 Testing people with type 2 diabetes, hypertension or chronic kidney disease in United Kingdom primary care
09/08/2018 An assessment of CPRD Aurum data quality
09/08/2018 Characterising the renal function of newly diagnosed non-valvular atrial fibrillation patients
09/08/2018 Is polypharmacy associated with death or ischemic stroke in individuals newly diagnosed with atrial fibrillation? A prognostic cohort study using data from The Clinical Practice Research Datalink (CPRD)
14/08/2018 Do systemic antibiotics affect the effectiveness of chemotherapy for malignant cancers? - A cohort study based on CPRD and Cancer Registry data
14/08/2018 Variation in patient pathways and hospital admissions for exacerbations of COPD: linking the National Asthma and COPD Audit Programme (NACAP) with CPRD data
20/08/2018 Investigating associations between environmental factors and exacerbations of COPD and asthma
20/08/2018 Comparative Safety of the Sodium Glucose Co-transporter-2 (SGLT2) Inhibitors in Patients with Type 2 Diabetes
22/08/2018 Testosterone replacement therapy and the risk of prostate cancer in men with age-related hypogonadism
22/08/2018 Prediction of anticoagulation control and associated health economic outcomes in patients with atrial fibrillation (AF) managed on warfarin
22/08/2018 Assessing the Burden of Allergy Management in England
22/08/2018 The role of CA125 in the detection of ovarian cancer in symptomatic primary care patients
24/08/2018 Evaluation of natural history and health care resource utilisation of patients with monocloncal gammopathy of unknown significance and myeloma bone disease
28/08/2018 Developing and validating a measure of inappropriate polypharmacy
29/08/2018 Age at onset of multiple cardiovascular disease conditions: differences in ethnic subgroups by diabetes status
29/08/2018 A study to evaluate growth characteristics and burden of illness in patients with achondroplasia
29/08/2018 The relationship between partner bereavement and being diagnosed with dementia
29/08/2018 The burden of incontinence of urine associated with prostate cancer treatment: documenting the prevalence and highlighting the difference between prostate cancer treatment modalities
29/08/2018 General practice consulting behaviours prior to atrial fibrillation diagnosis: an investigation of potential opportunities for targeted screening