Approved studies using CPRD Data

Applications to access CPRD data for observational research are reviewed by the Independent Scientific Advisory Committee (ISAC). Approval by ISAC is required for researchers to carry out their proposed studies.

A summary of all ISAC-approved protocols, including a lay and technical summary of the proposed research, is published three months after researchers have access to the data to begin their study. COVID-19 research protocols are being fast-tracked and all approved summaries are published within 72 hours to ensure transparency and to help avoid unnecessary duplication.

The table below includes all ISAC-approved protocols submitted to CPRD from 1st July 2015. Protocols below are listed in order of date of approval. Please click on the study title for more details.

Peer-reviewed publications from research using CPRD data will be listed on our bibliography page


Date of ISAC Approval Title
31/07/2020 Indirect acute effects of the COVID-19 pandemic on physical and psychological morbidity in the UK
30/07/2020 Using Real-World Data to Examine the Impact of Different Target Populations on the Representativeness of Cardiovascular Outcome Trials of Antidiabetic Drugs
30/07/2020 An investigation of excess mortality and end-of-life morbidity patterns before and during the COVID-19 pandemic. A retrospective analysis using primary care data
30/07/2020 Using linked primary care and viral surveillance data to develop risk stratification models to inform management of severe COVID-19
29/07/2020 Real-world utilization of and comparative outcomes arising from novel oral anticoagulants for atrial fibrillation and stroke prevention in the United Kingdom
23/07/2020 Exploring patterns of healthcare resource utilisation and COPD exacerbations in patients with chronic obstructive pulmonary disease for health technology assessment
20/07/2020 Determining the applicability and feasibility of using regression discontinuity in electronic health record data
14/07/2020 A descriptive analysis of Pompe disease and Fabry disease based on UK electronic primary healthcare records and linked secondary care data
13/07/2020 Antibiotic prescribing and risk of herpes zoster: a case-control study
13/07/2020 Hormone replacement therapy and dementia risk: nested case-control studies using CPRD and QResearch
08/07/2020 Retrospective cohort study on first-time use of insulin detemir for diabetes type 2 glycaemic control in elderly and multimorbidity patients living in the United Kingdom
08/07/2020 The Incidence of Cancer Overall and Site-Specific Cancer Among Patients with Type 2 Diabetes Between 1988 and 2019
08/07/2020 Descriptive analysis of patterns of primary care demand in England during the COVID-19 pandemic
07/07/2020 Primary care service use towards end of life among patients who died before and during the COVID-19 epidemic: a nationwide cohort study using the Clinical Practice Research DataLink
01/07/2020 Evaluation of the drivers in heterogeneity in unplanned hospital admissions and mortality in frail and multimorbidity elderly patients before and during/after COVID-19
29/06/2020 Selective Serotonin Reuptake Inhibitors and the Risk of Type 2 Diabetes Mellitus in Children and Youths
23/06/2020 Examining methodology to identify patterns of consulting in primary care for different groups of patients before a diagnosis of cancer: a matched retrospective cohort study
23/06/2020 The prevalent new-user design for cohort studies with no active comparator: The example of statins and cancer
18/06/2020 Risk factors and outcomes of COVID-19 in individuals with Down syndrome
17/06/2020 Area, maternal and child determinants of MMR uptake