Approved studies using CPRD Data

Access to CPRD data, including UK Primary Care Data, and linked data such as Hospital Episode Statistics, is subject to protocol approval via CPRD’s Research Data Governance (RDG) Process. Independent scientific and patient advice is provided by Expert Review Committees (ERCs) and the Central Advisory Committee (CAC). 

A summary of all approved protocols, including a lay and technical summary of the proposed research, is published three months after researchers have access to the data to begin their study. COVID-19 research protocols are being fast-tracked and all approved summaries are published within 72 hours to ensure transparency and to help avoid unnecessary duplication. 

Protocols below are listed in order of date of approval. Please click on the study title for more details. 

Peer-reviewed publications from research using CPRD data will be listed on our bibliography page

 

Date of Approval Title
04/03/2021 Influence of allopurinol in addition to colchicine on Major Adverse Cardiac Events (MACE): a retrospective population-based cohort study
03/03/2021 Temporal trends in the incidence of common mental disorders in the United Kingdom by sociodemographic group (2000-2020)
02/03/2021 Surgical site infection in primary care following surgery for hand trauma in adults
02/03/2021 Does the association between multiple long-term conditions and mortality risk vary across sociodemographic groups?
01/03/2021 Ethnic differences in healthcare utilisation and care quality among people with multiple conditions
25/02/2021 The Comparative Safety of Acid Suppressant Drugs: Is there an Increased Risk of Colorectal Cancer?
25/02/2021 Artificial intelligence for identifying new disease clusters in patients with immune-mediated inflammatory conditions: A Proof-of-Concept Study
24/02/2021 CharacTeristics of treAtment response to hIgh dose inhaled corticosteroids(ICS)+Long acting B2 agonist(LABA) vs medium or high dOse ICS+LABA+long acting muscarinic antagonist in patients with uncontRolled moderate to severe asthma on medium dose ICS+LABA
23/02/2021 Prevalence, incidence, morbidity and mortality of early-onset type 2 diabetes.
22/02/2021 The direct and indirect effects of Covid-19 on long-term conditions: A retrospective cohort study using primary and secondary care electronic health records
18/02/2021 The effect of treatment intensification for type 2 diabetes on health outcomes in routine care and across highly granular patient subgroups: a regression discontinuity analysis
18/02/2021 Effectiveness and safety of apixaban vs rivaroxaban in patients with Atrial Fibrillation and Diabetes Mellitus
16/02/2021 Association between weight loss and fertility in women diagnosed with polycystic ovary syndrome and living with overweight or obesity
16/02/2021 Prognostic significance of initiating loop diuretics and its relationship to heart failure
16/02/2021 Association of physical conditions with challenging behaviours in people with intellectual disabilities: a longitudinal cohort study of a national sample of primary-care patients in England using the Clinical Practice Research Datalink
15/02/2021 Investigating whether in utero exposure to maternal psychotropic medication is associated with adverse pregnancy outcomes and adverse health and neurodevelopmental outcomes in offspring
15/02/2021 Sulfonylureas versus metformin as initial treatment for type 2 diabetes and the risk of ventricular arrhythmia: A population-based cohort study
11/02/2021 Moderating effects of intellectual disabilities on mortality among people with autism: a retrospective cohort study of a national sample of primary-care patients in England using the Clinical Practice Research Datalink
11/02/2021 COVID-19 recording in Clinical Practice Research Datalink primary care data and linked Second Generation Surveillance System SARS-CoV-2 virology test data
10/02/2021 Investigating whether in utero exposure to maternal antihypertensive medication is associated with adverse pregnancy outcomes and adverse health and neurodevelopmental outcomes in offspring