Approved studies using CPRD Data

Access to CPRD data, including UK Primary Care Data, and linked data such as Hospital Episode Statistics, is subject to protocol approval via CPRD’s Research Data Governance (RDG) Process. Independent scientific and patient advice is provided by Expert Review Committees (ERCs) and the Central Advisory Committee (CAC). 

A summary of all approved protocols, including a lay and technical summary of the proposed research, is published three months after researchers have access to the data to begin their study. COVID-19 research protocols are being fast-tracked and all approved summaries are published within 72 hours to ensure transparency and to help avoid unnecessary duplication. 

Protocols below are listed in order of date of approval. Please click on the study title for more details. 

Peer-reviewed publications from research using CPRD data will be listed on our bibliography page


Date of Approval Title
03/11/2020 To investigate the prevalence, incidence and mortality for Interstitial Lung Disease (ILD) in the UK for the study period 2009 to 2019
02/11/2020 Cardiometabolic disease prediction using general practice consultation pattern: Use of Machine Learning (ML)
02/11/2020 A population-based longitudinal study in England of suicide risk indicators: behavioural, clinical and biosocial
30/10/2020 Exploring clinical pathways of knee joint replacement using large-scale electronic healthcare record data
28/10/2020 Proposal to develop an algorithm to link mothers to their children in CPRD Aurum
28/10/2020 Comparative adherence and persistence of single & multiple inhaler triple therapies among patients with Chronic Obstructive Pulmonary Disease in the United Kingdom in a real-world primary care setting
28/10/2020 Characteristics and treatment pathways among patients with chronic obstructive pulmonary disease receiving single device dual inhaler therapy in the UK in a real-world setting
26/10/2020 European non-interventional post-authorization safety study related adherence to the risk minimization measures for romosozumab by the EU-ADR Alliance
26/10/2020 Application of machine learning algorithms on electronic health records to examine patterns of disease clustering and trajectories
23/10/2020 Chronic kidney disease burden and characterisation of patients by renal function testing, treatments and comorbidities - an observational study
21/10/2020 An investigation of the reliability and granularity of the recording of interstitial lung diseases in primary and secondary care datasets
20/10/2020 MuSculoskeletal paiN durIng the COVID-19 PandEmic: an observational study of UK national primary care electronic health records (the SNIPE Study)
20/10/2020 Development of a prediction model in Pompe disease, Fabry disease, and Gaucher disease based on UK electronic primary healthcare records and linked secondary care data.
19/10/2020 Near real time vaccine safety monitoring for COVID-19 vaccines
15/10/2020 The impact of painful musculoskeletal conditions on outcomes of cardiovascular disease
15/10/2020 Second-line combined treatment with metformin and DPP-4 inhibitors in type 2 diabetes and risk of major cardiovascular events, cardiovascular and all-cause mortality: a prevalent new-user cohort study
14/10/2020 The prescribing trends and health risks of prescribed analgesic medication in the UK: an observational study based on the UK Clinical Practice Research Datalink
14/10/2020 Burden and consequences of the use of COPD-related systemic corticosteroids
14/10/2020 Which patient groups benefit from statins? A regression discontinuity study
12/10/2020 Characterisation of nasal polyp patients with and without surgery in England (CPRD-HES)