Approved studies using CPRD Data

Access to CPRD data, including UK Primary Care Data, and linked data such as Hospital Episode Statistics, is subject to protocol approval via CPRD’s Research Data Governance (RDG) Process. Independent scientific and patient advice is provided by Expert Review Committees (ERCs) and the Central Advisory Committee (CAC). 

A summary of all approved protocols, including a lay and technical summary of the proposed research, is published three months after researchers have access to the data to begin their study. COVID-19 research protocols are being fast-tracked and all approved summaries are published within 72 hours to ensure transparency and to help avoid unnecessary duplication. 

Protocols below are listed in order of date of approval. Please click on the study title for more details. 

Peer-reviewed publications from research using CPRD data will be listed on our bibliography page


Date of Approval Title
21/09/2020 Incidence, prevalence, resource use and clinical outcomes of heart failure in England: a linked descriptive analysis of primary and secondary care (PULSE)
18/09/2020 Quality and completeness of rheumatoid arthritis (RA) diagnosis in CPRD GOLD and CPRD AURUM
18/09/2020 Which patient groups benefit from thyroid hormone replacement therapy: a regression discontinuity design
17/09/2020 A comparison of cancer incidence and prevalence in CPRD GOLD and CPRD Aurum primary care databases
17/09/2020 Understanding the prevalence and characteristics of frequent attenders in general practice using the Clinical Practice Research Datalink
16/09/2020 Drug-drug interactions and the risk of sulfonylurea-induced hypoglycaemia
16/09/2020 Examining primary care interactions, monitoring, prescribing and outcomes pre, during, and post Covid-19 in people with diabetes
16/09/2020 Association Between Opioid Prescriptions and Postoperative Anastomotic Leak After Restorative Proctectomy for Rectal Cancer
14/09/2020 Anxiety and depression amongst secondary school children: variation across academic years and the relationship with high-stakes examinations
10/09/2020 Incretin-based drugs and the risk of intestinal obstruction among patients with type 2 diabetes
09/09/2020 The impact of the quality and accessibility of primary health care on avoidable mortality: a longitudinal comparison of people with intellectual disabilities and the general population
08/09/2020 ALETHEIA: An observational study on treatment patterns and clinical outcomes of patients experiencing a myocardial infarction in clinical practice
08/09/2020 Assessment of Prevalence and Risk Factors for Psychiatric Morbidity after Restorative Proctectomy for Rectal Cancer – A Population-Based Cohort Study
08/09/2020 Fertility rates and pregnancy outcomes in women with psoriasis and psoriatic arthritis: a population-based cohort study
07/09/2020 The care home residency population in the United Kingdom: osteoporosis-related characteristics, outcomes, and patterns of care – a descriptive study
04/09/2020 Mapping the prevalence of Chronic Venous Disease in England
01/09/2020 Long-acting insulin analogues and the risk of diabetic retinopathy in type 2 diabetes patients
01/09/2020 Comparing the Estimated Risk of Hip Fracture Among Subjects Exposed to Tramadol as Compared to Subjects Exposed to Codeine
28/08/2020 Improving the definition of recurrent UTI and understanding patient factors associated with greater frequency of recurrence
28/08/2020 Development and validation of a risk stratification tool for patients with acute myocardial infarction (AMI) in UK primary care