Approved studies using CPRD Data

Access to CPRD data, including UK Primary Care Data, and linked data such as Hospital Episode Statistics, is subject to protocol approval via CPRD’s Research Data Governance (RDG) Process. Independent scientific and patient advice is provided by Expert Review Committees (ERCs) and the Central Advisory Committee (CAC). 

A summary of all approved protocols, including a lay and technical summary of the proposed research, is published three months after researchers have access to the data to begin their study. COVID-19 research protocols are being fast-tracked and all approved summaries are published within 72 hours to ensure transparency and to help avoid unnecessary duplication. 

Protocols below are listed in order of date of approval. Please click on the study title for more details. 

Peer-reviewed publications from research using CPRD data will be listed on our bibliography page


Date of Approval Title
04/09/2018 Association of early detection of non-diabetic hyperglycaemia and clinical outcomes in England: a retrospective cohort study
10/09/2018 Characterization of acute coronary syndrome patients that switch from dual antiplatelet therapy to monotherapy with clopidogrel or aspirin
10/09/2018 Referral rates of severe asthma patients to asthma specialists in the UK and the impact on healthcare use
10/09/2018 Sodium-glucose co-transporter 2 inhibitors and the risk of fractures in patients with type 2 diabetes
10/09/2018 Mortality trends in people with and without type 2 diabetes in UK: a CPRD observational study
10/09/2018 Initiation of Combination Therapy in Type 2 Diabetes Patients with high HbA1c at diagnosis
10/09/2018 Cardiovascular risk and kidney disease progression in chronic kidney disease
11/09/2018 Uptake of pneumococcal and zoster vaccines by clinical risk groups in England
11/09/2018 Difference in Response to Inhaled Corticosteroids between smoking and non-smoking asthma patients.
19/09/2018 Impact of EU label changes for systemic diclofenac & hydroxyzine products: post-referral prescribing trends
19/09/2018 Infants’ and Children’s Primary and Secondary Health Care Costs associated with mode of Childbirth and Gestational Age at Birth
20/09/2018 The resource use, financial costs and related epidemiology of treating people with HIV and its associated comorbidities vs. matched controls in the UK general population
20/09/2018 Autoimmune blistering diseases: Incidence, prevalence, co-morbidity and prescription patterns
20/09/2018 An investigation of the adverse outcomes and resource use associated with anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) and their relationship with glucocorticoid (GC) treatment
21/09/2018 Reproducible Evidence: Practices to Enhance and Achieve Transparency (REPEAT): Study 7 - Replication of "Antibiotic treatment failure in four common infections in UK primary care 1991-2012: longitudinal analysis"
24/09/2018 Identifying patients with familial hypercholesterolemia who could benefit from treatment with proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors: Development and validation of a logistic regression predictive model
28/09/2018 Towards an accessible methodology in precision medicine: methods for time-to-event data and non-regular inferences with an application to treatment of type 2 diabetes
28/09/2018 Improved characterization of the overlap syndrome of heart failure, atrial fibrillation and acute coronary syndromes
28/09/2018 The Natural History and heterogeneity in progression of Dementia in the United Kingdom
03/10/2018 A cross sectional description of prostate cancer subgroups