Approved studies using CPRD Data

Access to CPRD data, including UK Primary Care Data, and linked data such as Hospital Episode Statistics, is subject to protocol approval via CPRD’s Research Data Governance (RDG) Process. Independent scientific and patient advice is provided by Expert Review Committees (ERCs) and the Central Advisory Committee (CAC). 

A summary of all approved protocols, including a lay and technical summary of the proposed research, is published three months after researchers have access to the data to begin their study. COVID-19 research protocols are being fast-tracked and all approved summaries are published within 72 hours to ensure transparency and to help avoid unnecessary duplication. 

Protocols below are listed in order of date of approval. Please click on the study title for more details. 

Peer-reviewed publications from research using CPRD data will be listed on our bibliography page


Date of Approval Title
12/10/2020 An observational cohort study of intermittent oral corticosteroid use and its association with adverse outcomes and healthcare resource use and costs in asthma using the Optimum Patient Care Research and Clinical Practice Research Datalink databases.
08/10/2020 Real world disease burden and treatment patterns among patients diagnosed with gastroparesis in England
08/10/2020 Descriptive efficiency and safety of a combination of ramipril and bisoprolol in patients with primary hypertension: A Database Study
07/10/2020 Prevalence and socio-economic distribution of patients with atherosclerotic cardiovascular disease (ASCVD) and hypercholesterolemia, ASCVD-risk equivalent patients with hypercholesterolemia, and familial hypercholesterolemia
06/10/2020 Which patient groups at risk for type 2 diabetes benefit from lifestyle interventions: a regression discontinuity design
06/10/2020 Pharmacological risk factors for community-acquired pneumonia in asthma: population-based study in England
06/10/2020 Atrial Fibrillation, cognitive impairment, dementia, and the impact of antithrombotic therapy: A population-based cohort study using the Clinical Practice Research Datalink.
05/10/2020 Metformin, lifestyle advice, and risk of Type 2 Diabetes Mellitus. A comparative effectiveness cohort study in older prediabetic patients, in the Clinical Practice Research Practice AURUM
02/10/2020 Outcome of fractures in people with intellectual disabilities
30/09/2020 Quality and completeness of breast cancer recording in CPRD Aurum compared to CPRD GOLD
30/09/2020 Musculoskeletal adverse outcomes after treatment with aromatase inhibitors for breast cancer
28/09/2020 Metformin and the risk of multiple sclerosis: A population based cohort study
25/09/2020 Non-steroidal anti-inflammatory drugs and the risk of myocardial infarction: a nested case-control study in the UK Clinical Practice Research Datalink GOLD
25/09/2020 Safety of non-steroidal anti-inflammatory drug (NSAID) prophylaxis when initiating urate-lowering therapy for gout: an observational study in UK primary care using the Clinical Practice Research Datalink
25/09/2020 Global burden of hip fractures – trends in incidence, post-fracture treatment, and mortality; a multi-country, observational study
25/09/2020 Epidemiological investigations of the role of viral infections, viral treatments, vaccination prevention and the risk of dementia
25/09/2020 Epidemiology of anticoagulants prescribing in non-valvular atrial fibrillation patients in England: a cohort study exploring disease incidence and anticoagulants prescribing trends, comparing clinical outcomes, and risk of recurrent bleeding events
24/09/2020 Mode of delivery for childbirth in the UK Clinical Practice Research Datalink (CPRD) and Hospital Episodes Statistics (HES), 1998-2020: investigating the usability, completeness and temporal trends in mode of delivery data
22/09/2020 Using large-scale routine data to monitor and improve ethnic inequalities in cancer and cardiovascular disease
22/09/2020 Estimating the effects of early intervention services for first-episode psychosis and model fidelity on hospitalisations: a quasi-experimental study