Approved studies using CPRD Data

Access to CPRD data, including UK Primary Care Data, and linked data such as Hospital Episode Statistics, is subject to protocol approval via CPRD’s Research Data Governance (RDG) Process. Independent scientific and patient advice is provided by Expert Review Committees (ERCs) and the Central Advisory Committee (CAC). 

A summary of all approved protocols, including a lay and technical summary of the proposed research, is published three months after researchers have access to the data to begin their study. COVID-19 research protocols are being fast-tracked and all approved summaries are published within 72 hours to ensure transparency and to help avoid unnecessary duplication. 

Protocols below are listed in order of date of approval. Please click on the study title for more details. 

Peer-reviewed publications from research using CPRD data will be listed on our bibliography page


Date of Approval Title
22/06/2016 Immunosuppressive therapy and Parkinson's disease risk
29/06/2016 Comparative effectiveness of lansoprazole and omeprazole for the prevention of gastrointestinal bleeding and malignancy
29/06/2016 Generalizability of Clinical Trial Results: Value of Individual Data versus Aggregate Data
29/06/2016 Long-term severe non-dermatological outcomes in eczema
29/06/2016 Characterisation and cardiovascular risk profile of type 2 diabetes mellitus patients according to initiation of antidiabetic medications
29/06/2016 Pharmacoepidemiology of pancreatin use in non-cystic fibrosis patients and comparison of all-cause mortality with that of their matched controls
30/06/2016 Assessment of Metformin Use Pattern in UK using CPRD
04/07/2016 Safety study to quantify the risk of ulceration (including all sites of occurrence), and related events (including perforations, fistula, abscess and bleeding) and death among patients treated with nicorandil with and without diverticular disease
05/07/2016 Statin use and incident hand osteoarthritis: A propensity-score matched sequential cohort study
05/07/2016 Patient Characteristics Associated With Initiation Of Insulin Glargine Among Patients With Type 1 Or Type 2 Diabetes Mellitus In The United Kingdom
05/07/2016 Androgen Deprivation Therapy and Risk of Dementia
06/07/2016 Stability of blood eosinophils in COPD and controls and the impact of eosinophil count, age, gender and smoking status
06/07/2016 Sequelae of gastrointestinal infections: incidence, risk factors, and economic impact on primary and secondary care settings.
07/07/2016 Profiling the natural history of Crigler-Najjar syndrome using the Clinical Practice Research Datalink
11/07/2016 Cancer and risk of herpes zoster - case-control study in the Clinical Practice Research Datalink
11/07/2016 Age- and lifestyle-related chronic disease and causes of mortality among adults with cerebral palsy in the United Kingdom.
12/07/2016 Linaclotide Utilisation Study in the UK - Extended Feasibility Counts
19/07/2016 Unsupervised clustering and topological analysis of Type-2 Diabetes and prediabetes patients in CALIBER using clinical data from electronic medical records
20/07/2016 Risk of major bleeds associated with the use of direct oral anticoagulants in venous thromboembolism
20/07/2016 Longitudinal Analyses of Body Mass Index and Risk of Parkinson's Disease in CPRD